Effect of fetal hypophysectomy on the initiation of parturition in the goat

Rawlings, N. C.; Ward, W. R.

doi:10.1530/jrf.0.0520249

Cited by 11 publications

(1 citation statement)

References 10 publications

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“…This phenomenon is pituitary dependent [3,4]. Intrafetal infusion of ACTHI_ 2 4 induces premature labor, suggesting that endogenous ACTH secretion drives the cortisol surge under normal conditions.…”

Section: Introductionmentioning

confidence: 96%

Fetal and Maternal Endocrine Changes Approaching Parturition in the Goat: Lack of Evidence for Prostaglandins E2 and F2α as Signals for Luteolysis1

Ford

Young

Caddy

et al. 1998

Biology of Reproduction

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We investigated the temporal relationship of fetal cortisol secretion to circulating concentrations of fetal ACTH1-39 and its high-molecular weight precursors in goats. We also measured the concentrations of progesterone, estradiol-17beta estrone sulfate, prostaglandin (PG) E, PGF2alpha, and PGF2alpha metabolite (PGFM) in maternal arterial plasma over the last month of gestation. Prostaglandin concentrations were also measured in utero-ovarian venous plasma. There was a positive association between ACTH1-39 in fetal plasma and the prepartum surge in fetal cortisol that commenced 8 days before labor. The fetal cortisol surge was followed by a simultaneous decrease in maternal progesterone and an increase in plasma estrogens commencing 3-4 days before labor. No change in basal prostaglandin concentration occurred before this time. There was a positive veno-arterial difference of PGE and PGF2alpha across the uterine vascular bed, confirming the uteroplacental unit as a major source of these eicosanoids in the plasma of the pregnant doe. We conclude that the fetal signal for parturition precedes luteolysis by some 5 days and find no evidence of changes in the basal concentrations of PGE and PGF2alpha in maternal plasma at the time of luteolysis.

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Section: Introductionmentioning

confidence: 96%

Fetal and Maternal Endocrine Changes Approaching Parturition in the Goat: Lack of Evidence for Prostaglandins E2 and F2α as Signals for Luteolysis1

Ford

Young

Caddy

et al. 1998

Biology of Reproduction

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The ultrastructure of the pituitary and the adrenal gland of three newborn marsupials (Dasyurus hallucatus, Trichosurus vulpecula and Isoodon macrourus)

Gemmell

Nelson

1988

Anat Embryol

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The ultrastructure of the pituitary glands of the newborn northern native cat, brushtail possum and the northern brown bandicoot and the adrenal glands of the former two marsupials were examined to determine whether these endocrine glands were functional at birth. The anterior pituitary of all three species was well vascularised and many cells contained electron-dense, membrane bound granules. The adrenal glands were composed of two distinct cell populations. One group of cells possessed dark staining granules, normally observed in catecholamine-secreting cells, and the second group contained large amounts of smooth endoplasmic reticulum and mitochondria with tubulovesicular cristae, indicative of steroid hormone secreting cells. The ultrastructure of the cells of the fetal pituitary and adrenal of all three species would suggest that these glands are functional at birth and, as with many eutherians, the marsupial pituitary and adrenal gland may play an important role in determining the length of gestation.

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Fetal and maternal endocrine changes associated with parturition in the goat

Rawlings

Ward

1978

Theriogenology

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Effect of fetal hypophysectomy on the initiation of parturition in the goat

Cited by 11 publications

References 10 publications

Fetal and Maternal Endocrine Changes Approaching Parturition in the Goat: Lack of Evidence for Prostaglandins E2 and F2α as Signals for Luteolysis1

Fetal and Maternal Endocrine Changes Approaching Parturition in the Goat: Lack of Evidence for Prostaglandins E2 and F2α as Signals for Luteolysis1

The ultrastructure of the pituitary and the adrenal gland of three newborn marsupials (Dasyurus hallucatus, Trichosurus vulpecula and Isoodon macrourus)

Fetal and maternal endocrine changes associated with parturition in the goat

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