2021
DOI: 10.1080/21655979.2021.1874693
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Effect of fed-batch and chemostat cultivation processes of C. glutamicum CP for L-leucine production

Abstract: Most of the current industrial processes for L-leucine production are based on fermentation, usually in fed-batch operation mode. Although the culture technology has advanced in recent decades, the process still has significant drawbacks. To solve these problems, we investigated the effects of chemostat culture conditions on the production of L-leucine by Corynebacterium glutamicum CP. The dilution rate, the nitrogen source, and the carbon-nitrogen ratio of the medium were optimized. With the addition of ammon… Show more

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Cited by 7 publications
(1 citation statement)
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“…Compared to batch and fed-batch modes, the chemostat method has some advantages. In the laboratory, chemostat cultures can be used to determine microbial growth rates and amounts of nutrients consumed and metabolites produced, as well as to allow the selection of strains with specific phenotypic functions (Hsu et al, 1977;Rajaraman et al, 2016;Zhang et al, 2021). Despite this, none of the articles described in this review used this method (Table 1).…”
Section: Adaptive Laboratory Evolution Methodologiesmentioning
confidence: 99%
“…Compared to batch and fed-batch modes, the chemostat method has some advantages. In the laboratory, chemostat cultures can be used to determine microbial growth rates and amounts of nutrients consumed and metabolites produced, as well as to allow the selection of strains with specific phenotypic functions (Hsu et al, 1977;Rajaraman et al, 2016;Zhang et al, 2021). Despite this, none of the articles described in this review used this method (Table 1).…”
Section: Adaptive Laboratory Evolution Methodologiesmentioning
confidence: 99%