Effect of fasting on the uptake of bilirubin and sulfobromophthalein by the isolated perfused rat liver

Gärtner, Ulrich; Goeser, Tobias; Wolkoff, A. Stark

doi:10.1053/gast.1997.v113.pm9352876

Cited by 51 publications

(30 citation statements)

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“…In contrast, measurements of pulmonary excretion of carbon monoxide (an index of bilirubin production) showed no effect of caloric deprivation on bilirubin production. 19 A recent article by Gärtner et al 20 investigated the effect of fasting in rats using a technique that ⅷ P Ͻ .001 among infants with TSB Ͼ12.9 mg/dL and all infants studied. □ P Ͻ .01 among supplementary and breastfed infants.…”

Section: Discussionmentioning

confidence: 99%

Is Breastfeeding Really Favoring Early Neonatal Jaundice?

et al. 2001

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ABSTRACT. Objective. The purpose of this study was to evaluate the development of significant hyperbilirubinemia in a large unselected newborn population in a metropolitan area with particular attention to the relationship between type of feeding and incidence of neonatal jaundice in the first week of life.Study Design. A population of 2174 infants with gestational age >37 weeks was prospectively investigated during the first days of life. Total serum bilirubin determinations were performed on infants with jaundice. The following variables were studied: type of feeding, method of delivery, weight loss after birth in relationship to the type of feeding, and maternal and neonatal risk factors for jaundice. Statistical analyses were performed using the z test for parametric variables and the t test for nonparametric variables. In addition, the multiple logistic regression allows for the estimation of the role of the individual characteristics in the development of hyperbilirubinemia. Data concerning serum bilirubin peak distribution in jaundiced newborns were analyzed using a single and a double Gaussian best fit at least squares. The t test was performed to compare 2 values (high and low) of the serum bilirubin peak in breastfed and supplementary-fed infants with those in bottle-fed infants.Results. The maximal serum bilirubin concentration exceeded 12.9 mg/dL (221 mol/L) in 112 infants (5.1%). The study demonstrated a statistically significant positive correlation between patients with a total serum bilirubin concentration >12.9 mg/dL (221 mol/L) and supplementary feeding; oppositely, breastfed neonates did not present a higher frequency of significant hyperbilirubinemia in the first days of life. However, best Gaussian fitting of our data suggests that a small subpopulation of breastfed infants have a higher serum bilirubin peak than do bottle-fed infants.Newborns with significant hyperbilirubinemia underwent a greater weight loss after birth compared with the overall studied population, and infants given mixed feeding lost more weight than breastfed and formula-fed newborns, indicating that formula has been administered in neonates who had a weight loss beyond a predetermined percentage of birth weight. Significant hyperbilirubinemia was also strongly associated with delivery by vacuum extractor, some perinatal complications (cephalohematoma, positive Coombs' test, and blood group systems of A, AB, B, and O [ABO] incompatibility) and Asian origin. Multiple logistic regression analysis shows that supplementary feeding, weight loss percentage, ABO incompatibility, and vacuum extraction significantly increase the risk of jaundice, while only cesarean section decreases the risk.Conclusion. The present study confirms the important role of fasting in the pathogenesis of neonatal hyperbilirubinemia, although breastfeeding per se does not seem related to the increased frequency of neonatal jaundice but to the higher bilirubin level in a very small subpopulation of infants with jaundice. In fact, in the breastfed infant...

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Section: Discussionmentioning

confidence: 99%

Is Breastfeeding Really Favoring Early Neonatal Jaundice?

et al. 2001

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“…12 In many breastfed infants, however, the hyperbilirubinemia appears to be primarily the result of less effective breastfeeding. A decrease in energy intake increases the enterohepatic circulation of bilirubin, 39 which produces a greater bilirubin load on a liver that is already compromised in its ability to clear bilirubin. Because of short hospital stays after delivery, it is increasingly difficult to provide adequate advice and lactation support to mothers before they are discharged, and this support must be continued in the physician's office and at home.…”

Section: Can We Prevent Hyperbilirubinemia In Breastfed Infants?mentioning

confidence: 99%

Managing the jaundiced newborn: a persistent challenge

Maisels

2014

CMAJ

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“…26 Elevation of the non-conjugated fraction may result from various causes, including increased absorption from enterohepatic pools for reasons that are not entirely clear. 27,28 Our study shows a statistically significant increase of bilirubin among the severe alcoholics and serum bilirubin levels were best correlated with the severity of alcoholic hepatitis. Prevalence of undernutrition in alcoholics with alcoholic hepatitis due to both protein and caloric deficiency resulting from low ingestion and inadequate utilization of nutrients absorbed and in the present study we found serum albumin and total proteins level was significantly lower among the severe alcoholics.…”

Section: Discussionmentioning

confidence: 56%

Comparison of haematological parameters between alcoholics and non-alcoholics

Elanchezhian

Yoganandh

Mayilsamy³

et al. 2017

Int J Res Med Sci

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Background: Alcohol being one of the most commonly used drug, whose consequences include changes of CBC. The main causes leading to changes of CBC (complete blood count) are: myelosuppression that is accompanying with slight reduction in all blood cells, blood loss from gastrointestinal tract, malnutrition etc. Alcoholics may suffer from moderate anemia, characterized by enlarged, structurally abnormal RBC’s; mildly reduced numbers of WBC’s, especially of neutrophils; and moderately to severely reduced numbers of platelets. The objective of the study was to study the haematological manifestation among alcoholics based on the quantity and duration of alcohol intake and compare them with non-alcoholics.Methods: A cross-sectional study was conducted for a period of one year in our medical college hospital in medicine OPD with the collaboration of department of pathology and bio-chemistry. The study was started after getting the approval from the institutional ethical committee. A total of 150 study subjects were included in the study in which 50 were non-alcoholics, 50 were moderate alcoholics (less than or equal to two drinks per day for men and less than or equal to one drink per day for women) and the remaining 50 were severe alcoholics (more than 7 drinks a week in women and more than 14 drinks in a week in men). Blood investigations such as CBC, prothrombin time, liver function test, renal function test, folic acid levels and vitamin B12 levels were measured and the levels were compared between alcoholics and non-alcoholics.Results: Mean RBC count, mean MCH, MCHC were normal among the non-alcoholic group and it started decreasing among moderate alcoholics and more so with severe alcoholics and a similar type of result was also seen with total count and platelet count and the difference was found to be statistically significant. LFT, RFT, prothrombin time and vitamin B12 levels were found to be high and folate levels were decreased among alcoholics group when compared to non-alcoholics and the difference was statistically significant.Conclusions: Detection of hematological changes in chronic alcoholics and giving psychiatric counseling and treatment for alcohol dependence will decrease the future complications like cirrhosis liver, cardiac and renal disease, cerebellar degeneration, neuropathy, pancreatitis, etc. and reduce the morbidity and mortality in alcoholics.

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Effect of fasting on the uptake of bilirubin and sulfobromophthalein by the isolated perfused rat liver

Cited by 51 publications

References 3 publications

Is Breastfeeding Really Favoring Early Neonatal Jaundice?

Is Breastfeeding Really Favoring Early Neonatal Jaundice?

Managing the jaundiced newborn: a persistent challenge

Comparison of haematological parameters between alcoholics and non-alcoholics

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