Effect of flubendazole on the number of first-stage larvae of Angiostrongylus cantonensis released in the faeces of treated rats

Abstract

The effect of flubendazole orally administered at 10 mg/kg/day for 5 consecutive days (the 11th, 20th or 40th post-infection) on the number of first-stage larvae (L1) of Angiostrongylus cantonensis released in the faeces of rats each infected with 40 third-stage larvae was determined. Faecal examination for 5 months, the period from medication to dissection of rats, showed that L1 release ceased in all the rats of medicated groups by about 1 week after the termination of dosing and resumed 1–2 months later in 86% of the rats which were dissected at the end of experiments with the recovery of adult worms of both sexes. Throughout the period of 5 months, about 2–4×104 L1/gram of fresh faeces was recorded in non-medicated control groups. There was a 38–79% reduction in adult worms at the dissection. Microscopic examination of the uteri of the remaining adult worms and lung tissues of rats confirmed no normal egg production in the adult worms from rats of medicated groups, except the rats with the resumption of faecal L1 release.

Drug trials for treatment of human angiostrongyliasis

“…MAKI & YANAGISAWA 31 determined the effect of flubendazole po administered at 10 mg/kg/day for five consecutive days (the 11 th ; 20 th or 40 th post-infection) on the number of first-stage larvae of Angiostrongylus cantonensis, released in the faeces of rats. Faecal examination for five months showed that L1 release ceased one week after conclusion of treatment and resumed one to two months later in 86% of the rats.…”