Effect of Exhausting Exercise on Oxidative Stress in Health, Hemodialysis and Professional Sport

Abstract

The aim of presented study is to compare parameters of oxidative stress in untrained volunteers, patients with chronic, non-motor related disease (dialysis patients) and professional athletes before and after exhaustive exercise. 40 subjects participated in the study: 14 healthy, untrained subjects, 12 hemodialysis patients and 14 professional rowers. Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and non-transferrin bound iron (NTBI) were determined before and after exercise. Dialysis patients have increased oxidative stress at rest with highest NTBI, and show adaptation with increased values of GPx and decreased SOD. Professional athletes have low level of oxidative stress at basic circumstances with lowest NTBI, SOD, CAT and GPx as compared to untrained volunteers and dialysis patients. After strenuous exercise elevation of antioxidative enzymes is observed only in athletes, but not in untrained and dialysis patients. Due to limited antioxidative capacity, extreme physical effort is probably not recommended to dialysis patients and untrained people.

The Potential Modulatory Effects of Exercise on Skeletal Muscle Redox Status in Chronic Kidney Disease

“…The same was observed after 12 weeks of aquatic exercise [ 211 ]. Interestingly, a study compared OS parameters in untrained volunteers, CKD patients and professional athletes before and after a strenuous exercise in a rowing cycle ergometer and showed that only athletes presented elevation of antioxidant enzymes due to limited antioxidant capacity in both untrained and dialysis patients, yet the last exhibited increased OS [ 212 ]. Moreover, resistance exercises during dialysis appear to be capable of inducing Nrf2 activation [ 213 ] ( Figure 4 ).…”

The Impact of Competitive Sports on Oral Health: Exploring Their Relationship with Salivary Oxidative Stress in Children

“…This suggests that the training experience can influence oxidative stress levels in athletes, regardless of gender. Regular physical training seems to reduce the oxidative stress associated with exercise, as trained athletes show less evidence of oxidative stress for a given bout of exercise [5]. This suggests that regular training can enhance the defense system of athletes against oxidative stress.…”