Effect of flavonol glycosides from Cinnamomum osmophloeum leaves on adiponectin secretion and phosphorylation of insulin receptor-β in 3T3-L1 adipocytes

Lee, Meng-Jen; Rao, Yerra Koteswara; Chen, Keru; Lee, Yi‐Ching; Tzeng, Yew‐Min

doi:10.1016/j.jep.2009.08.006

Cited by 32 publications

(11 citation statements)

References 34 publications

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“…It was found that basal secretion was higher than the insulin-stimulated secretion, and this suggests that adiponectin secretion activity of hot aqueous extract was independent of insulin. The 500 μ g/mL of hot aqueous extract augments basal adiponectin secretion higher than 100 nM insulin indicating that the extract augments adiponectin secretion in an insulin-mimetic manner [78]. Meanwhile, 1000 μ g/mL of hot aqueous extract augments both basal and insulin-stimulated adiponectin secretion greater than that of 100 nM insulin suggesting that this extract enhances adiponectin secretion by mimicking and sensitizing insulin action.…”

Section: Discussionmentioning

confidence: 99%

Ficus deltoidea: A Potential Alternative Medicine for Diabetes Mellitus

Adam

Khamis

Ismail

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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Ficus deltoidea from the Moraceae family has been scientifically proven to reduce hyperglycemia at different prandial states. In this study, we evaluate the mechanisms that underlie antihyperglycemic action of Ficus deltoidea. The results had shown that hot aqueous extract of Ficus deltoidea stimulated insulin secretion significantly with the highest magnitude of stimulation was 7.31-fold (P < 0.001). The insulin secretory actions of the hot aqueous extract involved K+ ATP channel-dependent and K+ ATP-channel-independent pathway. The extract also has the ability to induce the usage of intracellular Ca2+ to trigger insulin release. The ethanolic and methanolic extracts enhanced basal and insulin-mediated glucose uptake into adipocytes cells. The extracts possess either insulin-mimetic or insulin-sensitizing property or combination of both properties during enhancing glucose uptake into such cells. Meanwhile, the hot aqueous and methanolic extracts augmented basal and insulin-stimulated adiponectin secretion from adipocytes cells. From this study, it is suggested that Ficus deltoidea has the potential to be developed as future oral antidiabetic agent.

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Section: Discussionmentioning

confidence: 99%

Ficus deltoidea: A Potential Alternative Medicine for Diabetes Mellitus

Adam

Khamis

Ismail

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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“…Although the constituents of Andrographis paniculata are reported to have anti-diabetic potency, the precise active compounds responsible for diabetic nephropathic activity of this plant have not been clearly identified. In the continuation of our search for the bioactive natural products (Rao et al, 2006Lee et al, 2009;Tzeng et al, 2009), we are intended to test how AP1 and its related compound AP2 from Andrographis paniculata act on high glucose afflicted renal cells. High blood glucose-induced advanced glycation end product and transforming growth factor (TGF)-␤ secretion of tubular cells, and subsequent fibronectin/extracellular matrix (ECM) deposition and cell death are proposed for the etiopathology of DN (Ayo et al, 1990;Ziyadeh et al, 1994;Oh et al, 1998;Ha and Lee, 2000).…”

Section: Introductionmentioning

confidence: 99%

Andrographolide and 14-deoxy-11,12-didehydroandrographolide from Andrographis paniculata attenuate high glucose-induced fibrosis and apoptosis in murine renal mesangeal cell lines

Lee

Rao

Chen

et al. 2010

Journal of Ethnopharmacology

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“…Recent studies have shown that several phytochemicals enhanced adiponectin production in adipocytes. [20][21][22][23][24] The objective of this study was to isolate new chalcones from A. keiskei and to evaluate their potential for producing adiponectin in 3T3-L1 adipocytes.…”

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confidence: 99%