Effect of Fiber and Its Fermentation on Colonic Adaptation After Cecal Resection in the Rat

Abstract

Cecal resection leads to significant functional and structural changes in the adapting residual colon. Fermentation of dietary fiber by colonic flora to short-chain fatty acids is necessary, but it alone is not sufficient to mediate adaptation.

Effect of dietary fiber on intestinal barrier function of 5-Fu stressed rats

“…Other studies also demonstrated that DF improved adaptation of small intestine and colon after intestinal resection [4,14], decreased colonic mucosal atrophy [15] and methotrexateinduced intestinal injury [16].…”

“…Three mechanisms might be included in the beneficial effects of DF on the colon [14]: (1) a direct action of fiber substrates on the colonic mucosa;…”

“…The attention was, however, focused on the effects of DF on bowel function and intestinal adaptation after intestinal resection [3][4][5]. Some animal experiments about the effects of DF on the IBF have been performed and have provided encouraging results, but little was known about the effects of DF on chemotherapy-induced damage of IBF.…”

Success with Intestinal Failure: From Adaptation to Transplantation

“…Foods and medications that have laxative effects, late, which increases the amount of soluble oxalate available for absorption. Colonic permeability to oxalate is such as caffeine, magnesium and sorbitol elixirs, should [11] bowel transit [8]. Octreotide may also decrease fat absorpShort-chain fatty acid [7] tion, and increase the risk of gallstones, if given long Glutamine [12][13][14] term.…”

“…Commercial pro-substances, such as growth hormone, glutamine, and fiber exert bowel-specific trophic effects that appear to influducts such as Ceralyte-70 or 90 can be used. Sport drinks such as Gatorade have limited sodium concentrations ence nutrient absorption [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27] (table 1). Byrne et al [28] reported, in an uncontrolled study of 8 patients with and are inappropriate for electrolyte replacement in the short bowel patient unless salt is added (i.e.…”