Effect of Extractum Cepae, Heparin Sodium and Allantoin Combination (Contractubex) on Adhesion and Fibrosis After Neck Surgery (Thyroidectomy) in Rats

Abstract

OBJECTIVE Reoperative thyroid surgery is technically difficult process with increased complications due to the adhesions and fibrosis caused by the previous surgery. In this experimental animal model, we planned to investigate the effect of Contracttubex TM , a mixture of Extractum cepae, Heparin sodium and Allantoin, on adhesion and fibrosis after neck surgery (thyroidectomy). METHODS The current study is an experimental animal model of post-thyroidectomy adhesion. Twelve Wistar-Albino male rats in two groups were used. Under sterile conditions, a midline incision on the neck was made. The anterior thyroid muscles were separated and the thyroid lodge was reached. As a minor interventional procedure, a sponge was applied to the thyroid tissue, and then a combination of 1 g Extractum capae, heparin, sodium, and allantoin was applied to the dissection site in the drug group. Rats in both groups were sacrificed on 30 th day. Cervical regions were dissected and evaluated for macroscopic adhesion. Tissue samples were taken for microscopic evaluation for fibrosis and inflammation. RESULTS In the experimental group in which Contractubex TM was applied, inflammation was not detected in five (83.3%) of six rats while no inflammation was detected in four (66.7%) of six rats in the control group (p=0.505). Considering the fibrosis score, mild or moderate fibrosis was detected in four (66.7%) of six rats in the control group, while fibrosis was found in only two (33.3%) rats in the experimental group (p=0.264). When macroscopic adhesion was evaluated, two (33.3%) rats of the control group subjects were Grade 4, and one (16.7%) was Grade 3. No rats in the experimental group were Grade 4 (p=0.392). CONCLUSION Contractubex TM seems to be effective in preventing adhesions and fibrosis after thyroidectomy and neck surgery, but further research is needed for use in human studies.

Effect of Contractubex phonophoresis on postsurgical scar of carpal tunnel release: A case report

“…Secondary surgeries carry significant risks because of adhesion and fibrosis. 14 Scars cause discomfort, itching, contracture, pain, functional impairment, and cosmetic concern. 15 Scar spread to the connective tissue beneath the skin and muscles and decrease range of motion of joint and impair daily activities.…”

“…In this case author focused on scar management because hypertrophic scars after OCTR can lead to failure of surgery and secondary surgery. Secondary surgeries carry significant risks because of adhesion and fibrosis 14 . Scars cause discomfort, itching, contracture, pain, functional impairment, and cosmetic concern 15 .…”