Effect of fish oil treatment on plasma lipoproteins in type III hyperlipoproteinaemia

Mølgaard, Jørgen; Schenck, Henning yon; Lassvik, C.; Kuusi, Timo; Olsson, Anders

doi:10.1016/0021-9150(90)90053-l

Cited by 24 publications

(8 citation statements)

References 18 publications

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“…For humans in a clinical situation, it was stated that a higher level of 2-5 g EPA + DHA may be needed to generate positive effects (Barlow et al, 1990;Duthie and Barlow, 1992 Sinclair (1953); Parkinson et al (1994) Burr et al (1989);Dolecek et al (1989);Norell et al (1986); Kromhout et al (1985); Dolecek and Grandits (1991) Wahlqvist et al (1989) Sassen et al (1989; Leaf and Webber (1988); Landymore et al (1985) Dehmer et al (1988( ) Sanders et al (1989; Molgaard et al (1990); Sanders and Hinds (1992) Harris (1989); Sanders et al (1989) Harris ( Li and Steiner (1990); Saynor and Gillot (1988) BNF (1992) Gudbjarnason (1989) Saynor et al (1984) Long chain n-3 PUFA and inflammatory diseases Aside from their effects on CHD, the n-3 polyunsaturated fatty acids EPA and DHA have been implicated in the alleviation of symptoms of a number of diseases, including cancer. Supplements of n-3 PUFA have been shown to have beneficial effects in disease states such as rheumatoid arthritis, systemic lupus erythematosus and multiple sclerosis, and to be associated, in part, with a reduction in the formation of various pro-inflammatory eicosanoids (BNF, 1992).…”

Section: Long Chain N-3 Polyunsaturated Fatty Acids and Human Healthmentioning

confidence: 99%

Manipulation of then-3 polyunsaturated fatty acid composition of avian eggs and meat

Leskanich¹,

Noble²

1997

World's Poultry Science Journal

222

146

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An imbalance in the human dietary intake of various types of fatty acids has become apparent. Results of fundamental studies have shown specific and beneficial effects on human health and well-being through the consumption of the long chain n-3 polyunsaturated fatty acids, in particular eicosapentaenoic acid and docosahexaenoic acid, which play an important role in rectifying this imbalance. As a result of these observations, recent recommendations pertaining to the consumption of dietary fat have stressed the importance of consuming higher levels of these fatty acids. In addition to increasing oily fish consumption, intake of the n-3 polyunsaturates can be enhanced through the consumption of commonly occurring non-fish foods containing elevated levels of these fatty acids. The fatty acid composition of the lipids of avian egg yolk and muscle tissues may be modified to match human nutritional guidelines better by appropriately manipulating the fatty acid composition of the diet; for example, modifications of the avian diet have raised total n-3 fatty acid content in egg yolk to over 200mg. Beneficial effects on blood lipoprotein characteristics in humans who consumed eggs with such modified fatty acid contents have been recorded. As in the case of eggs, meaningful quantities of n-3 polyunsaturates have been incorporated into major poultry muscle tissues. Concerns have been expressed over the development of unacceptable odours in eggs and meat from birds fed diets with increased polyunsaturation. However, by using only high quality materials, limiting the amount of fish oil or fishmeal within the diet and optimising the provision of supplemental dietary antioxidants, the production of eggs and meat with increased n-3 polyunsaturates is practicable. Restricted feeding and different protein ASMUNDSON, V.S., JUKES, T.H., FYLER, H.M. and MAXWELL, M.L. (1938) The effect of certain polyunsaturated fatty acids into eggs. Poultry Science 68: 166 (abstract) levels to two strains of SCWL hybrids. Swedish Journal of Agricultural Research 8: 241-247 fish meals and fish oils in the ration on the flavor of the turkey. . (1972) Flavor studies with different levels and times of fish meal feeding and some flavor-imparting additives in broiler diets. Agroatzimalia 4: 53-62 ATKINSON, P.M., WHEELER, M.C., MENDELSOHN, D., PIENAAR, N. and CHETTY. N. (1987)Effects of a 4-week freshwater fish (trout) diet on platelet aggregation, platelet fatty acids, serum lipids and coagulation factors.

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Section: Long Chain N-3 Polyunsaturated Fatty Acids and Human Healthmentioning

confidence: 99%

Manipulation of then-3 polyunsaturated fatty acid composition of avian eggs and meat

Leskanich¹,

Noble²

1997

World's Poultry Science Journal

222

146

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“…This exercise afforded the opportunity to ask if olive oil (the most commonly used placebo in these trials) was truly neutral vis-~t-vis circulating lipid levels. In the 33 data sets that used olive oil (or its ethyl esters) (5,7,9,12,(16)(17)(18)(19)(20)23,25,27,31,33,34,36,37,40,42,(44)(45)(46)(47)49,(51)(52)(53)(54)(55)57,59,61 ), the mean percentage changes (vs. baseline) in cholesterol, triglyceride, LDL-C, and HDL-C levels were -0.3, 2.3, -1.2, and 3.2%, respectively. Thus, about 10 g of olive oil per day had negligible effects on most lipoprotein fractions, with the possible exception of HDL-C.…”

Section: Human Studiesmentioning

confidence: 99%

n‐3 fatty acids and lipoproteins: Comparison of results from human and animal studies

Harris

1996

Lipids

236

153

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The impact of n-3 fatty acids (FA) on blood lipoprotein levels has been examined in many studies over the last 15 yr in both animals and humans. Studies in humans first demonstrated the potent triglyceride-lowering effect of n-3 FA, and these were followed up with animal studies to unravel the mechanism of action. This paper reviews the reported effects of n-3 FA on blood lipoproteins in 72 placebo-controlled human trials, at least 2 wk in length and providing 7 or less g of n-3 FA/day. Trials in normolipidemic subjects (triglycerides < 2.0 mM; 177 mg/dL) were compared to those in hypertriglyceridemic patients (triglycerides > or = 2.0 mM). In the healthy subjects, mean triglyceride levels decreased by 25% (P < 0.0001), and total cholesterol (C) levels increased by 2% (P < 0.009) due to the combined increases in low density lipoprotein (LDL)-C (4%, P < 0.02) and high density lipoprotein (HDL)-C (3%, P < 0.008). In the patients, triglyceride levels decreased by 28% (P < 0.0001), LDL-C rose by 7% (P < 0.0001), but neither total C nor HDL-C changed significantly. Although the effect on triglyceride levels is also observed in rats and swine, it is rarely seen in mice, rabbits, monkeys, dogs, and hamsters. Whereas n-3 FA have only a minor impact on lipoprotein C levels in humans, they often markedly lower both total C and HDL-C levels in animals, especially monkeys. These differences are not widely appreciated and must be taken into account when studying the effects of n-3 FA on lipoprotein metabolism.

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“…This is consistent with the observation of a detectable (remaining) amount of /3-VLDL on agarose gel electrophoresis after supplementation and agrees with results from an earlier report. 35 The relative proportion of /3-to pre-/3-VLDL depends on the equilibrium between the rates of VLDL and chylomicron production, on their ability to be lipolyzed, and finally on their uptake by the liver. 36 Potentially, fish oils may alter any or all of these pathways, which may explain the heterogeneity of the response.…”

mentioning

confidence: 99%

Fish oil supplementation reduces beta-very low density lipoprotein in type III dysbetalipoproteinemia.

Dallongeville

Boulet

Davignon

et al. 1991

Arterioscler Thromb

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0-Very low density lipoproteins (^J-VLDLs) are atherogenic, cholesterol-rich chylomicron and VLDL remnants that accumulate in the plasma of type III dysbetalipoproteinemic subjects. To evaluate the effect offish oil supplementation on plasma /3-VLDL concentrations, we compared the lipid and lipoprotein responses in nine type III and nine type IV hyperlipidemic subjects. Each individual received 6 g/day o>-3 fatty acids for 12 weeks. Before treatment, the mean total cholesterol, total triglyceride, VLDL triglyceride, low density lipoprotein (LDL) cholesterol, and high density lipoprotein (HDL) cholesterol levels were not different between groups. Conversely, VLDL cholesterol, intermediate density lipoprotein (IDL) cholesterol, and IDL triglycerides were higher in type III than in type IV subjects. Fish oil supplementation was associated with significantly lower levels of cholesterol (-50%), triglycerides (-50%), and apolipoprotein B (-50%) in the d< 1.006 g/ml ultracentrifugation plasma fraction in both groups, compatible with a reduction in VLDL in type III and type IV subjects, and in /3-VLDL in type III subjects. This finding was confirmed by analysis of the plasma zonal ultracentrifugation profile and the agarose gel electrophoretic pattern of lipoproteins, which showed a reduction in but not a disappearance of remnant particles, suggesting that not all /3-VLDL had been cleared after treatment. The levels of IDL cholesterol and IDL triglycerides (1.006

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Effect of fish oil treatment on plasma lipoproteins in type III hyperlipoproteinaemia

Cited by 24 publications

References 18 publications

Manipulation of then-3 polyunsaturated fatty acid composition of avian eggs and meat

Manipulation of then-3 polyunsaturated fatty acid composition of avian eggs and meat

n‐3 fatty acids and lipoproteins: Comparison of results from human and animal studies

Fish oil supplementation reduces beta-very low density lipoprotein in type III dysbetalipoproteinemia.

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