Effect of Fe3O4 Nanoparticles Modified by Citric and Oleic Acids on the Physicochemical and Magnetic Properties of Hybrid Electrospun P(VDF-TrFE) Scaffolds

Ботвин, В. В.; Fetisova, Anastasia; Mukhortova, Yulia R.; Wagner, Dmitry V.; Казанцев, С. О.; Kholkin, A. L.; Surmenev, Roman A.

doi:10.3390/polym15143135

Cited by 8 publications

(4 citation statements)

References 57 publications

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“…The total surface energy (σ) consists of dispersive (σ d ) and polar (σ p ) components related to van der Waals interactions and hydrogen bonds, respectively, in a material. A pronounced increase in σ p from 47.2 ± 1.2 to 64.2 ± 2.0 mN/m was observed after the addition of Fe 3 O 4 –CA to the conduits (Table ), indicating possible intermolecular hydrogen bonding between polar CO groups of PHB and hydrogen atoms in free carboxyl groups of Fe 3 O 4 –CA . σ d for PHB/Fe 3 O 4 –CA is also higher as compared to PHB, implying dipolar interactions between the filler and PHB macromolecules owing to the presence of polarized carboxyl groups on the surface of Fe 3 O 4 –CA .…”

Section: Resultsmentioning

confidence: 99%

“…In addition to the presence of the Fe 3 O 4 –CA agglomerates, possible filler/polymer interactions may restrain the mobility of PHB chains, thereby diminishing the PHB/Fe 3 O 4 –CA crystallinity. The most probable interaction between Fe 3 O 4 –CA MNPs and PHB may be the intermolecular hydrogen bonding between the polar CO groups of PHB and hydrogen atoms of free carboxyl groups in CA . Moreover, the presence of these carboxyl groups on the surface of Fe 3 O 4 –CA MNPs allows for dipolar interactions between the fillers and PHB macromolecules…”

Section: Resultsmentioning

confidence: 99%

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Magnetoactive Composite Conduits Based on Poly(3-hydroxybutyrate) and Magnetite Nanoparticles for Repair of Peripheral Nerve Injury

Shlapakova,

Botvin,

Mukhortova

et al. 2024

ACS Appl. Bio Mater.

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Peripheral nerve injury poses a threat to the mobility and sensitivity of a nerve, thereby leading to permanent function loss due to the low regenerative capacity of mature neurons. To date, the most widely clinically applied approach to bridging nerve injuries is autologous nerve grafting, which faces challenges such as donor site morbidity, donor shortages, and the necessity of a second surgery. An effective therapeutic strategy is urgently needed worldwide to overcome the current limitations. Herein, a magnetic nerve guidance conduit (NGC) based on biocompatible biodegradable poly(3-hydroxybutyrate) (PHB) and 8 wt % of magnetite nanoparticles modified by citric acid (Fe 3 O 4 − CA) was fabricated by electrospinning. The crystalline structure of NGCs was studied by X-ray diffraction, which indicated an enlarged β-phase of PHB in the composite conduit compared to a pure PHB conduit. Tensile tests revealed greater ductility of PHB/ Fe 3 O 4 −CA: the composite conduit has Young's modulus of 221 ± 52 MPa and an elongation at break of 28.6 ± 2.9%, comparable to clinical materials. Saturation magnetization (σ s ) of Fe 3 O 4 −CA and PHB/Fe 3 O 4 −CA is 61.88 ± 0.29 and 7.44 ± 0.07 emu/g, respectively. The water contact angle of the PHB/Fe 3 O 4 −CA conduit is lower as compared to pure PHB, while surface free energy (σ) is significantly higher, which was attributed to higher surface roughness and an amorphous phase as well as possible PHB/ Fe 3 O 4 −CA interface interactions. In vitro, the conduits supported the proliferation of rat mesenchymal stem cells (rMSCs) and SH-SY5Y cells in a low-frequency magnetic field (0.67 Hz, 68 mT). In vivo, the conduits were used to bridge damaged sciatic nerves in rats; pure PHB and composite PHB/Fe 3 O 4 −CA conduits did not cause acute inflammation and performed a barrier function, which promotes nerve regeneration. Thus, these conduits are promising as implants for the regeneration of peripheral nerves.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Magnetoactive Composite Conduits Based on Poly(3-hydroxybutyrate) and Magnetite Nanoparticles for Repair of Peripheral Nerve Injury

Shlapakova,

Botvin,

Mukhortova

et al. 2024

ACS Appl. Bio Mater.

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“…Botvin et al. [ 124 ] used magnetic fillers—magnetite (Fe 3 O 4 ) nanoparticles as fillers and modified the surface of the fillers with citric acid (CA) and oleic acid (OA) modifiers. The effect was to have both hydrophilicity and hydrophobicity, while also reducing the aggregation tendency of Fe 3 O 4 nanoparticles.…”

Section: Pvdf Flexible Piezoelectric Tactile Sensors Doped With Funct...mentioning

confidence: 99%

PVDF‐Based Flexible Piezoelectric Tactile Sensors: Review

Qi,

Xu,

et al. 2023

Cryst. Res. Technol.

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With the advent of the intelligence era, flexible piezoelectric tactile sensors are the key components for sensing information and sending signals. The performance parameters of piezoelectric sensors are closely related to the selection of piezoelectric materials. Compared with conventional piezoelectric materials, polyvinylidene fluoride (PVDF) has significant advantages in flexibility, stretchability, chemical stability, electromechanical conversion, ease of use, and acoustic propagation impedance. As a result, PVDF has become a popular topic of research. This paper introduces the working principle of piezoelectric materials and flexible piezoelectric sensors based on PVDF materials and details the research progress of different materials based on PVDF for the preparation of flexible piezoelectric tactile sensors, such as: PVDF and its copolymers for the preparation of flexible piezoelectric sensors and PVDF doped with other functional materials for the preparation of flexible piezoelectric sensors. In this paper, the advantages and disadvantages of different materials and the development prospects of PVDF flexible piezoelectric sensors are summarized to provide some insights for high‐performance flexible PVDF piezoelectric sensors.

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“…Currently, the development of magnetic nanomaterials is receiving increased research attention related to the combination in the composition and the appearance of new unique physico-chemical properties in the system that allow them to be used as magnetically active materials [ 13 , 14 , 15 ]. One of the ways to obtain the magnetic characteristics of nanostructures may be to modify the surface of the obtained magnetic polymer materials.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Modification of a Natural Polymer with the Participation of Metal Nanoparticles, Study of Their Composition and Properties

Zhakina,

Rakhimova,

Vassilets

et al. 2024

Polymers

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A magnetic polymer material based on natural polymers—humic acids and magnetite, pre-configured for the sorption of a metal ion—was obtained. The magnetic polymer material was obtained via the interaction of a natural polymer, magnetite nanoparticles and sorbed metal ions that were used as a template. Moreover, the formation of a pre-polymerization complex was followed by copolycondensation with an amine in the presence of a crosslinking agent and further removal of metal ions from the crosslinked copolymer. The physicochemical properties of the resulting materials were determined using various physical methods. The composition of the resulting magnetic polymer materials was characterized by elemental analysis using an Elementar Unicube elemental analyzer. It was found that the carbon content increases by 8.28% and nitrogen by 0.42% for the polymer material Fe3O4:HA:T:AA; for the polymer material Fe3O4:HA:AA, the carbon content increases by 14.61% and nitrogen by 3.01%. Based on the IR spectra data, it is clear that magnetic polymer materials have much in common before hydrolysis (Fe3O4:HA:T:AA) and after hydrolysis (Fe3O4:HA:AA). The structure of the resulting polymer materials was studied using electron microscopy. Micrographs show the presence of pores in magnetic polymer materials after acid hydrolysis, indicating the formation of imprints. The results of the study of the sorption properties of magnetic polymer materials showed that after acid hydrolysis, the sorption capacity of a customized magnetic polymer material increases two times and it can act as a magnetic sorption material.

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Effect of Fe3O4 Nanoparticles Modified by Citric and Oleic Acids on the Physicochemical and Magnetic Properties of Hybrid Electrospun P(VDF-TrFE) Scaffolds

Cited by 8 publications

References 57 publications

Magnetoactive Composite Conduits Based on Poly(3-hydroxybutyrate) and Magnetite Nanoparticles for Repair of Peripheral Nerve Injury

Magnetoactive Composite Conduits Based on Poly(3-hydroxybutyrate) and Magnetite Nanoparticles for Repair of Peripheral Nerve Injury

PVDF‐Based Flexible Piezoelectric Tactile Sensors: Review

Synthesis and Modification of a Natural Polymer with the Participation of Metal Nanoparticles, Study of Their Composition and Properties

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