Effect of extracts of Gratiola officinalis and Zea mays on the tumor and the morphology of the internal organs of rats with transplanted liver cancer

Navolokin, Nikita A.; Polukonova, N. V.; Maslyakova, Gаlina N.; Bucharskaya, Alla B.; Дурнова, Н. А.

doi:10.15275/rusomj.2012.0203

Cited by 18 publications

(19 citation statements)

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“…Therefore, extracts the compared methods represent different biological active compositions with different classes of toxicity [5,[10][11][12].…”

Section: Resultsmentioning

confidence: 99%

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A new extraction method of bioflavanoids from poisonous plant (Gratiola Officinalis L.)

Polukonova¹,

Kurchatova²,

Navolokin³

et al. 2014

RusOMJ

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Abstract:The way of vegetable raw materials extraction which allows to receive nontoxical composition of biological active agents from poisonous plants such as Gratiola officinalis L. was described. The alkaloids exit changes with the increase of ethyl alcohol percentage (from 15% to 96%). The extract was obtained using 96% ethanol and did not give positive high quality reaction to the content of alkaloids. The chemical composition with new nontoxical biological active composition of Gratiola officinalis L. extract was investigated. The extract contains a previously unknown plant -bioflavonoid quercetin. The average value of quercetin in this extract using the calibration curve of the standard sample quercetin (98%) Sigma is 0.66%. In the dry rest of extractive substances (Gratiola officinalis L.) the quantity of quercetin was 350 mkg (obtained from 10 g of a dry grass) as was established by the method of a liquid chromatography.

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“…Therefore, extracts the compared methods represent different biological active compositions with different classes of toxicity [5,[10][11][12].…”

Section: Resultsmentioning

confidence: 99%

“…We have already described the positive effects of Gratiola officinalis L. on the organism of animals with transplanted liver cancer and at the same time, the negative cytotoxic and cytostatic effects on tumor cells [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

A new extraction method of bioflavanoids from poisonous plant (Gratiola Officinalis L.)

Polukonova¹,

Kurchatova²,

Navolokin³

et al. 2014

RusOMJ

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“…Previously, we have developed a method for producing flavonoid-containing extracts from Gratīola officinālis, Helichrýsum arenárium, and Zea mays, that allows obtaining non-toxic or slightly toxic extracts even from poisonous plants [3][4][5][6]. It is know that these extracts have antioxidant, antitumor, immunomodulatory [7][8][9][10][11] and antimicrobial [12][13][14] actions.…”

Section: Introductionmentioning

confidence: 99%

Effect of flavonoid-containing extracts on the growth of transplanted sarcoma 45, peripheral blood and bone marrow condition after oral and intramuscular administration in rats

Navolokin¹,

Mudrak²,

Alla³

et al. 2017

Russ Open Med J

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Abstract:Objective -Discovery of the apoptosis-inducing effects of flavonoid vagonin allowed to make an assumption of existence of similar effect in others flavonoids. This study of the effects of extracts from Gratīola officinālis, Helichrýsum arenárium and diploid forms of Zea mays on bone marrow and blood leucocytes at intramuscular and oral administration was carried out on rats bearing sarcoma 45. Earlier, the apoptosis-inducing effects were detected for these extracts but the toxic effects of extracts on blood and bone marrow have not been studied. Therefore, the aim of this study was to investigate the effects of these extracts on white blood cell count and bone marrow morphology. Material and Methods -The experiments were carried out on 48 male Wistar albino rats according to University's Animal Ethics Committee (Protocol № 13, 2011, Saratov, Russia) and the relevant national agency regulating experiments on animals. We evaluated white blood cell count and bone marrow morphology in animals after oral and intramuscular administration of extracts. A growth rate of tumor was also ranked. Results -Oral and intramuscular administration of extracts from flavonoid-containing plants Zea mays and Gratīola officinālis causes normalization of myelocytic germ parameters in bone marrow of tumor-bearing rats and increase of lymphocyte percent in white blood cell count of blood and myelogram. Conclusion -Absence of toxic effects and normalization of myelocytic germ parameters in bone marrow of tumor-bearing rats after oral and intramuscular administration of extracts from flavonoid-containing plants Zea mays and Gratīola officinālis allows to recommend further study of the antitumor effect of these extracts.Keywords: flavonoids, Gratīola officinālis, Helichrýsum arenárium, Zea mays, bone marrow, blood, sarcoma 45Cite as Navolokin NA, Mudrak DA, Bucharskaya AB, Matveeva OV, Tychina SA, Polukonova NV, Maslyakova GN. Effect of flavonoid-containing extracts on the growth of transplanted sarcoma 45, peripheral blood and bone marrow condition after oral and intramuscular administration in rats.

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“…Метод экстракции, направленный на снижение токсичности и большему выходу флавоноидов (RU 2482863;Navolokin et al, 2012;Наволокин и др., 2012Полуконова и др.,2013;Polukonova et al, 2014), в отношении Кипрея узколистного ранее не применялся. Между тем, получены данные о том, что экстракты, полученные таким спосо-бом, обладают противовоспалительным, жаропонижающим, антимик-робным, противотуберкулезным, противоопухолевым и антикахекти-ческим свойствами (Наволокин и др., 2013, 2015, 2016 а, б, в; Курчато-ва и др., 2014; Полуконова и др., 2015).…”

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Investigation of the activity of the flavonoid-containing Chamerion angustifolium extract in the experiments in vitro and in vivo.

Gelevera¹,

Polukonova²,

Baitman³

et al. 2017

BBG

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Effect of extracts of Gratiola officinalis and Zea mays on the tumor and the morphology of the internal organs of rats with transplanted liver cancer

Cited by 18 publications

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A new extraction method of bioflavanoids from poisonous plant (Gratiola Officinalis L.)

A new extraction method of bioflavanoids from poisonous plant (Gratiola Officinalis L.)

Effect of flavonoid-containing extracts on the growth of transplanted sarcoma 45, peripheral blood and bone marrow condition after oral and intramuscular administration in rats

Investigation of the activity of the flavonoid-containing Chamerion angustifolium extract in the experiments in vitro and in vivo.

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