Effect of Female Body Mass Index on Clinical Pregnancy Rate After In Vitro Fertilization

Association between maternal prepregnancy body mass index and pregnancy outcomes following assisted reproductive technology: A systematic review and dose–response meta‐analysis

“…In the final analysis, 105 eligible studies (19 prospective and 86 retrospective cohort studies) were included, involving more than 271,632 pregnant women (Figure 1). 14,15,28–130 The main characteristics of included studies were summarized in Table S1. In total, 100 studies reported the association between maternal BMI and CPR among pregnant women undergoing ART, among which 53 reported MR and 51 reported LBR (Table S1).…”

“…In total, 100 studies reported the association between maternal prepregnancy body weight and CPR after ART 14,15,28–55,58–80,82–117,119–122,124–130 . At per‐woman level, 54 studies, involving 109,688 pregnant women, showed an inverted J‐shaped relationship between maternal BMI and CPR ( P n < 0.01) 14,28–31,34–36,40,41,44,46,47,49,53,58,60,61,64–68,75,76,78,82,85,86,88–95,97,99,103–106,109,112–114,119,121,124,126–128,130 . Compared with the reference BMI value (21.75 kg/m 2 ), BMI > 22.5 kg/m 2 was associated with lower CPR (Figure 2a and Table 1).…”

“…14,15,28-55,58-80, 82-117,119-122,124-130 At per-woman level, 54 studies, involving 109,688 pregnant women, showed an inverted J-shaped relationship between maternal BMI and CPR (P n < 0.01). 14,[28][29][30][31][34][35][36]40,41,44,46,47,49 2a and Table 1). By combining adjusted estimates from five studies involving 62,765 pregnant women, 14,89,99,126,130 the adjusted OR for each 5-unit increase in BMI was 0.96 (95% CI: 0.94-0.98, I 2 = 0.0%, P n = 0.07).…”