Effect of exercise on plasma atrial natriuretic factor and cardiac function in men and women

Abstract

Abstract. In order to provide an integrated view of the physiology of atrial natriuretic factor (ANF) during exercise, we studied changes of its plasma concentrations in 13 normal subjects (seven males, six females) during three graded exercise levels and two periods of recovery (5 and 30 min), concomitantly with an assessment of cardiac function and ventricular volumes by multigated radionuclide angiography.Mean ANF levels (k SEM) increased in all patients at the second (P < 0.002) and third (P < 0.002) exercise levels, and after 5-min recovery (P<O.Ol): in males from 1 6 f 7 to 30+ 1 I pg ml-' at the third level, in females from 27f12 to 61 f 3 3 pg ml-I. Normal values were observed after 30-min recovery. Even if mean ANF levels were all higher in females, this difference did not reach statistical significance (P = 0.06). Significant decreases of ventricular volumes, as well as increases of ejection fraction and rate pressure product, were noted during exercise and were similar in both sexes. The kinetics of plasma ANF concentrations, compared with the increase of rate pressure product, was characterized by a latency and a remanence in recovery. This remanence, also present in the changes of ventricular volumes, supports the hypothesis that other factor(s) like catecholamines might still exert their influence after the exercise stops.

Hormonal responses to the 6-minute walk test in women and men with coronary heart disease: A pilot study

“…35 In healthy adults, 4 to 10 minutes of upright exercise that ranges from 20% to 100% of exercise capacity also stimulated HR and systolic BP but not diastolic BP. 20,21,[24][25][26] In summary, our results show that basal plasma VP concentration was significantly higher in men than in women who have CHD but not LVD and symptomatic CHF. Moreover, we determined that the 6-minute walk test is an exercise of sufficient intensity and duration to elicit a significant change in VP, ANP, NE, EPI, HR, and systolic BP in those with CHD.…”

“…Interestingly, it has been shown in healthy adults that brief (4-to 10-minute) periods of upright exercise at moderate to heavy workloads (60% to 80% of maximal exercise capacity) resulted in significant increases in plasma concentrations of VP (P Ͻ .05), ANP (P Յ .05), NE (P Յ .05), EPI (P Յ .05), and in PRA (P Ͻ .01). [20][21][22][23][24][25][26] It is possible that the 6-minute walk test was not an adequate challenge to stimulate the release of renin. It also is possible that the presence of CHD blunted the response of PRA to the 6-minute walk test.…”

“…It has been shown in healthy young adults that plasma ANP increased in both women and men, but there was no gender difference at rest or in response to exercise performed on a bicycle ergometer in a semisupine position. 26 Relative to PRA, we are again cautious regarding interpretation of the data because 7 women, but only 1 man, were on a ␤-blocker medication, and 2 women but only 3 men were on an ACE inhibitor. Plasma concentrations for ALDO and CORT were not measured after exercise.…”

“…[20][21][22][23][24][25][26] However, the presence of chronic CHD and CHF alters the exercise-induced changes in these hormonal responses. [27][28][29][30][31] Such changes in these hormones may serve as indicators of the severity of cardiac disease.…”

Heart Failure Induced by Pheochromocytoma: Laparoscopic Treatment and Intraoperative Changes of Several New Cardiovascular Hormones

“…1). The methods for ANF, ANG II and ET-1 measurements using sensitive and specific radioimmunoassays after plasma extraction have been previously described in great detail by our group [4, 5]. N-terminal proANF was measured using specific antibodies and synthetic peptides from Peninsula (Belmont, Calif., USA) after plasma extraction on Sep-Pak C18 cartridges.…”