Effect of fentanyl on the circulatory responses to orotracheal fibreoptic intubation

Smith, J. E.; King, M. J.; Yanny, H.F.; Pottinger, K. A.; Pomirska, M. B.

doi:10.1111/j.1365-2044.1992.tb01946.x

Cited by 22 publications

(11 citation statements)

References 13 publications

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“…Few studies have shown that Fentanyl, 15,16,17 or Nalbuphine 18,19 are effective in blunting pressor response anaesthetic agents to laryngoscopy and endotracheal intubation.…”

Section: Resultsmentioning

confidence: 99%

Attenuation of Haemodynamic Response to Endotracheal Intubation With Nalbuphine and Fentanyl: A Comparative Study

Bhandari¹,

Rastogi²,

Tyagi³

et al. 2015

jemds

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BACKGROUND:Endotracheal intubation is a most noxious stimuli in anaesthesia in form of tachycardia and hypertension. Many drugs have been tried to attenuate these adverse hemodynamic responses, but no ideal drug has been discovered. We compare the effect of fentanyl and nalbuphine on modifying the hemodynamic response to laryngoscopy and tracheal intubation. METHODS: Two randomly assigned groups of 40 patient each, aged 20-60 years, were scheduled for elective surgery receive Group 1 inj Fentanyl 2ug/kg or GROUP 2 inj Nalbuphine 0.2mg/kg iv 5min before laryngoscopy and intubation. Haemodynamic parameters and post-operative complications were recorded. RESULTS: Immediately after drug administration, the heart rate (HR) in group I decreased from basal value of 85.55±10.85bpm to 83.75±14.11bpm, in group II increased from basal value of 89.83±1.48bpm to 95.33±16.99bpm (p<0.05). The decrease in mean SBP was in both the groups, but more in group II. Immediately after drug administration decrease in DBP was in both the groups, which was more in group I than group II (p<0.05) it persisted in group II at 15 and 30 min after intubation, while group I showed an increase in DBP (p<0.05). After intubation, mean MAP increased from baseline in group I than group II observed a decrease in mean MAP from baseline (p>0.05) and it values at 5, 15, 30 min after intubation were lower in group II as compared to group I were significant (p<0.001). CONCLUSION: Nalbuphine controls the pressor response much better as compared to Fentanyl.

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“…Few studies have shown that Fentanyl, 15,16,17 or Nalbuphine 18,19 are effective in blunting pressor response anaesthetic agents to laryngoscopy and endotracheal intubation.…”

Section: Resultsmentioning

confidence: 99%

Attenuation of Haemodynamic Response to Endotracheal Intubation With Nalbuphine and Fentanyl: A Comparative Study

Bhandari¹,

Rastogi²,

Tyagi³

et al. 2015

jemds

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“…Although the haemodynamic response to fibreoptic orotracheal intubation (FOI) has been widely studied in adults [1][2][3][4][5][6][7][8], few relevant studies are available in children [9,10]. Although the haemodynamic response to fibreoptic orotracheal intubation (FOI) has been widely studied in adults [1][2][3][4][5][6][7][8], few relevant studies are available in children [9,10].…”

Section: Introductionmentioning

confidence: 99%

Blood pressure and heart rate changes during fibreoptic orotracheal intubation: a comparison of children and adults

Xue

Zhang

Hai

et al. 2006

EJA

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“…These changes were observed even after administration of fentanyl citrate, a drug known to reduce the pressor response. 28 The study also showed that hypertensive response to nasotracheal intubation was significantly greater and more sustained when compared to orotracheal intubation (P<0.001). This is similar with the previous observation done by Smith JE et al 12 It seems likely that the nasotracheal intubation produces a greater mechanical stimulation of the upper airway and that this generates a more vigorous activation of sympathetic nervous system.…”

Section: 12mentioning

confidence: 65%

Reflex circulatory responses after three stages of nasotracheal intubation and two stages of orotracheal intubation: A comparative study

et al. 2017

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Background: Endotracheal intubation has become the mainstay of modern anaesthesia. Stimulation of upper respiratory tract during tracheal intubation under general anaesthesia causes activation of sympatho-adrenal system and results in increased serum catecholamines. Aims and Objectives: To identify and compare the hemodynamic responses contributed by each stage of nasotracheal with that of orotracheal intubation. Material and Methods: About 125 patients in the age group 18-50 years, ASA physical status I-II of either sex, scheduled to undergo various elective surgical procedures requiring nasotracheal or orotracheal intubation were evaluated in the present study.After 4 minutes of ventilation, patients requiring nasal intubation (n=75) were allocated to three groups-nasopharyngeal intubation group (NPI), nasopharyngeal intubation with laryngoscopy group (NPIL) and nasotracheal intubation group (NTI). Those requiring oral intubation (n=50) were allocated to two groups namely-laryngoscopy only group (L) and laryngoscopy followed by orotracheal intubation group (OTI). Haemodynamic parameters like heart rate and blood pressure, SpO2, ECG, ETCO 2 were monitored continuously and data were recorded before induction, just after induction and after intubation at one minute interval for five minutes. Results: The pre-induction and pre-procedure values of systolic, diastolic and mean arterial pressures and also heart rate were similar in each group (P<0.05). Induction of anaesthesia caused a significant decrease in systolic, diastolic and mean arterial pressures in all groups compared to their pre-induction values (P<0.0012). Our study showed that systolic, diastolic and mean arterial pressures were significantly increased after intubation procedures in all the five groups compared to pre-procedure values. Conclusion: All the procedures evoked cardiovascular responses characterized by increases in heart rate and blood pressure. NTI produced a significant rise in blood pressure.

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Effect of fentanyl on the circulatory responses to orotracheal fibreoptic intubation

Abstract: Summary

Cited by 22 publications

References 13 publications

Attenuation of Haemodynamic Response to Endotracheal Intubation With Nalbuphine and Fentanyl: A Comparative Study

Attenuation of Haemodynamic Response to Endotracheal Intubation With Nalbuphine and Fentanyl: A Comparative Study

Blood pressure and heart rate changes during fibreoptic orotracheal intubation: a comparison of children and adults

Reflex circulatory responses after three stages of nasotracheal intubation and two stages of orotracheal intubation: A comparative study

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