Effect of Ferrous Ion on Tyrosine Hydroxylase of Bovine Adrenal Medulla

Petrack, Barbara; Sheppy, Fred; Fetzer, Valentina; Manning, Thomas A.; Chertock, Herbert; Ma, Daniel

doi:10.1016/s0021-9258(19)44992-2

Cited by 28 publications

(1 citation statement)

References 14 publications

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“…These results suggest that protein oxidation in the presence of Fe2+ and 02 may be a general phenomenon.2 The potential oxidizability of ferrous ion-protein systems should be of interest because of the participation of Fe2+ in many enzymic reactions and the not infrequently observed instability of such enzymes. A recent example is the rapid irreversible loss of activity by tyrosine hydroxylase when incubated with Fe2+ in air (Petrack et al, 1972).…”

Section: Discussionmentioning

confidence: 99%

Oxidative modification of proteins in the presence of ferrous ion and air. Effect of ionic constituents of the reaction medium on the nature of the oxidation products

Taborsky¹,

McCollum²

1973

Biochemistry

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c X^Vertain aspects of an earlier study of the aerobic reduction of ferricytochrome c by ferrous ion implied that the reaction might involve not only the heme group but also the protein moiety of the cytochrome molecule (Taborsky, 1972). In this article, we give evidence that the protein undergoes an oxidative modification in the course of the reaction. It is likely that this oxidation is a general feature of the aerobic interaction between proteins and ferrous ion, but cytochrome c appears to be particularly susceptible. This study also revealed that the oxidative modification of proteins is markedly affected by the ionic constitution of the reaction medium.

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Section: Discussionmentioning

confidence: 99%