Effect of Falls on Frequency of Atrial Fibrillation and Mortality Risk (from the REasons for Geographic And Racial Differences in Stroke Study)

O’Neal, Wesley T.; Qureshi, Waqas; Judd, Suzanne E.; Bowling, C. Barrett; Howard, Virginia J.; Howard, George; Soliman, Elsayed Z

doi:10.1016/j.amjcard.2015.07.036

Cited by 27 publications

(9 citation statements)

References 31 publications

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“…Compared with those with neither AF nor falls, those with both conditions had an adjusted 2-fold increased risk of death (HR, 2.12; 95% CI, 1.64–2.74). 125 …”

Section: Disorders Of Heart Rhythmmentioning

confidence: 99%

Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association

Benjamin¹,

Blaha²,

Chiuve³

et al. 2017

Circulation

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5,040

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“…Compared with those with neither AF nor falls, those with both conditions had an adjusted 2-fold increased risk of death (HR, 2.12; 95% CI, 1.64–2.74). 125 …”

Section: Disorders Of Heart Rhythmmentioning

confidence: 99%

Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association

Benjamin¹,

Blaha²,

Chiuve³

et al. 2017

Circulation

Self Cite

7,731

5,040

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“…Compared with those with neither AF nor falls, those with both conditions had an adjusted 2-fold increased risk of death (HR, 2.12 [95% CI, 1.64–2.74]). 242…”

Section: Af and Atrial Fluttermentioning

confidence: 99%

Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association

Tsao¹,

Aday²,

Almarzooq³

et al. 2022

Circulation

3,830

2,336

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Background: The American Heart Association, in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, diet, and weight) and health factors (cholesterol, blood pressure, and glucose control) that contribute to cardiovascular health. The Statistical Update presents the latest data on a range of major clinical heart and circulatory disease conditions (including stroke, congenital heart disease, rhythm disorders, subclinical atherosclerosis, coronary heart disease, heart failure, valvular disease, venous disease, and peripheral artery disease) and the associated outcomes (including quality of care, procedures, and economic costs). Methods: The American Heart Association, through its Statistics Committee, continuously monitors and evaluates sources of data on heart disease and stroke in the United States to provide the most current information available in the annual Statistical Update. The 2022 Statistical Update is the product of a full year’s worth of effort by dedicated volunteer clinicians and scientists, committed government professionals, and American Heart Association staff members. This year’s edition includes data on the monitoring and benefits of cardiovascular health in the population and an enhanced focus on social determinants of health, adverse pregnancy outcomes, vascular contributions to brain health, and the global burden of cardiovascular disease and healthy life expectancy. Results: Each of the chapters in the Statistical Update focuses on a different topic related to heart disease and stroke statistics. Conclusions: The Statistical Update represents a critical resource for the lay public, policymakers, media professionals, clinicians, health care administrators, researchers, health advocates, and others seeking the best available data on these factors and conditions.

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“…Furthermore, the current study was able to replicate these findings while addressing some of the limitations inherent to some previous studies, such as short follow-up, small sample sizes, or limited comorbidity adjustment. Atrial fibrillation has also been shown to be associated with a history of falls in a study examining the relationships between falls history, atrial fibrillation, and mortality ( 20 )—furthermore, it has also been linked to fracture risk in a large population-based study with robust comorbid adjustment ( 21 ) and also in the work by Kapral et al investigating fracture risk after stroke ( 19 ). Atrial fibrillation is positively associated with fractures at 366–1,095 days poststroke (HR > 1), but shows a HR < 1 for the time interval 1,096–1,825 days poststroke.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Factors Associated With Falls and Fractures Poststroke

et al. 2018

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BackgroundRisk factors for poststroke falls and fractures remain poorly understood. This study aimed to evaluate which factors increased risk of these events after stroke.MethodsData from 7,267 hospitalized stroke patients were acquired from the Norfolk and Norwich University Hospital Stroke Register from 2003–2015. The impacts of multiple patient level and stroke characteristics and comorbidities on post-discharge falls and fractures were assessed. Univariate and multivariable models were constructed, adjusting for multiple confounders, using binary logistic regression for short-term analysis (up to 1-year post-discharge) and Cox-proportional hazard models for longer term analysis (1–3, 3–5, and 0–10 years follow-up).ResultsThe mean age (SD) was 76.3 ± 12.1 years at baseline. 1,138 (15.7%) participants had an incident fall; and 666 (9.2%) an incident fracture during the 10-year follow-up (total person years = 64,447.99 for falls and 67,726.70 for fractures). Half of the sample population were females (50.6%) and the majority had an ischemic stroke (89.8%). After adjusting for confounders: age, sex, previous history of falls, and atrial fibrillation were associated with an increased risk of both falls and fractures during follow-up. Furthermore, chronic kidney disease and hyperlipidemia were associated with an increased risk of falls, while previous stroke/transient ischemic attack increased fracture risk. Total anterior circulation stroke and a prestroke modified Rankin Scale score of 3–5 were associated with decreased risk of both events, with hypertension and cancer decreasing risk of falls only.ConclusionWe identified demographic, stroke-related, and comorbid factors associated with poststroke falls and fracture incidence. Further studies are required to examine and establish the relationship between reversible factors and further explore the role of preventative measures to prevent poststroke falls and fractures.

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Effect of Falls on Frequency of Atrial Fibrillation and Mortality Risk (from the REasons for Geographic And Racial Differences in Stroke Study)

Cited by 27 publications

References 31 publications

Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association

Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association

Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association

Long-Term Factors Associated With Falls and Fractures Poststroke

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