Effect of flavonol glycoside in mulberry (<i>Morus alba</i> L.) leaf on glucose metabolism and oxidative stress in liver in diet‐induced obese mice

Katšube, Takao; Yamasaki, Masayuki; Shiwaku, Kuninori; Ishijima, Tomoko; Matsumoto, Ichiro; Abe, Keiko; Yamasaki, Yukikazu

doi:10.1002/jsfa.4096

Cited by 82 publications

(65 citation statements)

References 27 publications

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“…For instance, chlorogenic acid is known to be a strong antioxidant and it is also known to reduce plasma glucose in humans (Iwai et al 2012). Similarly, quercetin-3-6-malonylglucoside has been reported to be highly bioactive and known to be effective against oxidation of low-density lipoprotein and oxidative stress in the liver (Katsube et al 2010). Extracts of black currant leaves have been demonstrated to possess anti-inflammatory and anti-virus activities (Tabart et al 2011;Ehrhardt et al 2013).…”

Section: Discussionmentioning

confidence: 99%

Phenolic compounds in black currant leaves – an interaction between the plant and foliar diseases?

Vagiri

Johansson

Rumpunen

2017

Journal of Plant Interactions

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Interactions between phenolic compounds in black currant leaves and foliar diseases may be important in breeding for resistant genotypes with a nutritional high profile for human applications. For increased understanding of such interactions, we evaluated the presence of major fungal diseases by visual inspection, and content of phenolic compounds by HPLC in leaves of five segregating black currant breeding populations. Eight individual flavonols (e.g. quercetin-3-Oglucoside, quercetin-3-O-rutinoside and kaempferol-malonylgucoside), three flavan-3-ols (epigallocatechin, catechin and epicatechin) and two chlorogenic acids (neochlorogenic acid and chlorogenic acid) were significantly correlated to the leaf diseases. Rib-0701 was the population possessing the highest content for several of the compounds, while genotype differences existed for content of various phenolic compounds and resistance to the diseases. The high variability of content of phenolic compounds opens up for opportunities to breed resistant genotypes with improved health properties of the leaves for functional food products. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 99%

Phenolic compounds in black currant leaves – an interaction between the plant and foliar diseases?

Vagiri

Johansson

Rumpunen

2017

Journal of Plant Interactions

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“…Previously, we reported that quercetin 3-(6-malonyglucoside) is the major flavonol glycoside in mulberry leaves, and that it has a strong antioxidant effect (Katsube et al, 2006). We also reported that it altered blood glucose levels via a mechanism different from that of 1-deoxynojirimycin (DNJ) (Katsube et al, 2010). Our research group reported that chlorogenic acid, an abundant polyphenol in mulberry leaves, plays an important role in the antioxidant activity of leaf extracts (Katsube et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Seasonal Changes in Functional Component Contents in Mulberry (<i>Morus alba</i> L.) Leaves

Sugiyama

Katšube²,

Kôyama³

et al. 2017

The Hortic J

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The aim of this study was to determine the best time to harvest mulberry (Morus alba L.) leaves for optimal yields of functional components. Mulberry leaves were analyzed to determine the seasonal changes in the concentrations of functional components, including flavonols, chlorogenic acid, and 1-deoxynojirimycine (DNJ). During the experimental period (May 26-October 16), the ranges of flavonols, chlorogenic acid, and DNJ contents were 1134-2230 mg/100 g dry weight (DW), 616-1014 mg/100 g DW, and 53-199 mg/100 g DW, respectively. There were high flavonols contents in mulberry leaves from late May to early July, from early to mid-August, and after late September. There were high chlorogenic acid contents from late May to early July, and after late September. From late September, the flavonols contents increased over time, and showed the highest level on October 16, the last day of the experimental period. The increased flavonols contents after late September were due to the synergistic effects of solar radiation and lower temperatures. The DNJ content showed a bell-shaped curve, peaking in mid-August, and the DNJ content was strongly correlated with total temperature. The flavonols and chlorogenic acid contents in mulberry leaves were higher after late September when the temperatures decreased and there was still high solar radiation, while the DNJ content peaked in August when temperatures were highest. The results indicated that August is the best time to harvest mulberry leaves to obtain optimal yields of beneficial functional components. If mulberry leaves are harvested twice per year, then the first harvest should be in July to August when temperatures and solar radiation hours are high, and the second harvest should be completed by the end of September.

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“…According to the Dong-eui-bo-gam, the oldest Korean medicinal book, Morus alba leaf (MAL), also known as Mori folium when used as a herbal medicine, alleviates the symptoms of beriberi, body swelling, dropsy and diabetes (1). Modern medical studies of the leaves of the white mulberry have reported anti-atherogenic (2), anti-hypertensive (3,4), anti-obesity (5), anti-diabetic (6) and liver protective (7,8) effects.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant activities and polyphenol content of Morus alba leaf extracts collected from varying regions

et al. 2014

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Abstract. Morus alba leaf (MAL), also known as Mori folium when used as a herbal medicine, has traditionally been used in Chinese medicine to treat diabetes, protect the liver and lower blood pressure. In the present study, MAL was collected from various regions in Korea and the antioxidant activity, total polyphenol contents and main flavonoid contents was investigated. MAL were collected from various areas in Korea and extracted with methanol. The total polyphenol contents were evaluated based on the Folin-Ciocalteu method using a spectrophotometer. The antioxidant activities were determined by a 2,2-diphenyl-1-picrylhydrazyl radical scavenging assay method. The identification and quantification of three main polyphenol constituents was performed using high-performance liquid chromatography/diode array detection analysis. The total polyphenol contents of the MAL extracts varied between 23.2 and 55.4 mg gallic acid equivalent/g. The radical scavenging activity (SC 50 ) of the MAL extracts ranged between 584 and 139 µg/ml. Three flavonol compounds (rutin, isoquercitrin and astragalin) were identified as main polyphenol constituents. These contents varied from 0.68-12.7, 0.69-9.86 and 0.05-3.55 mg/g, respectively. The average of the total was 9.52 mg/g, which was similar to that of commercial MAL extracts (10.58 mg/g). Among the three flavonol compounds, isoquercitrin showed the highest content (5.68 mg/g) followed by rutin (3.1 mg/g) and astragalin (2.4 mg/g). In the present study, the radical scavenging activity, polyphenol content and flavonol content of MAL were significantly different according to growing area. These three flavonol compounds were identified as main constituents of MAL in this study, and are known to have various biological activities, as well as strong antioxidant activities. Therefore, the sum of these three flavonol compounds was indicated as a good marker for the quality control of Mori folium.

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Effect of flavonol glycoside in mulberry (Morus alba L.) leaf on glucose metabolism and oxidative stress in liver in diet‐induced obese mice

Abstract: Dietary consumption of Q3MG, the quantitatively major flavonol glycoside in mulberry leaves, improved hyperglycemia in obese mice and reduced oxidative stress in the liver.

Cited by 82 publications

References 27 publications

Phenolic compounds in black currant leaves – an interaction between the plant and foliar diseases?

Phenolic compounds in black currant leaves – an interaction between the plant and foliar diseases?

Seasonal Changes in Functional Component Contents in Mulberry (<i>Morus alba</i> L.) Leaves

Antioxidant activities and polyphenol content of Morus alba leaf extracts collected from varying regions

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