Effect of feeding various dietary vitamin B<sub>6</sub>concentrations during gestation and lactation on vitamin B<sub>6</sub>level in liver and carcass of rat dams

Roth‐Maier, Dora A.; Benedikt, Jan; Stangl, Gabriele I.; Kirchgeßner, M.

doi:10.1080/17450399609381894

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…For thiamin, it has been demonstrated that a high supply during pregnancy increases thiamin storage in the body, and therefore the thiamin supply during pregnancy markedly influences both the thiamin status during lactation and the thiamin concentrations in the milk (R oth ‐M aier et al 1990; K irchgessner et al 1997). In contrast, for vitamin B 6 it has been shown that a high supply during pregnancy does not produce additional storage (R eithmayer et al 1985), and therefore vitamin B 6 supply during pregnancy only had a slight influence on the vitamin B 6 status during lactation (R oth ‐M aier et al 1996; B enedikt et al 1996). In order to investigate the physiological behaviour of riboflavin in this respect, rats were fed diets with various supplementary levels of riboflavin during pregnancy and lactation and the concentrations of riboflavin were determined in the liver and carcass after pregnancy and lactation and in the milk of lactating rats.…”

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confidence: 99%

The effect of dietary riboflavin supplementation during pregnancy and lactation on riboflavin concentrations of milk, liver and carcass of lactating rats

Kirchgeßner

Hirschvogl

Eder

et al. 1997

Animal Physiology Nutrition

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Summary The aim of the present study was to investigate the effect of riboflavin supply during pregnancy and lactation on the riboflavin status of rats after pregnancy and lactation. Therefore, an experiment with a total of 81 female rats was conducted. The effect of riboflavin supplementation during pregnancy on riboflavin status after pregnancy was investigated by feeding diets with various riboflavin supplements (1, 5 or 20 mg riboflavin per kg diet) and the determination of riboflavin concentrations in liver and carcass (bled whole body without intestine and liver). The study shows a marked influence of dietary riboflavin supplementation during pregnancy on riboflavin concentrations of liver and body after pregnancy. Liver exhibited maximum riboflavin concentrations at a supplementary level of 5 mg/kg diet whereas riboflavin concentrations in the carcass were raised by increasing the supplementary level from 5 to 20 mg/kg diet. The riboflavin status after lactation has been studied in response to the riboflavin supplementation during pregnancy (1 or 20 mg/kg diet) and lactation (1, 5 and 20 mg/kg diet). In order to assess the riboflavin status, riboflavin concentrations in the liver and carcass (at the 14th day of lactation) and milk (7th and 13th day of lactation) were determined. The study shows that the riboflavin concentrations of all the samples are influenced predominately by the riboflavin supply during lactation; the riboflavin supply during pregnancy had only a slight effect on the riboflavin concentrations of milk, liver and carcass. Moreover, the riboflavin concentration in milk was more influenced by the riboflavin supply during lactation than the riboflavin concentrations of the liver and carcass. Increasing the riboflavin supplementation during lactation from 1 to 20 mg/kg diet caused a five‐fold increase of riboflavin concentrations in milk, whereas riboflavin concentrations in the liver and carcass increased only by ≅ 80%. Those results demonstrate that the riboflavin concentration in milk can be varied over a wide range by the riboflavin supply during lactation whereas the riboflavin concentrations of tissues are under homeostatic control. Moreover, the study shows that a high riboflavin supply during pregnancy cannot compensate for a deficient supply during lactation. Therefore, particular attention has to be given to the dietary riboflavin supply during both physiological states. Zusammenfassung Zum Einfluß der Riboflavinversorgung während Gravidität und Laktation auf die Riboflavinkon‐zentrationen von Milch, Leber und Restkörper laktierender Ratten Die vorliegende Arbeit hatte zum Ziel, den Einfluß unterschiedlicher Riboflavinzulagen der Diät während Gravidität und Laktation auf den Riboflavinstatus nach Gravidität und Laktation zu untersuchen. Dazu wurde ein Versuch mit insgesamt 81 weiblichen Ratten durchgeführt. Der Einfluß der Riboflavinversorgung auf den Riboflavinstatus nach der Gravidität wurde untersucht, indem während der Gravidität ein Futter mit unterschiedlichen Riboflavinzulag...

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Section: Introductionmentioning

confidence: 99%

The effect of dietary riboflavin supplementation during pregnancy and lactation on riboflavin concentrations of milk, liver and carcass of lactating rats

Kirchgeßner

Hirschvogl

Eder

et al. 1997

Animal Physiology Nutrition

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Dietary thiamin supply during lactation influences thiamin status in lactating rats and their offspring and the thiamin level in milk

et al. 1997

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This study was conducted to examine the effect of dietary thiamin, ranging from deficient to excessive supplies, on thiamin status of lactating rats and their offspring, and the thiamin level in milk. Therefore, after parturition, rat dams were divided into eight groups of 10 each, and were fed diets with 0, 2, 4, 6, 7, 40, 350 and 3500 mg/kg thiamin over a total of 13 days during lactation. Milk for determining the thiamin concentration was obtained from day 6 and 13 of lactation. At day 14 of lactation rat dams and their offspring were used to ascertain the thiamin status including transketolase activity of blood, liver and brain, and thiamin concentration in body. Thiamin supplies ranging from deficient to excessive dietary concentrations influenced both the thiamin levels of the lactating dams and their offspring within 13 days. Lactating rat dams fed a thiamin-free diet and their offspring were classified as thiamin-deficient on the basis of growth retardation and a lower activity of transketolase in blood, liver and brain. Within these variables transketolase in blood has been shown to be most sensitive, and reached a plateau feeding 6 mg/kg thiamin. The concentration of thiamin in milk ranged between 0.1 and 19 mg/kg. The findings also show that dietary thiamin had the strongest effect on thiamin in milk obtained from day 6 and 13 of lactation, and a deficient or suboptimal supply with thiamin was therefore not compensated for an intensified transfer of reserved body thiamin into milk. Also thiamin levels in tissues and carcass, which did not show any clear-cut saturation characteristic, increased with increasing dietary thiamin, and this dose-dependence was more marked in blood and liver than in carcass.

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Nutritional requirements of lactating women

Coutts

1998

British Journal of Midwifery

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The benefits of breastfeeding, as opposed to formula feeding for the baby are well known, and it is widely understood that the mother is also likely to gain from breastfeeding (Mepham, 1987). Lactation offers some protection from breast cancer and will assist her in regaining her pre-pregnancy figure and weight. Much less is known, however, about the nutritional needs of the mother — the only advice she is likely to receive is to: ‘eat a well-balanced diet and drink plenty.’ This article seeks to review the literature into what lactating women require.

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Effect of feeding various dietary vitamin B₆concentrations during gestation and lactation on vitamin B₆level in liver and carcass of rat dams

Cited by 3 publications

References 13 publications

The effect of dietary riboflavin supplementation during pregnancy and lactation on riboflavin concentrations of milk, liver and carcass of lactating rats

The effect of dietary riboflavin supplementation during pregnancy and lactation on riboflavin concentrations of milk, liver and carcass of lactating rats

Dietary thiamin supply during lactation influences thiamin status in lactating rats and their offspring and the thiamin level in milk

Nutritional requirements of lactating women

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Effect of feeding various dietary vitamin B6concentrations during gestation and lactation on vitamin B6level in liver and carcass of rat dams

Cited by 3 publications

References 13 publications

The effect of dietary riboflavin supplementation during pregnancy and lactation on riboflavin concentrations of milk, liver and carcass of lactating rats

The effect of dietary riboflavin supplementation during pregnancy and lactation on riboflavin concentrations of milk, liver and carcass of lactating rats

Dietary thiamin supply during lactation influences thiamin status in lactating rats and their offspring and the thiamin level in milk

Nutritional requirements of lactating women

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Effect of feeding various dietary vitamin B₆concentrations during gestation and lactation on vitamin B₆level in liver and carcass of rat dams