Effect of fermented soybean products intake on the overall immune safety and function in mice

Lee, Jae Hee; Paek, Se Hee; Shin, Hye Won; Lee, Seung Yeon; Moon, Byoung Seok; Park, Jung Eun; Lim, Gyeong Dong; Kim, Chang Yul; Heo, Yong

doi:10.4142/jvs.2017.18.1.25

Cited by 16 publications

(12 citation statements)

References 39 publications

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“…Cheonggukjang intake can improve plasma lipid profiles and fasting blood glucose levels in subjects with impaired fasting glucose control [14]. In addition, cheonggukjang intake produces an inhibitory effect on allergic asthma that is exacerbated by histamine release from mast cells, as well as other allergic responses [15,16].…”

Section: Introductionmentioning

confidence: 99%

Secondary Fermented Extract of Chaga-Cheonggukjang Attenuates the Effects of Obesity and Suppresses Inflammatory Response in the Liver and Spleen of High-Fat Diet-Induced Obese Mice

Park

Kim

et al. 2019

Journal of Microbiology and Biotechnology

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Cheonggukjang and chaga mushrooms have numerous health benefits, and have been used in alternative medicine. Therefore, a powder mixture of 98: Cheonggukjang and 2: Chaga extracts was fermented with Lactobacillus acidophilus KCTC3925 (FCC) and its anti-obesity effects in high-fat diet (HFD)-induced obese mice were determined. Five-week-old male ICR mice were fed a normal diet or HFD in the presence or absence of 3% and 5% FCC by weight (n = 10 per group). After 12 weeks, the mice were sacrificed, and the serum and tissue samples were collected for analysis. Body weight and epididymal fat pad weight were significantly lowered in the 3% and 5% FCC groups compared with those in the HFD control group (p < 0.01). FCC supplementation suppressed serum triglyceride and increased serum HDL-C levels (p < 0.01). Serum GOT, GPT, and leptin levels, hepatic COX-2 mRNA expression, and splenic COX-2 and IL-4 mRNA expression were significantly higher in the HFD groups than in the control group (p > 0.05); however, except for splenic IL-4 levels, the increases were significantly attenuated by FCC supplementation. Expression of ICAM-1, an aortic inflammatory marker, was significantly increased in the HFD group; this effect was suppressed in the 3% FCC group (p < 0.01) but not in the 5% FCC group. FCC suppressed the body weight and epididymal fat pad weight gain, as well as inflammatory responses in the liver and spleen of HFD-fed mice. Thus, FCC supplementation will be beneficial for the treatment of obesity-related effects.

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Section: Introductionmentioning

confidence: 99%

Secondary Fermented Extract of Chaga-Cheonggukjang Attenuates the Effects of Obesity and Suppresses Inflammatory Response in the Liver and Spleen of High-Fat Diet-Induced Obese Mice

Park

Kim

et al. 2019

Journal of Microbiology and Biotechnology

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“…Single-cell suspensions of spleen cells were prepared, as described elsewhere (Lee et al, 2017). Splenic T cells were stimulated in vitro with an immobilized anti-CD3 monoclonal antibody (mAb) (5 µg/5 × 10 5 cells; BD Biosciences) and 10 IU human recombinant interleukin (IL)-2 (PeproTech, Rocky Hill, New Jersey, USA) for 48 h at 37°C in a 5% CO 2 incubator.…”

Section: Methodsmentioning

confidence: 99%

“…IL-4, interferon-γ (IFN-γ), and tumor necrosis factor-α (TNF-α) were measured in culture supernatants using the OptEIA ELISA sets (BD Biosciences) as a paired capture and detection antibody, as described elsewhere (Lee et al, 2017). Serum immunoglobulin E (IgE) and IgA levels were determined by sandwich ELISA using antimouse IgE or IgA mAb as the capture Ab and biotinylated antimouse IgE or IgA mAb as the detection Ab (BD Biosciences).…”

Section: Methodsmentioning

confidence: 99%

Dysregulation of murine immune functions on inhalational exposure to ammonia, dimethyl disulfide, 3-methylindole, or propionic acid

et al. 2021

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Animal husbandry workers are exposed to various malodorous compounds in the workplace. Although these compounds cause severe nuisance, no systemic investigation of their effects on the immune system has been conducted. To address this issue, we evaluated the effects of inhalational exposure to ammonia, dimethyl disulfide, 3-methylindole (3-MI), and propionic acid (PA), representing four major groups of malodorous compounds, on humoral and cellular immunity in mice. Mice were exposed to the substances (low dose: 10 µL and high dose: 200 µL) for 10 min/day for 4 weeks in a modified standard mouse cage. Neutrophil% and splenic cytotoxic T cell% were significantly lower in the high-dose ammonia group than in the vehicle control. Exposure to ammonia and 3-MI increased immature thymic T lymphocyte% relative to control and concomitantly decreased both mature helper and cytotoxic T-cell populations in the thymus. In the ammonia exposure group, levels of serum immunoglobulin E and immunoglobulin A were elevated, and the IgG2a:IgG1 ratio in the serum was reduced in a dose-dependent manner. Splenic natural killer cell activity was significantly less in the PA exposure group than in the control. Overall, our findings suggest that inhalational exposure to these malodorous substances disturbs immune homeostasis in vivo.

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“…Hyriopsis cumingii polysaccharides in dose-dependent manner promote IL-2 and IFN-γ production in vivo (Qiao et al, 2017). Doenjang and Cheonggukjang, two fermented soybean products, can upregulate production ratio of IFN-γ to IL-4 in stimulated splenic T-and B-lymphocytes (Lee et al, 2017). Fermented mung bean and soybean can increase IL-2 by 1.7-and 1.9-fold, and enhance IFN-γ by 15-and 18-fold, respectively (Ali et al, 2015).…”

Section: Groupsmentioning

confidence: 99%

Immune potentials of theMucor-fermented Mao-tofu and especially its soluble extracts for the normal mice

Liu

Zhao

2017

Food and Agricultural Immunology

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Mao-tofu was fermented for 6 days with a Mucor strain and extracted with pH 6.5 water and 40% ethanol to generate respective two extracts. Immune potentials of Mao-tofu and two extracts were assessed, via assessing the changes of several immune indices related to immune organs, cells, and molecules in normal mice. Compared with the unfermented tofu, Mao-tofu had somewhat higher immune activities towards the mice in all cases, indicating improved immune potential by the Mucor-mediated fermentation. More important, two extracts (especially water extract) had much higher immune activities towards the mice than Mao-tofu (P < .05). Two extracts were in dose-dependent manner to improve immune status of the mice, via increasing spleen and thymus indices, percentages of T-helper (CD4+) and T-cytotoxic (CD8+) lymphocytes in plasma, serum contents of two complements (C3 and C4) and Th1 cytokines (IL-2 and IFN-γ), but decreasing serum contents of Th2 cytokines (IL-4, IL-5, and IL-10).

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Effect of fermented soybean products intake on the overall immune safety and function in mice

Cited by 16 publications

References 39 publications

Secondary Fermented Extract of Chaga-Cheonggukjang Attenuates the Effects of Obesity and Suppresses Inflammatory Response in the Liver and Spleen of High-Fat Diet-Induced Obese Mice

Secondary Fermented Extract of Chaga-Cheonggukjang Attenuates the Effects of Obesity and Suppresses Inflammatory Response in the Liver and Spleen of High-Fat Diet-Induced Obese Mice

Dysregulation of murine immune functions on inhalational exposure to ammonia, dimethyl disulfide, 3-methylindole, or propionic acid

Immune potentials of theMucor-fermented Mao-tofu and especially its soluble extracts for the normal mice

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