Effect of Exercise Training on Glomerular Filtration Rate of Mice with Various Degrees of Renal Mass Reduction

Averbukh, Zhan; Marcus, E. L.; Berman, Sylvia; Shiloah, Eliahou; Horn, Tipha; Weissgarten, Joshua; Golik, Ahuva; Cohn, M.; Rosenmann, E.; Modai, David

doi:10.1159/000168441

Cited by 8 publications

(4 citation statements)

References 12 publications

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“…Increased physical activity exerts a protective effect against CKD by reducing cardiometabolic risk factors [9,28]. In fact, an experimental study found that repeated exercise increased GFR along with a reduction in renal mass in mice [35]. …”

Section: Discussionmentioning

confidence: 99%

Sleep duration and chronic kidney disease: The Korean Genome and Epidemiology Study (KoGES)-Kangwha study

Choi

Kim

Lee

et al. 2017

Korean J Intern Med

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Background/AimsSleep duration affects health in various ways. The objective of this study was to investigate the associations of sleep duration with chronic kidney disease (CKD) in a Korean adult population.MethodsThis cross-sectional analysis was conducted for total of 1,360 participants who completed baseline health examinations for the Korean Genome and Epidemiology Study-Kangwha study in 2010 to 2011. Sleep habits were measured by an interviewer-assisted questionnaire. Sleep duration was calculated based on the number of hours per day participants had slept over the past 1 year. CKD was defined as either proteinuria or estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2. Multiple logistic regression models were applied to examine associations between sleep duration and CKD.ResultsWomen with very long sleep duration (≥ 9 hours/day) were at significantly increased odds for having high serum creatinine (odds ratio [OR], 2.936; 95% confidence interval [CI], 1.176 to 7.326), low eGFR (OR, 3.320; 95% CI, 1.372 to 8.034), and CKD (OR, 3.112; 95% CI, 1.315 to 7.363), compared those with a typical sleep duration (7 to < 8 hours/day), after adjusting for sociodemographic status, socioeconomic status, health behaviors, comorbidities, and sleep quality. Among women, for every 1 hour increase in sleep duration per day, there was a 24.6% increase in the presence of CKD (OR, 1.246; 95% CI, 1.019 to 1.523). However, among men, sleep duration was not significantly associated with CKD.ConclusionsVery long sleep duration was independently associated with a higher prevalence of CKD among Korean women. Gender may influence this association.

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Section: Discussionmentioning

confidence: 99%

Sleep duration and chronic kidney disease: The Korean Genome and Epidemiology Study (KoGES)-Kangwha study

Choi

Kim

Lee

et al. 2017

Korean J Intern Med

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“…Interestingly, studies with uremic animals (Heifets et al, 1987;Osato et al, 1990) have shown that swimming exercise significantly reduces proteinuria and the degree of glomerulosclerosis in rats compared with sedentary animals but land-based exercise does not improve renal function in small animals (Averbukh et al, 1992;Bergamaschi et al, 1997). We have reported previously in an experimental study (Pechter et al, 2009) that regular long-time swimming without exhaustion shows renoprotective properties in rats with experimental CKD: the degree of glomerulosclerosis and interstitial fibrosis was significantly less prominent and the expression of mRNA for chemokine MCP-1 in glomeruli of CKD rats that swam regularly was significantly lower.…”

Section: Discussionmentioning

confidence: 99%

Regular aquatic exercise for chronic kidney disease patients

Pechter

Raag²,

Ots-Rosenberg³

2014

International Journal of Rehabilitation Research

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Chronic kidney disease (CKD) patients not yet in dialysis can benefit from increased physical activity; however, the safety and outcomes of aquatic exercise have not been investigated in observational studies. The aim of this study was to analyze association of 10 years of regularly performed aquatic exercise with the study endpoint--that is, all-cause death or start of dialysis. Consecutive CKD patients were included in the study in January 2002. The exercise group (n=7) exercised regularly under the supervision of physiotherapist for 10 years; the control group (n=9), matched in terms of age and clinical parameters, remained sedentary. Low-intensity aerobic aquatic exercise was performed regularly twice a week; 32 weeks or more of exercise therapy sessions were conducted annually. None of the members of the aquatic exercise group reached dialysis or died in 10 years. In the sedentary control group, 55% reached the study endpoint--renal replacement therapy (n=2) or all-cause death (n=3). Occurrence of the study endpoint, compared using the exact multinomial test with unconditional margins, was statistically significantly different (P-value: 0.037) between the study groups. Regular supervised aquatic exercise arrested CKD progression. There was a statistically significant difference between the sedentary group and the exercise group in reaching renal replacement therapy or all-cause death in a follow-up time of 10 years.

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“…We regret that Eidemak et al [1] failed to mention and discuss our investigation [2] which we feel is relevant to the subject they studied. We have demonstrated that repeated physical exertion under optimal environmental conditions produced a rise in GFR in sham-operated and uninephrectomized mice.…”

Section: Introductionmentioning

confidence: 93%