Effect of Ficus carica L. leaves extract loaded gold nanoparticles against cisplatin-induced acute kidney injury

El‐Sayed, Samah M.; El‐Naggar, Mehrez E.; Hussein, Jihan; Medhat, Dalia; El-Banna, Mona

doi:10.1016/j.colsurfb.2019.110465

Cited by 44 publications

(23 citation statements)

References 29 publications

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“…The elevation of the antioxidant activity of plant nano-extracts referred to increasing the total polyphenolic compounds and other active phytoconstituents after incorporating silver nanoparticles (Ag-NPs) [15]. Moreover, there is no obvious toxicity occurred in animal organs after oral administration of the silver plant nano-extracts [16].…”

Section: Introductionmentioning

confidence: 99%

Comparative Study between Croton tiglium Seeds and Moringa oleifera Leaves Extracts, after Incorporating Silver Nanoparticles, on Murine Brains

et al. 2021

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Croton tiglium seeds and Moringa oleifera leaves extracts are rich in phytoconstituents with the antioxidant efficiency which can be enhanced by incorporating silver nanoparticles (Ag-NPs). The present study was designed to compare the effect of C. tiglium seeds and M. oleifera leaves nano-extracts on brain tissues of murine models. During the current study, acetylcholine esterase (ACHE), β-amyloid (Aβ) content and inflammatory markers were measured in brain tissues. Moreover, native protein, lipoprotein and isoenzymes patterns were electrophoretically detected. Also, the interferon-gamma (INF-γ) receptor protein was studied by molecular dynamic simulation to evaluate the significant alterations on brain tissues. It was found that ACHE, Aβ contents and inflammatory markers increased in C. tiglium nano-extract treated group at a dose of 6.5 ml/kg. Furthermore, it caused qualitative electrophoretic abnormalities represented by lowering similarity index (SI) values. Also, the resides range 119~127 represent the most reactive and flexible site in INF-γ receptor protein. On the other hand, it was shown that no significant differences were induced by silver M. oleifera nano-extract.

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Section: Introductionmentioning

confidence: 99%

Comparative Study between Croton tiglium Seeds and Moringa oleifera Leaves Extracts, after Incorporating Silver Nanoparticles, on Murine Brains

et al. 2021

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“…[2]. The antimicrobial fabrics should achieve the following requirement to be applicable to injured skin as wound dressing [3,4]. These requirements include the fabrics should be nontoxic, not make bacterial resistance, should not cause allergic reaction, have broad spectrum antimicrobial and should be sustainable [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Chemical synthesis of silver nanoparticles in its solid state: highly efficient antimicrobial cotton fabrics for wound healing properties

et al. 2021

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Nanoparticles have been used as effective platforms for treating skin wounds over the last decade. Potential therapeutic effects on wound healing have been demonstrated through metal nanoparticles, notably silver nanoparticles (AgNPs). Solid state synthesis was used in this work for the preparation of AgNPs without using any external chemicals or solvents. In this current work, dextran was used as reducing agent for silver ions and in the same time as stabilizer for the produced nanoparticles. AgNPs is readily synthesized by eco-grinding artlessly for dextran powder, sodium hydroxide beads. The efficacy of dextran as a dual function for the synthesis of AgNPs was assessed by adjusting the utilized concentration of silver nitrate. Ultra-violet visible spectroscopy (Uv-vis), transmission electron microscopy (TEM), dynamic light scattering (DLS), zeta potential, X-ray diffraction (XRD), field emission scanning electron microscope -dispersive X-ray (FESEM-EDX) are tools for AgNPs characterization. The resulting AgNPs were added to cotton fabrics at different concentrations. The cytotoxicity and antimicrobial activities of the treated fabrics were examined. The findings showed that the spherical shape was confirmed with a reasonable distribution of prepared AgNPs. In addition, the stability of AgNPs has been attained and values greater than -30 mv have been obtained. The findings also revealed that the nanoparticles were effectively distributed onto the surface of fabrics and penetrated into them. The cotton fabrics treated possess superior antimicrobial properties, which are determined by the process of disc diffusion to suppress pathogenic microbes. Furthermore, for human and non-human cell lines, the cell viability of the treated cotton fabrics has no toxicity effect. On that framework, the synthesis of AgNPs with high yield is based on solvent-free is also offered by one pot synthesis of silver nanoparticles that is eco-friendly, low cost, save effort and chemicals.

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“…4 It has been demonstrated that biodegradable polymers used to produce drug-loaded microparticles result in the drug being molecularly dispersed in amorphous form, thereby significantly improving the bioavailability of non-water-soluble drugs. 5 Over the past two decades, researchers have been exploring biodegradable nanomaterials for drug delivery [6][7][8][9][10][11][12][13][14][15] in which nanoparticles are frequently employed as oral, injectable or inhalable drug delivery systems whereby the drug is continuously released from the particles over a defined period of time. Drug-loaded nanoparticles fabricated with biodegradable polymers are promising candidates for oral delivery of poorly watersoluble drugs.…”

Section: Introductionmentioning

confidence: 99%

<p>Copolymer Composition and Nanoparticle Configuration Enhance in vitro Drug Release Behavior of Poorly Water-soluble Progesterone for Oral Formulations</p>

Zhang¹,

Zhang²,

Illangakoon³

et al. 2020

IJN

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Hypothesis: Developing oral formulations to enable effective release of poorly watersoluble drugs like progesterone is a major challenge in pharmaceutics. Coaxial electrospray can generate drug-loaded nanoparticles of strategic compositions and configurations to enhance physiological dissolution and bioavailability of poorly water-soluble drug progesterone. Experiments: Six formulations comprising nanoparticles encapsulating progesterone in different poly(lactide-co-glycolide) (PLGA) matrix configurations and compositions were fabricated and characterized in terms of morphology, molecular crystallinity, drug encapsulation efficiency and release behavior. Findings: A protocol of fabrication conditions to achieve 100% drug encapsulation efficiency in nanoparticles was developed. Scanning electron microscopy shows smooth and spherical morphology of 472.1±54.8 to 588.0±92.1 nm in diameter. Multiphoton Airyscan superresolution confocal microscopy revealed core-shell nanoparticle configuration. Fourier transform infrared spectroscopy confirmed presence of PLGA and progesterone in all formulations. Diffractometry indicated amorphous state of the encapsulated drug. UV-vis spectroscopy showed drug release increased with hydrophilic copolymer glycolide ratio while core-shell formulations with progesterone co-dissolved in PLGA core exhibited enhanced release over five hours at 79.9±1.4% and 70.7±3.5% for LA:GA 50:50 and 75:25 in comparison with pure progesterone without polymer matrix in the core at 67.0±1.7% and 57.5±2.8%, respectively. Computational modeling showed good agreement with the experimental drug release behavior in vitro.

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Effect of Ficus carica L. leaves extract loaded gold nanoparticles against cisplatin-induced acute kidney injury

Cited by 44 publications

References 29 publications

Comparative Study between Croton tiglium Seeds and Moringa oleifera Leaves Extracts, after Incorporating Silver Nanoparticles, on Murine Brains

Comparative Study between Croton tiglium Seeds and Moringa oleifera Leaves Extracts, after Incorporating Silver Nanoparticles, on Murine Brains

Chemical synthesis of silver nanoparticles in its solid state: highly efficient antimicrobial cotton fabrics for wound healing properties

<p>Copolymer Composition and Nanoparticle Configuration Enhance in vitro Drug Release Behavior of Poorly Water-soluble Progesterone for Oral Formulations</p>

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