Effect of feeding regimen on circadian activity rhythms of food anticipatory by ghrelin hormone in a pig model

Zhang, He; Yan, Xiaoxi; Lin, Ailian; Xia, Pengke; Jia, Menglan; Su, Yong

doi:10.1080/1028415x.2022.2047436

Cited by 3 publications

(2 citation statements)

References 56 publications

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“…Our previous research found that, after feeding at 7:00 a.m., they presented feeding behaviors until 5:00 p.m. In addition, there are no regular changes in pig feeding behavior and serum ghrelin levels [ 38 ]. People’s normal eating times are 7:00, 12:00 and 17:00.…”

Section: Discussionmentioning

confidence: 99%

Antagonization of Ghrelin Suppresses Muscle Protein Deposition by Altering Gut Microbiota and Serum Amino Acid Composition in a Pig Model

Yan

Zhang

Lin

et al. 2022

Biology

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Ghrelin is an appetite-stimulating hormone that can increase food intake and has been reported to prevent muscle loss; however, the mechanism is not yet fully understood. In this study, [D-Lys3]-GHRP-6 (GHRP) was used to investigate the effects of the antagonization of ghrelin on muscle protein deposition, eating patterns and gut microbiota in a pig model. We found that the growth performance and muscle fiber cross-sectional area of pigs treated with GHRP were significantly reduced compared with the control (CON) group. Moreover, the levels of serum isoleucine, methionine, arginine and tyrosine in the GHRP group were lower than that of the CON group. The abundance of acetate-producing bacteria (Oscillospiraceae UCG-005, Parabacteroides and Oscillospiraceae NK4A214 group) and acetate concentration in the colons of pigs treated with GHRP were significantly reduced. In addition, the injection of GHRP down-regulated the mRNA expression of MCT-1 and mTOR, and it up-regulated the mRNA expression of HDAC1, FOXO1 and Beclin-1. In summary, the antagonization of ghrelin reduced the concentration of important signal molecules (Arg, Met and Ile) that activate the mTOR pathway, concurrently reduce the concentration of HDAC inhibitors (acetate), promote autophagy and finally reduce protein deposition in muscles.

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Section: Discussionmentioning

confidence: 99%

Antagonization of Ghrelin Suppresses Muscle Protein Deposition by Altering Gut Microbiota and Serum Amino Acid Composition in a Pig Model

Yan

Zhang

Lin

et al. 2022

Biology

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“…Studies have demonstrated that fish align their activity periods with mealtimes; however, the presence of a FEO in fish that is separate and independent from the LEO is still an open question. Some unconventional mammalian systems have also been utilized; a recent study employed a pig model to show that ghrelin antagonist administration lowered FAA ( 17 ). While the bulk of research in the field has been conducted on rats and mice, alternative rodent models like Syrian hamsters ( M. auratus ), gerbils ( M. unguiculatus ), and the diurnal rodent A. ansorgei have been helpful in demonstrating the widespread nature of FAA and testing variables such as age and photoperiod ( 18 , 19 ).…”

Section: Model Systems Used To Study Food Entrainmentmentioning

confidence: 99%

Studying food entrainment: Models, methods, and musings

Trzeciak¹,

Steele²

2022

Front. Nutr.

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The ability to tell time relative to predictable feeding opportunities has a long history of research, going back more than 100 years with behavioral observations of honeybees and rats. Animals that have access to food at a particular time of day exhibit “food anticipatory activity” (FAA), which is a preprandial increase in activity and arousal thought to be driven by food entrained circadian oscillator(s). However, the mechanisms behind adaptation of behavior to timed feeding continue to elude our grasp. Methods used to study circadian entrainment by food vary depending on the model system and the laboratory conducting the experiments. Most studies have relied on rodent model systems due to neuroanatomical tools and genetic tractability, but even among studies of laboratory mice, methods vary considerably. A lack of consistency within the field in experimental design, reporting, and definition of food entrainment, or even FAA, makes it difficult to compare results across studies or even within the same mutant mouse strain, hindering interpretation of replication studies. Here we examine the conditions used to study food as a time cue and make recommendations for study design and reporting.

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Decreasing light exposure increases the abundance of antibiotic resistance genes in the cecum and feces of laying hens

Zhang,

Chen,

Yuan

et al. 2024

Science of The Total Environment

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Effect of feeding regimen on circadian activity rhythms of food anticipatory by ghrelin hormone in a pig model

Cited by 3 publications

References 56 publications

Antagonization of Ghrelin Suppresses Muscle Protein Deposition by Altering Gut Microbiota and Serum Amino Acid Composition in a Pig Model

Antagonization of Ghrelin Suppresses Muscle Protein Deposition by Altering Gut Microbiota and Serum Amino Acid Composition in a Pig Model

Studying food entrainment: Models, methods, and musings

Decreasing light exposure increases the abundance of antibiotic resistance genes in the cecum and feces of laying hens

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