Effect of fatty acids on intracellular pneumocandin B0 storage in the fermentation of Glarea lozoyensis
Weiting Zhang,
Ping Yi,
Ying Zhou
et al.
Abstract:The natural product pneumocandin B0 is the precursor of the antifungal drug caspofungin. To explore the relationship between pneumocandin B0 and oil. We found that the addition of 1 g/L of oil to the fermentation medium is more conducive to the production of pneumocandin B0. The metabolic reaction mechanism was explored using different fatty acids and the results showed that stearic acid and acetic acid increased the total production of pneumocandin B0 by 22.98% and 9.08%, respectively, as well as increasing t… Show more
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