Effect of exercise, synthetic anabolic steroids and protein intake on DNA damage in trained and untrained men

Shafi, Farha A. Ali; Jabbar, Enas Abdul Kareem; Yousif, Rawia M.; Lafta, Fadhel M.

doi:10.1016/j.mgene.2020.100685

Cited by 6 publications

(3 citation statements)

References 28 publications

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“…Our results showed that the individuals in the present study had an average of 1.61 micronuclei cells per 1,000 cells analyzed. Similar data to the present was reported by Shafi et al (2020), who found a frequency of 1.6 and 2.0 micronuclei per 2,000 cells analyzed from bodybuilders supplement users and non-supplement users, respectively.…”

Section: Brazil and Spain Were Verified By Thesupporting

confidence: 92%

“…Other studies have reported no effect of exercise on micronucleus frequency, after an exhaustive session on the cycle ergometer or after a short-distance triathlon (PITTALUGA et al, 2006;HARTMANN et al, 1998). As in the study of Shafi et al (2020), no differences were observed in the micronuclei frequency of oral cells among bodybuilders, soccer players, and sedentary individuals.…”

Section: Theoretical Fundamentalsmentioning

confidence: 55%

“…Furthermore, among exercisers, some evidence suggests that there are no differences in the frequency of DNA damage among resistance exercisers, aerobic exercisers, and sedentary individuals (REICHHOLD et al, 2009;SHAFI et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

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Dna Damage and Other Nuclear Anomalies Among Gym Users: A Comparative Study Between Brazil and Spain

Colombelli

Uebel²,

Schlickmann³

et al. 2022

RJP

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Populations from different countries may present different cellular modifications among themselves, and the Buccal Micronucleus Cytome (BMCyt) assay in human buccal mucosal tissue may be a marker to evaluate these modifications. This study evaluated and compared DNA damage and other nuclear anomalies between Brazilian and Spanish gym users. This is a cross-sectional study carried out with gym users of Santa Cruz do Sul/Brazil and Madrid/Spain. The BMCyt assay was performed for biomarkers of DNA damage (micronuclei and/or nuclear buds), cytokinetic defects (binucleated cells), proliferative potential (basal cell frequency) and/or cell death (condensed chromatin, karyorrhexis, pyknotic and karyolytic cells) in human buccal mucosal. Of the 228 individuals evaluated, 163 were Brazilian, and 65 were Spanish. Gym users of both countries differed between weight, body mass index, body fat, and muscle mass. The Brazilians presented a significantly higher frequency of micronuclei, nuclear buds, cells with condensed chromatin and karyorrhexis. Spaniards, however presented a significantly higher frequency of karyolytic cells. In conclusion, Brazilian gym users presented significantly higher rates of DNA damage and cell death, while the Spanish presented a higher frequency of advanced stage cell death.

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Section: Brazil and Spain Were Verified By Thesupporting

confidence: 92%