In this study, the effects of co-fermentation on maize and soybean blends, with respect to their proximate composition, antinutrients, amino acid profile and sensory properties, were determined. The co-fermented blend did not differ significantly (p >0.05) from the separately fermented blend in terms of protein, carbohydrate and ash contents. However, fat and energy contents of the co-fermented flour blend were higher; 12.16% dry matter and 426.57 kcal/100g respectively. The cofermented maize and soybean flour blend was lower in tannins (0.046 g/100g) but higher in trypsin inhibitory activity (1.04 TUI/mg) than the separately fermented blend (0.06 g/100g and 0.64 TUI/mg respectively). Furthermore, the separately fermented sample had higher contents of six essential amino acids: lysine, isoleucine, phenylalanine, tryptophan, valine and threonine, than the co-fermented sample, which was limiting in lysine. The sensory scores for the samples did not differ significantly between the two blends. Consequently, co-fermentation can be employed as a simple time and resource-saving house-hold preparation method for complementary flours from cereals and legumes.