Effect of Extracts of Bilberries (Vaccinium myrtillus L.) on Amyloglucosidase and α-Glucosidase Activity

Karcheva-Bahchevanska, Diana; Lukova, Paolina; Nikolova, M; Mladenov, Rumen; Iliev, Ilia

doi:10.1515/folmed-2017-0028

Cited by 20 publications

(14 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These fruits are recognized as rich natural sources of polyphenols and other bioactive compounds with health benefits. Among others, antioxidant, anti-obesity, anti-proliferative, cardioprotective, antiinflammatory, ocular, hypoglycemic and antibacterial effects have been associated with consuming bilberry fruits [60][61][62]. The numerous scientific studies that support the beneficial effects associated with these fruits explain the increase in the production and consumption of novel products and dietary supplements containing bilberry [63].…”

Section: Health Benefitsmentioning

confidence: 99%

Vaccinium myrtillus L. Fruits as a Novel Source of Phenolic Compounds with Health Benefits and Industrial Applications - A Review

Pires

Caleja

Santos‐Buelga

et al. 2020

CPD

View full text Add to dashboard Cite

: Consumers’ demand for healthier foods with functional properties has had a clear influence on the food industry and in this sense, they have been attaching natural sources of bioactive ingredients into food products. Vaccinium myrtillus L. (bilberry) is known to be a functional food, presenting its fruits in the form of a small dark blueberry. This coloration is due to its high content in anthocyanin, being also associated with bilberries’ beneficial health effects. In the bilberry industry, there is a very high annual loss of this fruit due to the less aesthetic shape or appearance, in which they cannot be considered suitable for sale and are therefore disposed of as biological waste. Therefore, it is of great importance to valorize this fruit and this review aimed to completely characterize the fruits of V. myrtillus in order to comprehend the relationship between their consumption and the beneficial effects regarding consumer’s health. Thus, this review provides a description of the nutritional and bioactive compounds present in bilberry fruits, followed by their beneficial health effects. An overview of the natural pigments present in these fruits was also explored, focusing particularly in the anthocyanins composition, which represents the most widely studied class of bioactive compounds of V. myrtillus fruits. Finally, industrial applications of these fruits and by-products, as an efficient approach to the production of value-added products with economical and environmental impact, were also discussed. : In general, V. myrtillus is a rich source of micronutrients and phytochemical compounds, such as organic acids, sugars, vitamins, fibers and phenolic compounds (anthocyanin and non-anthocyanin compounds), with nutritional and functional properties, that justify the growing interest in these berries, not only for food applications, but also in the pharmaceutical industry.

show abstract

Section: Health Benefitsmentioning

confidence: 99%

Vaccinium myrtillus L. Fruits as a Novel Source of Phenolic Compounds with Health Benefits and Industrial Applications - A Review

Pires

Caleja

Santos‐Buelga

et al. 2020

CPD

View full text Add to dashboard Cite

show abstract

“…Starting from the fact that plants with high phenolic content have strong antioxidant power [19], and due to the few data regarding the use of plant leaves as additives in the diets of laying hens and their nutritional assessment, in this study, we have chosen to use bilberry and walnut leaves powder. Vaccinium myrtillus is a species of the genus Vaccinium from the family Ericaceae [20]. Fruit and aerial parts of plant are known as a natural source of food and drink due to their richness in nutritional and antioxidant compounds and can also be integrated into food supplements and pharmaceuticals for preventing urinary tract infections [21] and cerebral vascular accidents [22].…”

Section: Introductionmentioning

confidence: 99%

Effects of Dietary Inclusion of Bilberry and Walnut Leaves Powder on the Digestive Performances and Health of Tetra SL Laying Hens

Popescu

Voicu

Pîrcălăbioru

et al. 2020

Animals

View full text Add to dashboard Cite

The purpose of this study was to examine the effects of dietary inclusion of two additives at the final concentration of 0.5% bilberry (E1) and 1% walnut (E2) leaves powder in the basal diet on digestive health of hens. A total number of 90 Tetra SL hens were divided into two experimental groups (E1 and E2) and one control group (C) consisting of 30 hens each. After four weeks, 10 hens of each group were sacrificed and tissue samples and intestinal content were taken from the duodenum, jejunum, and cecum in order to perform histological, enzymatic, and microbiota analyses. In groups E1 and E2, the histological analysis showed a significant increase of villus height, resulting probably in increased absorption of nutrients in duodenum and jejunum. A decrease in the specific activity of alpha-amylase and trypsin in E1 and E2 for both duodenum and jejunum compared to the control one was also recorded. In addition, the maltase and invertase specific activity in duodenum increased, a tendency that was kept for maltase but not for invertase in jejunum. The cecal microbiota of E1 and E2 individuals was characterized by an increase of Firmicutes and Lactobacilli and a decrease of Enterobacteriaceae. In conclusion, our results indicate that bilberry and walnut leaves additives in feed may improve the health status of the poultry gastrointestinal tract.

show abstract

“…The capacity of strawberry and blueberry fruits or leaves to inhibit α-glucosidase and α-amylase activity has been shown [19,20,44,45], and our study is the first that demonstrates that leaf extracts of Fragaria, Vaccinium, and Rubus are also efficient in vitro inhibitors of α-glucosidase and α-amylase enzyme activitiy. Leaf extracts are not only cheap alternatives of fruit extracts as inhib- itors of enzymes, but also contain higher amounts of phenolic compounds, which are related to antihyperglycemic effects.…”

Section: Discussionmentioning

confidence: 57%

“…Polyphenol-rich extracts from bilberry fruits have also been found to be effective inhibitors of α-glucosidase [20]. The antidiabetic activity of the berries was confirmed in individuals with metabolic syndome [21].…”

Section: Introductionmentioning

confidence: 93%

Wild Strawberry, Blackberry, and Blueberry Leaf Extracts Alleviate Starch-Induced Hyperglycemia in Prediabetic and Diabetic Mice

et al. 2020

View full text Add to dashboard Cite

Intestinal α-glucosidase and α-amylase break down nutritional poly- and oligosaccharides to monosaccharides and their activity significantly contributes to postprandial hyperglycemia. Competitive inhibitors of these enzymes, such as acarbose, are effective antidiabetic drugs, but have unpleasant side effects. In our ethnopharmacology inspired investigations, we found that wild strawberry (Fragaria vesca), blackberry (Rubus fruticosus), and European blueberry (Vaccinium myrtillus) leaf extracts inhibit α-glucosidase and α-amylase enzyme activity in vitro and are effective in preventing postprandial hyperglycemia in vivo. Toxicology tests on H9c2 rat embryonic cardiac muscle cells demonstrated that berry leaf extracts have no cytotoxic effects. Oral administration of these leaf extracts alone or as a mixture to normal (control), obese, prediabetic, and streptozotocin-induced diabetic mice attenuated the starch-induced rise of blood glucose levels. The efficiency was similar to that of acarbose on blood glucose. These results highlight berry leaf extracts as candidates for testing in clinical trials in order to assess the clinical significance of their effects on glycemic control.

show abstract

Effect of Extracts of Bilberries (Vaccinium myrtillus L.) on Amyloglucosidase and α-Glucosidase Activity

Abstract: The inhibitory activity of bilberries' extracts towards α-glucosidase offers the patients with type 2 diabetes the opportunity to manage their own glycaemic levels with a diet.

Cited by 20 publications

References 18 publications

Vaccinium myrtillus L. Fruits as a Novel Source of Phenolic Compounds with Health Benefits and Industrial Applications - A Review

Vaccinium myrtillus L. Fruits as a Novel Source of Phenolic Compounds with Health Benefits and Industrial Applications - A Review

Effects of Dietary Inclusion of Bilberry and Walnut Leaves Powder on the Digestive Performances and Health of Tetra SL Laying Hens

Wild Strawberry, Blackberry, and Blueberry Leaf Extracts Alleviate Starch-Induced Hyperglycemia in Prediabetic and Diabetic Mice

Contact Info

Product

Resources

About