Effect of Exercise on the Cognitive Function of Older Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Cai, Yihui; Wang, Zi; Feng, Leyi; Ni, Guo-Xin

doi:10.3389/fnhum.2022.876935

Cited by 26 publications

(9 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Memory performance was associated with body composition changes in previous studies in T2D [ 45 ]. Strategies to improve both cardiorespiratory fitness and cognition have been proposed, such as exercise training [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Acute Effects of a Maximal Cardiopulmonary Exercise Test on Cardiac Hemodynamic and Cerebrovascular Response and Their Relationship with Cognitive Performance in Individuals with Type 2 Diabetes

Besnier

Gagnon

Monnet

et al. 2023

IJERPH

View full text Add to dashboard Cite

Cardiovascular and cerebrovascular diseases are prevalent in individuals with type 2 diabetes (T2D). Among people with T2D aged over 70 years, up to 45% might have cognitive dysfunction. Cardiorespiratory fitness (V˙O2max) correlates with cognitive performances in healthy younger and older adults, and individuals with cardiovascular diseases (CVD). The relationship between cognitive performances, V˙O2max, cardiac output and cerebral oxygenation/perfusion responses during exercise has not been studied in patients with T2D. Studying cardiac hemodynamics and cerebrovascular responses during a maximal cardiopulmonary exercise test (CPET) and during the recovery phase, as well as studying their relationship with cognitive performances could be useful to detect patients at greater risk of future cognitive impairment. Purposes: (1) to compare cerebral oxygenation/perfusion during a CPET and during its post-exercise period (recovery); (2) to compare cognitive performances in patients with T2D to those in healthy controls; and (3) to examine if V˙O2max, maximal cardiac output and cerebral oxygenation/perfusion are associated with cognitive function in individuals with T2D and healthy controls. Nineteen patients with T2D (61.9 ± 7 years old) and 22 healthy controls (HC) (61.8 ± 10 years old) were evaluated on the following: a CPET test with impedance cardiography and cerebral oxygenation/perfusion using a near-infrared spectroscopy. Prior to the CPET, the cognitive performance assessment was performed, targeting: short-term and working memory, processing speed, executive functions, and long-term verbal memory. Patients with T2D had lower V˙O2max values compared to HC (34.5 ± 5.6 vs. 46.4 ± 7.6 mL/kg fat free mass/min; p < 0.001). Compared to HC, patients with T2D showed lower maximal cardiac index (6.27 ± 2.09 vs. 8.70 ± 1.09 L/min/m2, p < 0.05) and higher values of systemic vascular resistance index (826.21 ± 308.21 vs. 583.35 ± 90.36 Dyn·s/cm5·m2) and systolic blood pressure at maximal exercise (204.94 ± 26.21 vs. 183.61 ± 19.09 mmHg, p = 0.005). Cerebral HHb during the 1st and 2nd min of recovery was significantly higher in HC compared to T2D (p < 0.05). Executive functions performance (Z score) was significantly lower in patients with T2D compared to HC (−0.18 ± 0.7 vs. −0.40 ± 0.60, p = 0.016). Processing speed, working and verbal memory performances were similar in both groups. Brain tHb during exercise and recovery (−0.50, −0.68, p < 0.05), and O2Hb during recovery (−0.68, p < 0.05) only negatively correlated with executive functions performance in patients with T2D (lower tHb values associated with longer response times, indicating a lower performance). In addition to reduced V˙O2max, cardiac index and elevated vascular resistance, patients with T2D showed reduced cerebral hemoglobin (O2Hb and HHb) during early recovery (0–2 min) after the CPET, and lower performances in executive functions compared to healthy controls. Cerebrovascular responses to the CPET and during the recovery phase could be a biological marker of cognitive impairment in T2D.

show abstract

Section: Discussionmentioning

confidence: 99%

Acute Effects of a Maximal Cardiopulmonary Exercise Test on Cardiac Hemodynamic and Cerebrovascular Response and Their Relationship with Cognitive Performance in Individuals with Type 2 Diabetes

Besnier

Gagnon

Monnet

et al. 2023

IJERPH

View full text Add to dashboard Cite

show abstract

“…Both longer and short sleep duration were associated with higher risks of cognitive impairment (27). Doing exercise have positive effect on improving cognitive function (8,28). An umbrella review evaluated 28,205 participants with mild cognitive impairment or dementia, physical activity was not only effective in improving global cognition in Alzheimer disease and in all types of dementia, but also improved noncognitive outcomes in people with dementia including falls, and neuropsychiatric symptoms (8).…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies indicated that physical activity is beneficial in improving global cognitive function (8,28). An Updated Umbrella Review of the 2018 Physical Activity Guidelines Advisory Committee Report suggested that physical activity improved sleep in adults with insomnia symptoms or obstructive sleep apnea (29).…”

Section: Discussionmentioning

confidence: 99%

Joint association of sleep duration and physical activity with cognitive performance among Chinese adults: an analysis of nationally representative survey data

Tao,

Wang,

Jia

2023

Front. Public Health

View full text Add to dashboard Cite

BackgroundAlthough previous studies have identified that both physical activity and sleep problems are independently associated with decreased risk of cognitive function. However, the joint association of physical activity and sleep duration with cognitive function was rarely studied.MethodsA total of 21,128 participants who had records from the China Family Panel Studies (CFPS) in 2018 were included in this study. Linear regression was used to examine the associations of joint between physical activity and sleep duration with cognitive function in the nationally representative survey data.ResultsCompared with individuals reporting 150 min/week or more of activity, those reporting no physical activity had a 116% higher risk of getting lower vocabulary scores (coefficient: -1.16, 95% CI: −1.55 ~ −0.78) and a 61% higher risk of getting lower mathematics scores (coefficient: -0.61, 95% CI: −0.78 ~ −0.44). Compared with those who slept for 7–10 h/day, those who slept more than 10 h/day had the lower vocabulary scores (coefficient: −1.34, 95% CI: −1.86 ~ −0.83) and mathematics scores (coefficient: −0.68, −0.94 ~ −0.42). The results of joint analysis showed that the adjusted coefficient for vocabulary scores were − 2.58 (95% CI, −3.33 ~ −1.82) for individuals reporting no physical activity and sleeping for 10 h/day, and − 1.00 (95% CI, −1.88 ~ −0.12) for individuals reporting more than 150 min/week and sleeping for 10 h/day, compared with those who reported a sleep duration for 7–10 h/day and more than 150 min/week physical activity, Any level of physical activity combined with longer sleep duration (≥10 h/day) was associated with a higher risk of getting low mathematics scores.ConclusionAppropriate sleep and sufficient physical activity together may have amplified association on cognitive performance, highlighting the importance of a comprehensive healthy lifestyle.

show abstract

“…Similarly, meta-analyses have found that exercise significantly improves global cognitive function in elderly patients with T2D. 13 But the evidence in cognitive subdomains is limited and inconsistent. 14 15 PA levels differ between male and female with T2D.…”

Section: Introductionmentioning

confidence: 99%

Gender differences in the association between physical activity and cognitive subdomains among elders with type 2 diabetes and mild cognitive impairment: a cross-sectional study

Xie,

You,

Zheng

et al. 2024

BMJ Open

View full text Add to dashboard Cite

ObjectivesThe objective of this study was to evaluate the gender differences in the correlation between physical activity (PA) and cognitive subdomains in elderly individuals with type 2 diabetes (T2D) and mild cognitive impairment (MCI).DesignCross-sectional study.SettingThe research was carried out in communities located in Fuzhou, Fujian Province and Beijing Municipality.ParticipantsCommunity-dwelling elders with T2D and MCI aged 60 years or older were eligible for this study.Primary outcome measures and analysesThe weekly PA score was assessed using the International Physical Activity Questionnaire (IPAQ). The cognitive subdomains were evaluated through a battery of cognitive assessments, including the Rey Auditory Verbal Learning Test (RAVLT), Trail Making Test Part B, Digit Symbol Substitution Test (DSST) and the Stroop Color-Word Test (SCWT). Multiple linear regression models were employed to examine the association between PA and cognitive subdomains in both male and female individuals.ResultsIn older men, higher total IPAQ score was positively correlated with higher RAVLT (P=0.011) and SCWT (P=0.049). There was a significant interaction between the total PA score and gender in relation to RAVLT (P=0.008) and SCWT (P=0.027). Moreover, there was a positive correlation between moderate-vigorous PA level and RAVLT in older men (P=0.007). Additionally, a positive correlation was found between moderate-vigorous PA level and DSST in older women (P=0.038).ConclusionIn older individuals with T2D and MCI, the association between PA and cognitive subdomains differs between men and women. This discrepancy may impact the customisation of exercise recommendations.

show abstract

Effect of Exercise on the Cognitive Function of Older Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Cited by 26 publications

References 66 publications

Acute Effects of a Maximal Cardiopulmonary Exercise Test on Cardiac Hemodynamic and Cerebrovascular Response and Their Relationship with Cognitive Performance in Individuals with Type 2 Diabetes

Acute Effects of a Maximal Cardiopulmonary Exercise Test on Cardiac Hemodynamic and Cerebrovascular Response and Their Relationship with Cognitive Performance in Individuals with Type 2 Diabetes

Joint association of sleep duration and physical activity with cognitive performance among Chinese adults: an analysis of nationally representative survey data

Gender differences in the association between physical activity and cognitive subdomains among elders with type 2 diabetes and mild cognitive impairment: a cross-sectional study

Contact Info

Product

Resources

About