Effect of fermented bee pollen on metabolic syndrome in high-fat diet-induced mice

Yan, Sha; Wang, Kai; Wang, Xiaoying; Ou, Aiqun; Wang, Feiran; Wu, Liming; Xue, Xiao‐Feng

doi:10.1016/j.fshw.2021.02.026

Cited by 17 publications

(14 citation statements)

References 39 publications

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“…Studies have demonstrated the positive effects of the phenolic and probiotic content of bee pollen on preventing metabolic syndrome by reducing body and liver weight gain, decreasing fasting blood glucose, and lipid accumulation in serum and liver, which can be explained through the regulation of intestinal microbiota [ 255 ].…”

Section: Therapeutic Properties Of Bee Pollen Against Oxidative Stres...mentioning

confidence: 99%

Bee Pollen as Functional Food: Insights into Its Composition and Therapeutic Properties

et al. 2023

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Bee pollen is a hive product made up of flower pollen grains, nectar, and bee salivary secretions that beekeepers can collect without damaging the hive. Bee pollen, also called bee-collected pollen, contains a wide range of nutritious elements, including proteins, carbs, lipids, and dietary fibers, as well as bioactive micronutrients including vitamins, minerals, phenolic, and volatile compounds. Because of this composition of high quality, this product has been gaining prominence as a functional food, and studies have been conducted to show and establish its therapeutic potential for medical and food applications. In this context, this work aimed to provide a meticulous summary of the most relevant data about bee pollen, its composition—especially the phenolic compounds—and its biological and/or therapeutic properties as well as the involved molecular pathways.

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Section: Therapeutic Properties Of Bee Pollen Against Oxidative Stres...mentioning

confidence: 99%

Bee Pollen as Functional Food: Insights into Its Composition and Therapeutic Properties

et al. 2023

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“…It has been found that L. acidophilus LA5 could improve the saturated fat-induced obesity mouse model through the enhanced intestinal Akkermansia muciniphila ( 5 ). L. acidophilus NX2-6 showed the potential against oleic acid-induced steatosis, mitochondrial dysfunction, endoplasmic reticulum stress, and inflammatory responses ( 6 ). L. acidophilus SNZ 86 could alleviate Western diet-induced non-alcoholic fatty liver disease in rats via modulation of autophagy through the AMPK/SIRT-1 pathway ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

“…Because the pathogenesis of NAFLD is still unclear, studies are ongoing to develop an effective treatment protocol for NAFLD (3). Natural products incorporated into diets (ginkgolide C, polyphenols, yeast-fermented wall-broken bee pollen, among others) could be effective against NAFLD (5)(6)(7). Furthermore, next-generation sequencing techniques have revealed a possible correlation between NAFLD pathogenesis and changes in the intestinal microbiome (8), thus offering a potential strategy for diet-induced NAFLD (9).…”

Section: Introductionmentioning

confidence: 99%

Assessing the in vivo ameliorative effects of Lactobacillus acidophilus KLDS1.0901 for induced non-alcoholic fatty liver disease treatment

Wang

Yang

et al. 2023

Front. Nutr.

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Reputed as a significant metabolic disorder, non-alcoholic fatty liver disease (NAFLD) is characterized by high-fat deposits in the liver and causes substantial economic challenges to any country's workforce. Previous studies have indicated that some lactic acid bacteria may effectively prevent or treat NAFLD. Overall, L. acidophilus KLDS1.0901 protected against HFD-induced NAFLD by improving liver characteristics and modulating microbiota composition, and thus could be a candidate for improving NAFLD. This study aimed to assess the protective effects of L. acidophilus KLDS1.0901 on a high-fat diet(HFD)-induced NAFLD. First, hepatic lipid profile and histological alterations were determined to study whether L. acidophilus KLDS1.0901 could ameliorate NAFLD. Then, the intestinal permeability and gut barrier were explored. Finally, gut microbiota was analyzed to elucidate the mechanism from the insights of the gut–liver axis. The results showed that Lactobacillus KLDS1.0901 administration significantly decreased body weight, Lee's index body, fat rate, and liver index. L. acidophilus KLDS1.0901 administration significantly improved lipid profiles by decreasing the hepatic levels of total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) and by increasing the high-density lipoprotein cholesterol (HDL-C) levels. A conspicuous decrease of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum was observed after L. acidophilus KLDS1.0901 administration. Meanwhile, the H&E and Oil Red O-stained staining showed that L. acidophilus KLDS1.0901 significantly reduced liver lipid accumulation of HFD-fed mice by decreasing the NAS score and lipid area per total area. Our results showed that L. acidophilus KLDS1.0901 administration decreased the interleukin-6 (IL-6), interleukin-1β (IL-1β), and tumor necrosis factor-alpha (TNF-α) concentrations accompanied by the increase of interleukin-10 (IL-10). L. acidophilus KLDS1.0901 administration could improve the intestinal barrier function by upregulating the mRNA levels of occludin, claudin-1, ZO-1, and Muc-2, which were coupled to the decreases of the concentration of LPS and D-lactic acid. Notably, L. acidophilus KLDS1.0901 administration modulated the gut microbiota to a near-normal pattern. Hence, our results suggested that L. acidophilus KLDS1.0901 can be used as a candidate to ameliorate NAFLD.

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“…Antioxidants present in the food can significantly improve the oxidative state of the body and help to maintain the oxidative/antioxidant balance in the gut ( 14 , 15 ). The use of food proteins and their constituent peptides which exhibit relatively fewer side effects as antioxidants can serve as an effective approach.…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Oyster Peptides Derived From Crassostrea gigas on Intestinal Oxidative Damage Induced by Cyclophosphamide in Mice Mediated Through Nrf2-Keap1 Signaling Pathway

Chen

Zheng

et al. 2022

Front. Nutr.

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Oyster peptide (OP) has exhibited useful biological activities and can be used in multi-functional foods. OP has been reported to play a significant role in intestinal protection, but its specific mechanism is still not completely understood. The aim of this study was to analyze the potential effect of OP on oxidative damage of mice intestine induced by cyclophosphamide (Cy). The experimental results revealed that intragastric administration of OP significantly increased average bodyweight, improved ileum tissue morphology and villus structure, as well as increased the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in oxidized mice serum and liver. The content of malondialdehyde (MDA) in the mice serum and liver homogenate was found to be markedly decreased. Moreover, OP significantly increased the relative mRNA expression levels of superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), quinone oxidoreductase (NQO1) and heme oxidase-1 (HO-1) in ileum. Western-blot results indicated that prior administration of OP significantly up-regulated the Nrf2 production in ileum, and substantially decreased then Keap1 gene expression. In conclusion, intake of OP was found to markedly improve intestinal oxidative stress in vivo, and this effect was primarily mediated through the simulation of antioxidant Nrf2-Keap1 signaling pathway. This study is beneficial to the application of peptide nutrients in the prevention or mitigation of intestinal oxidative damage.

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Effect of fermented bee pollen on metabolic syndrome in high-fat diet-induced mice

Cited by 17 publications

References 39 publications

Bee Pollen as Functional Food: Insights into Its Composition and Therapeutic Properties

Bee Pollen as Functional Food: Insights into Its Composition and Therapeutic Properties

Assessing the in vivo ameliorative effects of Lactobacillus acidophilus KLDS1.0901 for induced non-alcoholic fatty liver disease treatment

Protective Effect of Oyster Peptides Derived From Crassostrea gigas on Intestinal Oxidative Damage Induced by Cyclophosphamide in Mice Mediated Through Nrf2-Keap1 Signaling Pathway

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