Effect of experimental parameters on the formation of chitosan–poly(acrylic acid) nanofibrous scaffolds and evaluation of their potential application as DNA carrier

Wang, Jianwen; Chen, Ching-Yi; Kuo, Yi‐Ming

doi:10.1002/app.31287

Cited by 7 publications

(5 citation statements)

References 42 publications

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“…These parameters vary according tothe preparation conditions (volume ratio of CS to PAA, final suspension pH, concentration and molecular weight of CS, incubation time and reaction temperature). Nanofibers can bind plasmid DNA very well and show a potential to enhance gene transfer in tissue engineering applications [ 136 , 137 ].…”

Section: Polyelectrolyte Complexesmentioning

confidence: 99%

Chitosan Based Self-Assembled Nanoparticles in Drug Delivery

2018

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Abstract:Chitosan is a cationic polysaccharide that is usually obtained by alkaline deacetylation of chitin poly(N-acetylglucosamine). It is biocompatible, biodegradable, mucoadhesive, and nontoxic. These excellent biological properties make chitosan a good candidate for a platform in developing drug delivery systems having improved biodistribution, increased specificity and sensitivity, and reduced pharmacological toxicity. In particular, chitosan nanoparticles are found to be appropriate for non-invasive routes of drug administration: oral, nasal, pulmonary and ocular routes. These applications are facilitated by the absorption-enhancing effect of chitosan. Many procedures for obtaining chitosan nanoparticles have been proposed. Particularly, the introduction of hydrophobic moieties into chitosan molecules by grafting to generate a hydrophobic-hydrophilic balance promoting self-assembly is a current and appealing approach. The grafting agent can be a hydrophobic moiety forming micelles that can entrap lipophilic drugs or it can be the drug itself. Another suitable way to generate self-assembled chitosan nanoparticles is through the formation of polyelectrolyte complexes with polyanions. This paper reviews the main approaches for preparing chitosan nanoparticles by self-assembly through both procedures, and illustrates the state of the art of their application in drug delivery.

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Section: Polyelectrolyte Complexesmentioning

confidence: 99%

Chitosan Based Self-Assembled Nanoparticles in Drug Delivery

2018

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“…Electrospinning has been used to fabricate controlled-release systems to deliver small molecule drugs (Jiang et al 2005;Cui et al 2006;Huang et al 2006;LuongVan et al 2006;Stitzel et al 2006;Taepaiboon et al 2006;Feng et al 2010;Okuda et al 2010), proteins (Reilly and Bruner 2004;Wei et al 2006;Zhang et al 2006;Chiu et al 2007;Jin et al 2008;Maretschek et al 2008;Fletcher et al 2009;Ionescu et al 2010), and nucleic acids (Liang et al 2005;Cao et al 2010;Kim and Yoo 2010;Wang et al 2010). Drug release kinetics from the electrospun matrix can be finely tuned by controlling the nanofeatures (size, geometry, architecture) as well as physicochemical properties of the materials (polymer wetting, swelling, and dissolution as well as drug-polymer interactions).…”

Section: Electrospun Fibersmentioning

confidence: 98%

Microbicide Dosage Forms

Rohan

Devlin

Yang

2013

Current Topics in Microbiology and Immunology

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Microbicides are topically applied, user controlled dosage forms that are being developed to prevent the transmission of HIV during coitus. Early candidates focused on coitally dependent dosage forms such as gels and creams. More recent development has focused on broadening the coitally dependent options through the introduction of films and fast dissolving tablets. Additionally, it has become important to have longer acting products to minimize the burden of user compliance and thus vaginal rings have been developed providing sustained delivery of antiretroviral drugs. This chapter discusses the history of microbicides along with a detailed description of coitally dependent products, gels, films, tablets diaphragms, as well as coitally independent dosage forms such as vaginal rings and the introduction of a new technology, electrospun fibers.

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“…Under these conditions, the size of NPs was 0.477 ± 0.008 nm. Particle sizes of approximately [130][131][132][133][134][135][136][137][138][139][140] nm were obtained at other pH values, but yields were lower than 45 %. It was found that purification by dialysis can provoke a drastic change both in the distribution profile and in the particle size of the complex.…”

Section: Cs-mentioning

confidence: 99%

Chitosan Based Self-assembled Nanoparticles in Drug Delivery

Quiñones

Peniche

Péniche

2018

Preprint

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Chitosan is a cationic polysaccharide usually obtained by alkaline deacetylation of chitin poly(N-acetylglucosamine). It is biocompatible, biodegradable, mucoadhesive and non-toxic. These excellent biological properties make chitosan a good candidate for a platform in developing drug delivery systems having improved biodistribution, increased specificity and sensitivity, and reduced pharmacological toxicity. In particular, chitosan nanoparticles are found to be appropriate for non-invasive routes of drug administration: oral, nasal, pulmonary and ocular routes. These applications are facilitated by the absorption-enhancing effect of chitosan. Many procedures for obtaining chitosan nanoparticles have been proposed. Particularly, the introduction of hydrophobic moieties into chitosan molecules by grafting to generate a hydrophobic-hydrophilic balance promoting self-assembly is a current and appealing approach. The grafting agent can be a hydrophobic moiety forming micelles that can entrap lipophilic drugs or it can be the drug itself. Another suitable way to generate self-assembled chitosan nanoparticles is through the formation of polyelectrolyte complexes with polyanions. This paper reviews the main approaches for preparing chitosan nanoparticles by self-assembly through both procedures and illustrates the state of the art of their application in drug delivery.

show abstract

Effect of experimental parameters on the formation of chitosan–poly(acrylic acid) nanofibrous scaffolds and evaluation of their potential application as DNA carrier

Cited by 7 publications

References 42 publications

Chitosan Based Self-Assembled Nanoparticles in Drug Delivery

Chitosan Based Self-Assembled Nanoparticles in Drug Delivery

Microbicide Dosage Forms

Chitosan Based Self-assembled Nanoparticles in Drug Delivery

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