Effect of fluoride dosage on human parotid saliva fluoride levels

Shannon, Ira L.; Edmonds, Eleanor J.

doi:10.1016/0003-9969(72)90163-x

Cited by 24 publications

(14 citation statements)

References 14 publications

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“…All of the study subjects were found to have resting salivary fluoride levels similar to those reported in non-fluoride areas by Shannon and Edmonds [1972]. Both inter-and intraindividual variations showed no statistically significant differences, although it was possible to distinguish slight non-statistically signifi cant variation in 2 individuals who were subsequently found to swallow toothpaste daily when brushing.…”

Section: Discussionmentioning

confidence: 63%

“…Five gelatin capsules of preweighed tooth paste (approximately 1.0 g toothpaste/capsule) were then swal lowed. This amount of toothpaste contributed close to 5.0 mg F. Five milligrams fluoride was given to enable comparison of data with other studies, including those of Ekstrand et al [1977] and Shannon and Edmonds [1972], where these amounts had also been given in adults.…”

Section: Methodsmentioning

confidence: 99%

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Estimation of Fluoride Absorption from Swallowed Fluoride Toothpastes

Drummond¹,

Curzon²,

Strong³

1990

Caries Res

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Eight adults ingested five different toothpastes with and without 1,000 ppm (1 μg/g) fluoride added as NaF or Na₂PO₃F. The systemic fluoride absorption was estimated by comparing the areas under salivary fluoride concentration curves produced after the toothpaste ingestion. Of the toothpastes investigated – chalk, dicalcium phosphate dihydrate, silica or alumina with sodium monofluorophosphate, and silica with sodium fluoride – the fluoride absorption was found to be statistically significantly lower only from the dicalcium phosphate dihydrate toothpaste. Measuring changing fluoride levels in saliva appears to be an acceptable non-invasive technique for following systemic fluoride absorption.

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Section: Discussionmentioning

confidence: 63%

Section: Methodsmentioning

confidence: 99%

Estimation of Fluoride Absorption from Swallowed Fluoride Toothpastes

Drummond¹,

Curzon²,

Strong³

1990

Caries Res

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“…If there was a change, it did not correlate with the change in plasma fluoride concentration. Indeed, the plasmaitear ratios changed from 0.67 at 1 ppm to 1.8 at 50 ppm, indicating that tear fluo ride levels increased at a much lesser rate than plasma levels when days 8 through 29 are considered (to allow a steady state to be achieved after manipulation of the fluoride level in the drinking water [3]). The plasma:tear ratios changed as follows: 1 ppm, 0.67; 5 ppm, 0.45; 10 ppm, 1.23; 25 ppm, 1.68; 50 ppm, 1.81.…”

Section: Resultsmentioning

confidence: 99%

“…Examinations have been made of the relationship between plasma and salivary concentrations [3][4][5][6] as well as with gingival crevicular fluid concentrations [7], These studies indicated that the acute ingestion of fluoride caused an increase in salivary fluo ride over a short (10-20 min) time period [3]. When longer-term ingestion occurred on a daily basis, no significant correlation ex isted between the fluoride concentration in saliva with that in plasma [3,4,8],…”

Section: Introductionmentioning

confidence: 99%

Relationship between Plasma and Tear Fluoride Levels in Rabbit and Man

Chan

Cheeks²,

Slagle³

et al. 1990

Ophthalmic Res

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Tear fluoride concentrations were determined in rabbits and man. Tear fluoride levels in reflex tears were higher in rabbits (2–10 µmol/l) than in man (1.4–4 µmol/l), while plasma levels were quite similar in both species (1.5–4 µmol/l). Chronic fluoride ingestion in rabbits over 29 days of 1, 5, 10, 25 or 50 (2.65 mmol/l) ppm fluoride in drinking water caused a dose-related increase in plasma, but not tear, levels of fluoride. The plasma:tear ratio went from 0.5 at baseline (1 ppm) to 1.8 after drinking water that contained 50 ppm F. Acute fluoride ingestion in man led to an increase in both plasma and tear fluoride levels that changed such that the plasmartear ratio remained constant despite a 2-fold increase in plasma fluoride.

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“…The protective role of saliva in the reversal or arrestment of the caries process is well established (Mandel andZengo, 1973, Shannon andEdmonds, 1972).…”

Section: The Role Of Salivamentioning

confidence: 99%