Effect of fenoprofen on thyroid function tests

Tillman, Janet; Leask, J.T.S.; Campbell, John C.; Logue, F. C.; Fraser, William D.

doi:10.1016/0009-8981(86)90216-0

Cited by 4 publications

(2 citation statements)

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“…However, the new Vitros FT3 kit did not detect FT3 in the diclofenac-free medium. The NSAID, fenoprofen, has been previously reported to cause a false elevation in T3 and FT3 levels via a cross-reaction mechanism [13]. Our results suggest that a cross-reaction is the main cause of the false elevation in FT3 levels assayed by Vitros FT3 kit in case 1.…”

Section: Discussionmentioning

confidence: 57%

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Cross-Reactive Mechanism for the False Elevation of Free Triiodothyronine in the Patients Treated with Diclofenac.

Kasono¹,

Hikino²,

Fujino³

et al. 2001

Endocr J

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Abstract.We report three cases of patients exhibiting a false elevation of serum free triiodothyronine (FT3) as a result of a cross-reaction with diclofenac.The first case is a 66-yr-old woman with a long history of rheumatoid arthritis (RA). The patient was receiving diclofenac for the treatment of her RA. The patient was subsequently diagnosed as having thyroid papillary adenocarcinoma and received a subtotal thyroidectomy.After the operation, the patient exhibited postoperative hypothyroidism except for a gradual elevation of FT3. The other two patients also exhibited an elevated serum FT3 level after the administration of diclofenac.Serum FT3 levels in these patients decreased to normal or below normal after diclofenac administration was discontinued.In the first case, the elimination of immunoglobulin from the sera using polyethylene glycol precipitation did not reduce the FT3 level. In our hospital, Vitros ECi (enhanced chemiluminescence enzyme immunoassay) system and Vitros FT3 kit were used for FT3 assay. The patient's FT3 levels were normal or below normal when they were measured using other FT3 kits. FT3 was also detected when diclofenac was dissolved in a phosphate buffered saline. Therefore, we concluded that a cross-reaction between FT3 and diclofenac was the mechanism causing the false elevation of FT3 in these patients.

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Section: Discussionmentioning

confidence: 57%

“…Cross-reactions with administered drugs [13] or serum proteins [14J are a common cause of falsely elevated hormone concentrations.…”

Section: Introductionmentioning

confidence: 99%