Effect of exercise training and diet modification on serum lipids and lipoproteins in coronary artery disease patients treated with thiazides

Abstract

Summary:The effects of chronic exercise training and diet modification on serum lipids and lipoproteins were measured in 17 hypertensive males and 41 normotensive males with documented coronary artery disease (CAD). Exercise consisted of aerobic activities which were performed at approximately 75-85 % of the symptom-limited maximum heart rate for 30-40 minutes, three times weekly for 3 months. Each participant's diet was also controlled, the recommended daily intake of fat and cholesterol was no more than 40 g/day and 200 mg/day, respectively. Significant increases in estimated \j@-and total cholesterol/high density lipoprotein (HDL) and a significant decrease in serum triglycerides were documented after training. Significant differences in serum cholesterol and triglycerides between the nondiuretic and diuretic patients were also noted. No significant changes were found in low density lipoprotein (LDL), HDL, or body weight. Vigorous aerobic training and diet modification can favorably modify the deleterious effects of diuretic medications on serum triglycerides and total cholesterol/HDL in patients with documented CAD.

A Randomized Controlled Trial of the Effects of Aerobic Dance Training on Blood Lipids Among Individuals with Hypertension on a Thiazide

“…Furthermore, studies of higher frequency of exercise per week or longer duration of exercise training, demonstrated differential findings [30,31]. Indeed, Kahrs et al [23] opined that higher exercise intensities and longer intervention periods may be necessary to elicit the desired changes in serum lipid levels.…”

“…Kahrs et al [23] reported a decrease in triglyceride after a 12-week vigorous intensity aerobic exercise and diet modification in individuals with coronary heart disease on thiazides. However, Kahrs et al [23] did not find a significant reduction in LDL-C.…”

“…Kahrs et al [23] reported a decrease in triglyceride after a 12-week vigorous intensity aerobic exercise and diet modification in individuals with coronary heart disease on thiazides. However, Kahrs et al [23] did not find a significant reduction in LDL-C. The difference in findings between Kahrs et al's findings and those from the current study can be attributed to the differential exercise training intensity and involvement of diet modification in the previous study.…”

“…However, only a few studies on the effects of aerobic exercise on serum lipid levels reported the use of antihypertensive drugs by the participants [14,22]. Although, Kahrs et al [23] had investigated the effect of high-intensity aerobic exercise and diet modification on serum lipid levels and lipoprotein in coronary artery disease patients treated with thiazides, a similar study among individuals with hypertension seems not to be available. Thus it is currently unknown whether aerobic exercise will improve the adverse effect of thiazide diuretics on lipoprotein metabolism.…”

Physical Exercise and Antihypertensive Drugs

“…Training may be beneficial in counteracting the increase of serum lipids frequently induced by diuretics as shown by Kahrs et al [1985],…”