Effect of felodipine with irbesartan or metoprolol on sexual function and oxidative stress in women with essential hypertension

Ma, Rong; Yu, Jing; Xu, Dakang; Yang, Longquan; Lin, Xin; Zhao, Feng; Feng, Bo

doi:10.1097/hjh.0b013e32834e1e2e

Cited by 35 publications

(37 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This distinction may also explain the lack of a difference between these two combination therapies on some items of the IIEF and the prevalence of ED. Similar results were observed in another study on female hypertensive patients in which felodipine-metoprolol had no influence on the total score of the female sexual function index [33]. …”

Section: Discussionsupporting

confidence: 88%

The Effect of Combined Antihypertensive Treatment (Felodipine with Either Irbesartan or Metoprolol) on Erectile Function: A Randomized Controlled Trial

Yang

Yu²,

Ma³

et al. 2013

Cardiology

Self Cite

View full text Add to dashboard Cite

Objectives: This study aimed to determine whether combining a calcium channel blocker with either an angiotensin II receptor blocker or a β-blocker would have similar effects on sexual function in men with hypertension. Methods: This prospective, randomized study (ClinicalTrials.gov: NCT01238705) included 218 male participants with untreated hypertension. Patients were randomized to treatment with felodipine combined with irbesartan or metoprolol for 48 weeks. Sexual function was evaluated at baseline and after 48 weeks of therapy. The levels of serum sex hormones and markers of oxidative stress were measured at the same time. Results: There was no significant difference in the prevalence of erectile dysfunction before and after treatment in either group (p > 0.05). There were also no differences in the levels of serum testosterone, sex hormone-binding globulin or 4-hydroxynonenal before and after treatment in either group (p > 0.05). In the felodipine-irbesartan group, sexual desire scores rose after treatment (p = 0.022) and the concentrations of serum 8-hydroxy-2′-deoxyguanosine and malondialdehyde declined (p < 0.001 and p = 0.002, respectively). The between-group differences for 8-hydroxy-2′-deoxyguanosine and malondialdehyde were not significant (p > 0.05, respectively). Conclusion: The results suggest that felodipine-irbesartan may be more beneficial to the sexual desire of hypertensive male patients than felodipine-metoprolol. This effect was possibly relevant to irbesartan, which prevents oxidative stress to some extent.

show abstract

Section: Discussionsupporting

confidence: 88%

The Effect of Combined Antihypertensive Treatment (Felodipine with Either Irbesartan or Metoprolol) on Erectile Function: A Randomized Controlled Trial

Yang

Yu²,

Ma³

et al. 2013

Cardiology

Self Cite

View full text Add to dashboard Cite

show abstract

“…83,84 Levels of aldehydes, such as MDA-LDL and 4-hydroxy-2-nonenal (4-HNE), have been proposed as a biological signature of clinical in vivo LDL oxidation. [85][86][87][88][89] Mutlu-Turkoglu et al 87 reported that plasma MDA levels were increased in elderly subjects compared with those in young subjects. Lovell et al 89 have shown that ventricular fluid levels of 4-HNE are significantly higher in patients with Alzheimer's disease, an agerelated disease, than in control subjects.…”

Section: Tetrahydrobiopterin (Bh 4 )mentioning

confidence: 99%

Endothelial dysfunction and hypertension in aging

2012

View full text Add to dashboard Cite

Hypertension is one of the common diseases in the elderly. The prevalence of hypertension markedly increases with advancing age. Both aging and hypertension have a critical role in cardiovascular and cerebrovascular complications. Although aging and hypertension, either independently or collectively, impair endothelial function, aging and hypertension may have similar cascades for the pathogenesis and development of endothelial dysfunction. Nitric oxide (NO) has an important role in regulation of vascular tone. Decrease in NO bioavailability by endothelial dysfunction would lead to elevation of blood pressure. An imbalance of reduced production of NO or increased production of reactive oxygen species, mainly superoxide, may promote endothelial dysfunction. One possible mechanism by which the prevalence of hypertension is increased in relation to aging may be advancing endothelial dysfunction associated with aging through an increase in oxidative stress. In addition, endothelial cell senescence is also involved in aging-related endothelial dysfunction. In this review, we focus on recent findings and interactions between endothelial function, oxidative stress and hypertension in aging.

show abstract

“…Больным АГ можно безопасно назначать ингибиторы фосфодиэстеразы-5, даже тем из них, которые получают несколько антигипертензивных препаратов (за исключением альфа-блокаторов и нитратов) [594], причем это может улучшить при-верженность антигипертензивной терапии [595]. Исследования по влиянию АГ и антигипертензивной терапии на половую функцию женщин находятся в самом начале и должны всячески поощряться [596].…”

Section: половая дисфункцияunclassified

2013 Esh/Esc Guidelines for the Management of Arterial Hypertension

Mancia

Fagard²,

Redón³

et al. 2014

Russ J Cardiol

View full text Add to dashboard Cite

Авторы/члены рабочей группы: Giuseppe Mancia (сопредседатель; италия)*, Robert Fagard (сопредседатель; бельгия)*, Krzysztof Narkiewicz (координатор секции, Польша), Josep Redón (координатор секции; испания), Alberto Zanchetti (координатор секции, италия), Michael Böhm

show abstract

Effect of felodipine with irbesartan or metoprolol on sexual function and oxidative stress in women with essential hypertension

Cited by 35 publications

References 35 publications

The Effect of Combined Antihypertensive Treatment (Felodipine with Either Irbesartan or Metoprolol) on Erectile Function: A Randomized Controlled Trial

The Effect of Combined Antihypertensive Treatment (Felodipine with Either Irbesartan or Metoprolol) on Erectile Function: A Randomized Controlled Trial

Endothelial dysfunction and hypertension in aging

2013 Esh/Esc Guidelines for the Management of Arterial Hypertension

Contact Info

Product

Resources

About