Effect of feeding an immune modulator to multiparous Holstein cows during the dry period and early lactation on health, milk and reproductive performance

Casarotto, L.T.; Laporta, Jimena; Ferreira, Kamila Daniele de Resende; Davidson, B.D.; Moy, K.; Almeida, A. K.; Chapman, J. D.; McLean, D. J.; Kirk, D.; Barbu, N; Ouellet, V.; Dahl, Geoffrey E.

doi:10.1016/j.anifeedsci.2020.114527

Cited by 5 publications

(3 citation statements)

References 28 publications

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“…The current experiment showed that the concentrations of IgA in the H and M groups were significantly higher than that in the L group. A previous study indicated that feeding an immunomodulatory supplement from dry‐off until 150 days in milk improved the milk yield and reduced the incidence of diseases (Casarotto et al., 2020 ). Thus, we speculate that dairy cows with higher milk yields have superior IgA response that may let them combat some disease more effectively and thus support great milk production.…”

Section: Discussionmentioning

confidence: 99%

The physiological dissimilarities of Holstein dairy cows with different milk yields

Dong

Liu

et al. 2022

Veterinary Medicine & Sci

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Background Even if breed, parity, dietary and environmental management are same, dairy cows still have notable differences in milk yield that may be underpinned by physiologic differences. Objectives This study aimed to investigate the physiological dissimilarities of dairy cows with different milk yields. Methods Thirty cows were sorted into high milk‐yielding cows (group H: 58.93±2.31 kg/day), moderate milk‐yielding cows (group M: 44.99±0.54 kg/day), and low milk‐yielding cows (group L: 24.99±6.83 kg/day) according to milk yield. Blood was collected and serum parameters were assessed. Rumen fluid was collected for the evaluation of rumen fermentation parameters (RFPs) and bacterial community composition (BCC). Results Serum prolactin, growth hormone, glutathione peroxidase, immunoglobulin A and non‐esterified fatty acid had a significantly positive correlation with milk yield ( p < 0.05), whereas serum glucagon and total antioxidant capacity had a significantly negative correlation with milk yield ( p < 0.05). The concentration of valeric acid and the ratio of acetic acid to propionic acid in the rumen fluid in group H was significantly lower than that in group L ( p < 0.05). The concentration of acetic acid and butyric acid in group H was significantly lower than that in groups M and L ( p < 0.05). The relative abundances of Ruminococcaceae_NK4A214 _group, Prevotella_1 , Rikenellaceae_RC9_gut_group , Christensenellaceae_R‐7_group , Muribaculaceae , and Ruminococcus_2 were negatively correlated with milk yield, whereas the relative abundance of Succinivibrionaceae_UCG‐001 , Lachnospiraceae_NK3A20_group, Shuttleworthia and Dialister were positively correlated with milk yield ( p < 0.05). Conclusions This study indicates that dairy cows with different milk yields have clear divergence in serum indicators, RFPs, BCC and rumen microbial metabolism.

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Section: Discussionmentioning

confidence: 99%

The physiological dissimilarities of Holstein dairy cows with different milk yields

Dong

Liu

et al. 2022

Veterinary Medicine & Sci

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“…OG feeding can also influence metabolic pathways and maintain overall animal health [19] [20]. Despite the close link between immune function, metabolism and reproductive function, evaluating the effects of OG supplementation on reproductive performance have focused on production measurements in dairy cows [21]. We have demonstrated that feeding OG Open Journal of Animal Sciences to cows during a superovulation protocol resulted in decreased percentage of degenerate embryos at the time of collection [22].…”

Section: Introductionmentioning

confidence: 99%

Measurement of Metabolic and Inflammatory Serum Markers and Immune Marker Gene Expression during Superovulation in Beef Cattle

Snider¹,

McLean²,

Menino³

2021

OJAS

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Health status of donor cows during superovulation is important to ensure optimal embryo quality at time of collection. Because nutritional and metabolic status impact embryo quality some form of nutritional supplementation is often provided before and during superovulation. OmniGen-AF® (OG) feeding has been shown to assist in the maintenance of animal health through regulation of metabolic status and balance and supporting aspects of immune function. We observed feeding donor cows OG decreased percent degenerate embryos recovered following superovulation increased serum progesterone concentration and improved in vitro embryo development. Evaluation of OG feeding on markers of metabolic function and inflammatory and immune function in beef cattle embryo donors are reported here. Similarly, cow metabolic and inflammatory response with repeated superovulation protocols is not known. Biomarkers to monitor and evaluate cow health during superovulation may provide management options to improve embryo recovery and quality. Twenty-four Angus cross-bred cattle were randomly assigned to four treatment groups, fed 0 or 56 g/hd/day for 49 days and superovulated with 200 or 400 mg Folltropin V (FSH). Blood was collected weekly for analyses. The protocol was repeated on all cows 90 -120 d later with cows reassigned to their original groups. No differences (P > 0.10) were observed due to OG feeding or FSH dose on metabolic and inflammatory markers. Replicate exerted a significant effect where serum concentration of albumin, IL1β, IL6, PGE 2 and leptin were lower (P < 0.05) in Replicate 1 compared to 2. There was also a similar pattern of change in several of the metabolic and

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“…Feeding OG has also been shown to support immune system regulation during exposure to stressors [10] [11]. Dairy producers have reported a benefit in reproductive performance with the addition of OG into their herds [12] and incorporating OG into the ration of dairy cows has shown to reduce the number of days open [13]. Recently, our laboratory reported feeding OG to beef cow donors provided the beneficial effects of more transferrable embryos, fewer percent degenerate embryos and increased plasma progesterone on the day of embryo recovery [14].…”

Section: Introductionmentioning

confidence: 99%

Effects of Feeding OmniGen-AF<sup>&reg</sup> during Superovulation on <i>in Vitro</i> Development of Embryos Recovered from Donor Beef Cows

Snider¹,

McLean²,

Menino³

2021

OJAS

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Embryo quality is crucial when selecting embryos for transfer. Variation in quality may be attributed to poor oocytes, semen, stress, inflammation, and potential immune system dysregulation. OmniGen-AF ® (OG) feeding supports immune system function and animal health. Our laboratory recently reported lower percent degenerate embryos recovered and increased plasma progesterone in beef cattle donors fed OG during superovulation. In vitro development of embryos recovered from donor cows fed OG prior to collection is presented here. Embryos were recovered from 24 beef cows assigned to four treatment groups: 0 g OG/hd/d and 200 mg Folltropin ® -V (FSH) (0/200); 0 g OG/hd/d and 400 mg FSH (0/400), 56 g OG/hd/d, 200 mg FSH (56/200) and 56 g OG/hd/d and 400 mg FSH (56/400). Good to excellent quality early blastocysts were cultured for 8 d. and development through hatching, embryonic volume and plasminogen activator (PA) production were quantified. The complete protocol was repeated 90 -120 d later as Replicate 2. Optimal development was observed by embryos recovered from 0/200 cows where percent blastocysts hatching was greater (P < 0.05) compared to 56/200 and 0/400 cows and embryonic volume was greatest (P < 0.05) in Replicate 1. However, percent blastocysts hatching from 0/200 cows was similar (P > 0.10) to 56/400 cows and embryos recovered from 56/400 cows in Replicate 1 produced more (P < 0.05) PA compared to all other groups. For cows superovulated with the standard 400-mg FSH dose, feeding OG supported in vitro embryo development similar to that observed for 0/200 cows.

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Effect of feeding an immune modulator to multiparous Holstein cows during the dry period and early lactation on health, milk and reproductive performance

Cited by 5 publications

References 28 publications

The physiological dissimilarities of Holstein dairy cows with different milk yields

The physiological dissimilarities of Holstein dairy cows with different milk yields

Measurement of Metabolic and Inflammatory Serum Markers and Immune Marker Gene Expression during Superovulation in Beef Cattle

Effects of Feeding OmniGen-AF<sup>&reg</sup> during Superovulation on <i>in Vitro</i> Development of Embryos Recovered from Donor Beef Cows

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Effect of feeding an immune modulator to multiparous Holstein cows during the dry period and early lactation on health, milk and reproductive performance

Cited by 5 publications

References 28 publications

The physiological dissimilarities of Holstein dairy cows with different milk yields

The physiological dissimilarities of Holstein dairy cows with different milk yields

Measurement of Metabolic and Inflammatory Serum Markers and Immune Marker Gene Expression during Superovulation in Beef Cattle

Effects of Feeding OmniGen-AF&lt;sup&gt;&amp;reg&lt;/sup&gt; during Superovulation on &lt;i&gt;in Vitro&lt;/i&gt; Development of Embryos Recovered from Donor Beef Cows

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Effects of Feeding OmniGen-AF<sup>&reg</sup> during Superovulation on <i>in Vitro</i> Development of Embryos Recovered from Donor Beef Cows