Effect of fenugreek supplementation on blood lipids and body weight: A systematic review and meta-analysis of randomized controlled trials

Askarpour, Moein; Alami, Farkhondeh; Campbell, Marilyn S.; Venkatakrishnan, Kamesh; Hadi, Amir; Ghaedi, Ehsan

doi:10.1016/j.jep.2019.112538

Cited by 15 publications

(7 citation statements)

References 38 publications

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“…Fenugreek may increase insulin sensitivity by enhancing insulin action at the cellular level, lowering HbA1c levels by using glucose in the peripheral tissues and maintaining blood glucose levels [ 32 , 33 , 34 , 35 ]. Not only does fenugreek affect blood sugar, but multiple reviews also suggest a role in the improvement of lipid profiles, making it suitable for metabolic disorders [ 4 , 9 , 24 , 35 , 36 ]. It could be possible that there are interrelated mechanisms of action of fenugreek where its biochemical properties could be related to the metabolism of sugar, lipid, or both [ 35 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

“…Not only does fenugreek affect blood sugar, but multiple reviews also suggest a role in the improvement of lipid profiles, making it suitable for metabolic disorders [ 4 , 9 , 24 , 35 , 36 ]. It could be possible that there are interrelated mechanisms of action of fenugreek where its biochemical properties could be related to the metabolism of sugar, lipid, or both [ 35 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

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Effect of Fenugreek on Hyperglycemia: A Systematic Review and Meta-Analysis

et al. 2023

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Fenugreek is used for medicinal purposes in various traditions. Some studies have demonstrated that the seeds of this plant may have an anti-diabetic effect by lowering fasting blood sugar levels and improving glucose tolerance. We conducted a systematic review of the hypoglycemic effects of fenugreek. An electronic literature search was carried out in the PubMed, Google Scholar, Scopus, and Cochrane Library databases through 18 November 2022 to find trials that assessed fasting blood glucose, postprandial blood glucose, and HbA1c changes in participants treated with fenugreek and in the control group. The mean difference with 95% confidence intervals (CI) was calculated to represent the analysis. Fourteen trials, consisting of 894 participants, were included in the meta-analysis. The results showed a reduction in fasting blood glucose levels (MD: 3.70, 95% CI of −27.02, 19.62; p = 0.76), postprandial blood glucose (MD: −10.61, 95% CI of −68.48, 47.26; p = 0.72), and HbA1c (MD: −0.88, 95% CI −1.49, −0.27; p = 0.00) with fenugreek consumption. While this review and included trials that found beneficial effects of fenugreek consumption on glycemic control, the quality and heterogeneity of studies remain a concern. Given the wider availability and lower cost of fenugreek, rigorous double-blinded randomized controlled trials should be conducted with fenugreek to understand its true potential as a diabetes control herbal agent.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of Fenugreek on Hyperglycemia: A Systematic Review and Meta-Analysis

et al. 2023

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“…Moreover, findings from randomized controlled trials administering nuts as intervention arm confirm their potential effects on total and low-density lipoprotein cholesterol [ 149 ]. Concerning seeds, only a minority of studies have been conducted on commercial products, such as sesame [ 150 , 151 ], fenugreek [ 152 ], and flaxseeds [ 153 , 154 ] reporting significant effects of markers of inflammation and CVD risk factors, albeit not with univocal result [ 155 – 157 ]. These energy-rich foods are characterized by richness in essential fatty acids and fiber that may be responsible for their cholesterol-lowering properties [ 158 ].…”

Section: Underrated Aspects Of the Mediterranean Dietmentioning

confidence: 99%

Underrated aspects of a true Mediterranean diet: understanding traditional features for worldwide application of a “Planeterranean” diet

Godos,

Scazzina,

Paternò Castello

et al. 2024

J Transl Med

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Over the last decades, the Mediterranean diet gained enormous scientific, social, and commercial attention due to proven positive effects on health and undeniable taste that facilitated a widespread popularity. Researchers have investigated the role of Mediterranean-type dietary patterns on human health all around the world, reporting consistent findings concerning its benefits. However, what does truly define the Mediterranean diet? The myriad of dietary scores synthesizes the nutritional content of a Mediterranean-type diet, but a variety of aspects are generally unexplored when studying the adherence to this dietary pattern. Among dietary factors, the main characteristics of the Mediterranean diet, such as consumption of fruit and vegetables, olive oil, and cereals should be accompanied by other underrated features, such as the following: (i) specific reference to whole-grain consumption; (ii) considering the consumption of legumes, nuts, seeds, herbs and spices often untested when exploring the adherence to the Mediterranean diet; (iii) consumption of eggs and dairy products as common foods consumed in the Mediterranean region (irrespectively of the modern demonization of dietary fat intake). Another main feature of the Mediterranean diet includes (red) wine consumption, but more general patterns of alcohol intake are generally unmeasured, lacking specificity concerning the drinking occasion and intensity (i.e., alcohol drinking during meals). Among other underrated aspects, cooking methods are rather simple and yet extremely varied. Several underrated aspects are related to the quality of food consumed when the Mediterranean diet was first investigated: foods are locally produced, minimally processed, and preserved with more natural methods (i.e., fermentation), strongly connected with the territory with limited and controlled impact on the environment. Dietary habits are also associated with lifestyle behaviors, such as sleeping patterns, and social and cultural values, favoring commensality and frugality. In conclusion, it is rather reductive to consider the Mediterranean diet as just a pattern of food groups to be consumed decontextualized from the social and geographical background of Mediterranean culture. While the methodologies to study the Mediterranean diet have demonstrated to be useful up to date, a more holistic approach should be considered in future studies by considering the aforementioned underrated features and values to be potentially applied globally through the concept of a “Planeterranean” diet.

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“…Despite the popularity of fenugreek, most of these above-mentioned claims await verification and scientific proof [ 4 ]. Some of the studies done on fenugreek report that it has galactagogue [ 7 , 8 ], anti-inflammatory [ 9 , 10 ], antidiabetic [ 10 ], anticholesterolemic [ 11 , 12 ], antihypertensive, kidney and liver protective [ 13 ], androgenic/anabolic [ 14 ], antibacterial, and anticancer [ 15 ] properties. All these medicinal uses and properties show how popular and beneficial this herb is in such a broad spectrum of disease conditions.…”

Section: Introductionmentioning

confidence: 99%

Trigonella foenum-graecum Methanolic Extract on Isolated Smooth Muscles and Acetylcholinesterase Enzyme: An In Vitro and Mechanistic In Silico Investigation

Ghayur

Abdalla

Khalid

et al. 2022

BioMed Research International

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Background and Objective. Trigonella foenum-graecum Linn., also called fenugreek, is a popular medicinal plant cultivated all over the globe. Fenugreek seeds are known for their many medicinal properties. We present our findings on the effect of a 70% aqueous methanolic fenugreek seed extract (Tfg.Cr) on isolated GI smooth muscles (rabbit jejunum and rat ileum) and the effect of extract and its constituent diosgenin on acetylcholinesterase (AChE) enzyme. Results. When tested on the baseline of isolated tissues, Tfg.Cr was devoid of any activity (stimulant or relaxant) till 10 mg/ml. This is an interesting finding, keeping in mind that the fenugreek seeds are used to alleviate constipation and diarrhoea. When Tfg.Cr was tried for any potential AChE inhibitory activity, it did show an inhibitory effect in increasing concentrations (47-380 μg/ml). This inhibitory effect was comparable to the effect produced by a standard AChE inhibitor physostigmine. One of the known fenugreek constituents, diosgenin, was also tested, and it also showed an AChE inhibitory effect in a concentration-dependent manner (11-190 μg/ml). Interaction between diosgenin and AChE was further investigated by molecular docking and molecular dynamics simulations for 100 ns, which showed that diosgenin interacted with the active-site gorge of AChE through hydrophobic, pi-pi stacking, and hydrogen bonds with various amino acids of the AChE enzyme. Conclusion. The results show that the fenugreek extract does not possess any GI stimulant or relaxant activity even though it is used traditionally in GI motility disorders. The extract and diosgenin could inhibit the AChE enzyme pointing towards their benefit to enhance the memory.

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Effect of fenugreek supplementation on blood lipids and body weight: A systematic review and meta-analysis of randomized controlled trials

Cited by 15 publications

References 38 publications

Effect of Fenugreek on Hyperglycemia: A Systematic Review and Meta-Analysis

Effect of Fenugreek on Hyperglycemia: A Systematic Review and Meta-Analysis

Underrated aspects of a true Mediterranean diet: understanding traditional features for worldwide application of a “Planeterranean” diet

Trigonella foenum-graecum Methanolic Extract on Isolated Smooth Muscles and Acetylcholinesterase Enzyme: An In Vitro and Mechanistic In Silico Investigation

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