Effect of extremely low frequency electromagnetic field parameters on the proliferation of human breast cancer

Wang, Min Haw; Chen, Kuan Wei; Ni, Ding Xung; Fang, Hao; Jang, Ling Sheng; Chen, Chun Hong

doi:10.1080/15368378.2021.1891093

Cited by 23 publications

(23 citation statements)

References 33 publications

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“…For the MDA-MB-231 cell line, such a reduction was not observed (Figure 3). A similar effect of the extremely low-frequency electromagnetic field (ELF-EMF) on the proliferation of human breast cancer cells was observed by Wang et al [20]. The application of MNPs facilitated the transmission of mechanical forces and thus, increased the cytotoxic effect on cell proliferation.…”

Section: Magneto-mechanical Activationsupporting

confidence: 62%

Cell Behavioral Changes after the Application of Magneto-Mechanical Activation to Normal and Cancer Cells

et al. 2022

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In vitro cell exposure to nanoparticles, depending on the applied concentration, can help in the development of theranostic tools to better detect and treat human diseases. Recent studies have attempted to understand and exploit the impact of magnetic field-actuated internalized magnetic nanoparticles (MNPs) on the behavior of cancer cells. In this work, the viability rate of MNP’s-manipulated cancerous (MCF-7, MDA-MB-231) and non-cancerous (MCF-10A) cells was investigated in three different types of low-frequency magnetic fields: static, pulsed, and rotating field mode. In the non-cancerous cell line, the cell viability decreased mostly in cells with internalized MNPs and those treated with the pulsed field mode. In both cancer cell lines, the pulsed field mode was again the optimum magnetic field, which together with internalized MNPs caused a large decrease in cells’ viability (50–55% and 70% in MCF-7 and MDA-MB-231, respectively) while the static and rotating field modes maintained the viability at high levels. Finally, F-actin staining was used to observe the changes in the cytoskeleton and DAPI staining was performed to reveal the apoptotic alterations in cells’ nuclei before and after magneto-mechanical activation. Subsequently, reduced cell viability led to a loss of actin stress fibers and apoptotic nuclear changes in cancer cells subjected to MNPs triggered by a pulsed magnetic field.

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Section: Magneto-mechanical Activationsupporting

confidence: 62%

Cell Behavioral Changes after the Application of Magneto-Mechanical Activation to Normal and Cancer Cells

et al. 2022

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“…Studies related to body i.e. in vivo, showed that cellular processes can be raised and cancer cell growth prohibition, and induction of apoptosis can be maintained through exposure of MDA-MB-231 cells to Extremely Low-Frequency Electromagnetic Field (ELF-EMF) [34].…”

Section: Oxidative Stress and Apoptosismentioning

confidence: 99%

“…Specific pulsed electromagnetic fields on in vitro proliferation of MCF-7 adenocarcinoma cells and MDA-MB-231 breast cancer cells and an M10 non-cancerous breast epithelial cell can affects cellular processes and inhibits the growth of cancer cells and may offer a potential anti-cancer treatment in the future [34].…”

Section: Tumorigenesismentioning

confidence: 99%

Cell Biological Effects of Long-term Exposure to Electromagnetic Field of Simulated Mobile Phones

Oskouei

Khodahemmati

et al. 2022

IOP Conf. Ser.: Earth Environ. Sci.

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Living in today’s world requires extensive communication with the world around us, which the mobile phone is one of this equipment along with other devices such as computers, radios, telephone towers, and power lines. It is supposed that prolonged exposure to radiation may cause biological damage to living organisms. However, the results from different laboratory studies are contradictory and there is still insufficient information about the biological risks to human health. In this article, we reviewed some of the potential biological effects of Radiofrequency Electromagnetic Field (RF-EMF) exposure.

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“…In most in vitro experiments, the low-frequency magnetic field showed a significant inhibitory effect on tumor cells 2 , 3 , 19 – 23 and did not affect the growth of normal cells 2 , 24 . A report found that the magnetic field affected the surface of the tumor membrane, thus influencing tumor proliferation 25 .…”

Section: Introductionmentioning

confidence: 99%

Effects of extremely low frequency electromagnetic fields on the tumor cell inhibition and the possible mechanism

Sun

Tong

et al. 2023

Sci Rep

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Low-frequency magnetic fields exert a significant inhibitory effect on tumor growth and have been developed as a therapeutic modality. However, the effect of a low-frequency magnetic field on the interaction between cells is still poorly understood. This study aimed to preliminarily evaluate the direct effect of magnetic field ditectely on cultured cells and indirect effect mediated by cell-environment (conditioned medium). 293 T cells, Hepg2 cells, A549 cells have been cultured at 37 ± 0.18 °C in presence of an extremely low-frequency magnetic field of 20 Hz, 5-mT. The adherent tumor cells were more sensitive to magnetic field inhibition in the original environment (conditioned medium) with adherence inhibition rate for Hepg2 and A549 estimated at 18% and 30% respectively. The inhibition effect was suppressed when the suspended cells separated or clump density at a low density. The nontumor cell lines showed no inhibitory effect on exposure to a low-frequency magnetic field. The intracellular ion fluorescence (IIF) showed that the magnetic field significantly altered the membrane potential, indicating hyperpolarization of the adherent cells (ΔIIF 293 T cells: − 25%, ΔIIF Hepg2 cells: − 20% and ΔIIF A549 cells: − 13%) and depolarization of the suspended cells (ΔIIF Raji cells: + 9%). In addition, the conditioned media collected after magnetic field exposure acted on unexposed tumor cells and caused inhibition. Our findings might provide a basis for the mechanism of magnetic field interaction between cells and cell environment in the future.

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Effect of extremely low frequency electromagnetic field parameters on the proliferation of human breast cancer

Cited by 23 publications

References 33 publications

Cell Behavioral Changes after the Application of Magneto-Mechanical Activation to Normal and Cancer Cells

Cell Behavioral Changes after the Application of Magneto-Mechanical Activation to Normal and Cancer Cells

Cell Biological Effects of Long-term Exposure to Electromagnetic Field of Simulated Mobile Phones

Effects of extremely low frequency electromagnetic fields on the tumor cell inhibition and the possible mechanism

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