Effect of extraction method on the yield of furanocoumarins from fruits of <i>Archangelica ofﬁcinalis</i> Hoffm.

Waksmundzka‐Hajnos, Monika; Petruczynik, Anna; Dragan, A.; Wianowska, Dorota; Dawidowicz, Andrzej L.

doi:10.1002/pca.784

Cited by 57 publications

(38 citation statements)

References 22 publications

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“…lobata, and A. archangelica) were selected. The extracts were prepared in order to insure that they contain the metabolites that are ingested when the medicinal plant is orally taken: a methanolic extract of the fruits from A. archangelica mostly composed of furanocoumarins [43,44], a decoction of aerial parts of W. indica containing quinoline alkaloids [33], and a decoction of roots of P. montana var. lobata with flavonoid glycosides [35].…”

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confidence: 99%

Prediction of the Passive Intestinal Absorption of Medicinal Plant Extract Constituents with the Parallel Artificial Membrane Permeability Assay (PAMPA)

et al. 2016

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At the early drug discovery stage, the high-throughput parallel artificial membrane permeability assay is one of the most frequently used in vitro models to predict transcellular passive absorption. While thousands of new chemical entities have been screened with the parallel artificial membrane permeability assay, in general, permeation properties of natural products have been scarcely evaluated. In this study, the parallel artificial membrane permeability assay through a hexadecane membrane was used to predict the passive intestinal absorption of a representative set of frequently occurring natural products. Since natural products are usually ingested for medicinal use as components of complex extracts in traditional herbal preparations or as phytopharmaceuticals, the applicability of such an assay to study the constituents directly in medicinal crude plant extracts was further investigated. Three representative crude plant extracts with different natural product compositions were chosen for this study. The first extract was composed of furanocoumarins (Angelica archangelica), the second extract included alkaloids (Waltheria indica), and the third extract contained flavonoid glycosides (Pueraria montana var. lobata). For each medicinal plant, the effective passive permeability values Pe (cm/s) of the main natural products of interest were rapidly calculated thanks to a generic ultrahigh-pressure liquid chromatography-UV detection method and because Pe calculations do not require knowing precisely the concentration of each natural product within the extracts. The original parallel artificial membrane permeability assay through a hexadecane membrane was found to keep its predictive power when applied to constituents directly in crude plant extracts provided that higher quantities of the extract were initially loaded in the assay in order to ensure suitable detection of the individual constituents of the extracts. Such an approach is thus valuable for the high-throughput, cost-effective, and early evaluation of passive intestinal absorption of active principles in medicinal plants. In phytochemical studies, obtaining effective passive permeability values of pharmacologically active natural products is important to predict if natural products showing interesting activities in vitro may have a chance to reach their target in vivo.

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confidence: 99%

Prediction of the Passive Intestinal Absorption of Medicinal Plant Extract Constituents with the Parallel Artificial Membrane Permeability Assay (PAMPA)

et al. 2016

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“…Because of previous reports, that methanol was the best extractant for the furanocoumarins [10,22], this solvent (100% methanol and 80% aqueous solution of methanol) was used in our experiments. Results of the investigation (Table II) showed that extraction in Soxhlet apparatus was the most efficient for the isolation of isopimpinellin and umbelliferone, while ASE gave the highest yield of xanthotoxin, pimpinellin (100 °C, 100% methanol as extractant) and bergapten (80 °C, 80% aqueous solution of methanol as extractant).…”

Section: Resultsmentioning

confidence: 99%

“…Traditional liquid-solid extraction (LSE) procedures (e.g., Soxhlet extraction and percolation) are generally labor-intensive and time-and solvent-consuming methods. New liquid-solid extraction methods (LSE) such as microwave-assisted solvent extraction (MASE), accelerated solvent extraction (ASE), and ultrasoundassisted extraction (USAE) require shorter extraction time and the use of low amount of solvents, allow for simultaneous parallel processing of several samples, and are automatic but are more expensive due to special equipment devices [9,10]. The important step in sample preparation is the purification of crude extract usually by solid-phase extraction (SPE) or more rarely by liquid-liquid extraction (LLE).…”

Section: Introductionmentioning

confidence: 99%

Comparison of Matrix Solid-Phase Dispersion and Liquid—Solid Extraction Methods Followed by Solid-Phase Extraction in the Analysis of Selected Furanocoumarins fromPimpinellaRoots by HPLC—DAD

Oniszczuk

Waksmundzka‐Hajnos

Podgórski

et al. 2015

Acta Chromatographica

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Summary. The use of matrix solid-phase dispersion (MSPD) was tested to extract some coumarins (umbelliferone, xanthotoxin, isopimpinellin, bergapten, and pimpinellin) from Pimpinella roots. The method was compared with liquid-solid extraction methods (LSE) such as accelerated solvent extraction (ASE), ultrasound-assisted extraction (USAE) and Soxhlet extraction followed by solid-phase extraction (SPE). Several methanol concentrations and temperature conditions were examined during the liquidsolid extraction techniques. The analysis was performed by high-performance liquid chromatography with diode array detector (HPLC-DAD). MSPD extracted furanocoumarins with satisfactory recoveries ranging from 91.65% to 97.55% and relative standard deviations lower than 5,0415%. The results presented in the paper reveal that MSPD is an efficient, fast, simple and easy-to-perform method suitable for the isolation of furanocoumarins from herbs.

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“…This study indicated the highest yield of psoralens by ASE, using methanol or petroleum ether as the extractant. It was also reported that microwave-assisted solvent extraction in the closed system probably causing the change of analytes (Waksmundzka-Hajnos et al, 2004a).…”

Section: Waksmundzka-hajnos Et Al (2004) Compared Methods Of Extractmentioning

confidence: 99%

Analytical Methods for Isolation, Separation and Identification of Selected Furanocoumarins in Plant Material

Szewczyk¹,

Kocka²

2012

Phytochemicals - A Global Perspective of Their Role in Nutrition and Health

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Effect of extraction method on the yield of furanocoumarins from fruits of Archangelica ofﬁcinalis Hoffm.

Cited by 57 publications

References 22 publications

Prediction of the Passive Intestinal Absorption of Medicinal Plant Extract Constituents with the Parallel Artificial Membrane Permeability Assay (PAMPA)

Prediction of the Passive Intestinal Absorption of Medicinal Plant Extract Constituents with the Parallel Artificial Membrane Permeability Assay (PAMPA)

Comparison of Matrix Solid-Phase Dispersion and Liquid—Solid Extraction Methods Followed by Solid-Phase Extraction in the Analysis of Selected Furanocoumarins fromPimpinellaRoots by HPLC—DAD

Analytical Methods for Isolation, Separation and Identification of Selected Furanocoumarins in Plant Material

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