Effect of experimental propolis-based toothpastes on dentin hypersensitivity: a randomized clinical trial

Abstract

Background: Propolis is a natural product produced by bees, which has garnered attention due to its harmlessness and numerous beneficial biological properties. This randomized, double-blinded, placebo-controlled clinical trial aimed to assess the effect of toothpastes containing different concentrations of propolis (10% and 15%) on the control of dentin hypersensitivity (DH). Methods: Sixty-six teeth with DH were randomly divided into three treatment groups (n= 22): placebo (toothpaste without active ingredient), 10% propolis (toothpaste with 10% propolis), and 15% propolis (toothpaste with 15% propolis). DH was assessed at three distinct time points (baseline, 15 and 30 days after treatment) by tactile and evaporative stimuli, using the visual analog scale (VAS). Data were analyzed using Friedman and Kruskal-Wallis tests. A significance level of 5% was used in all analyses. Results: All the groups showed reduction in DH during the study period (p < 0.05). The experimental groups (10% and 15% propolis) showed significantly greater reduction in DH compared to the placebo group (p < 0.05) after 30 days of treatment; however, the findings of experimental groups were similar to each other (p > 0.05). Conclusion: Toothpastes containing propolis at concentrations of 10% and 15% were equally effective in controlling DH, regardless of their concentration. Trial registration: Registered on NCT05083052. Date of Registration: 19/10/2021