2012
DOI: 10.1007/s12011-012-9482-x
|View full text |Cite
|
Sign up to set email alerts
|

Effect of Fluoride on Insulin Level of Rats and Insulin Receptor Expression in the MC3T3-E1 Cells

Abstract: Studies on the role of insulin and insulin receptor (InsR) in the process of skeletal fluorosis, especially in osteogenic function, are rare. We evaluated the effect of increasing F⁻ doses on the marker of bone formation, serum insulin level and pancreatic secretion changes in vivo and mRNA expression of InsR and osteocalcin (OCN) in vitro. Wistar rats (n = 50) were divided into two groups, i.e. a control group and fluoride group. The fluoride groups were treated with fluoride by drinking tap water containing … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
11
0

Year Published

2014
2014
2023
2023

Publication Types

Select...
5
5

Relationship

0
10

Authors

Journals

citations
Cited by 22 publications
(11 citation statements)
references
References 19 publications
0
11
0
Order By: Relevance
“…Interestingly, fluoride expedites the mRNA expression of insulin receptor (InsR) in vitro. A close and inverse relationship exists between insulin secretion and blood fluoride level [41]. So, excess fluoride exposure might be a silent cause of recent worldwide rise in diabetic population (Table 1).…”
Section: Medical and Clinical Reviews Issn 2471-299xmentioning
confidence: 99%
“…Interestingly, fluoride expedites the mRNA expression of insulin receptor (InsR) in vitro. A close and inverse relationship exists between insulin secretion and blood fluoride level [41]. So, excess fluoride exposure might be a silent cause of recent worldwide rise in diabetic population (Table 1).…”
Section: Medical and Clinical Reviews Issn 2471-299xmentioning
confidence: 99%
“…A significant effect of F on OC expression has been found to occur in adults at serum F levels of 1.0 μM [154] or when urinary F levels exceed 0.62 mg/L in adolescent children [155]. Consistent with this data, several in-vivo studies have reported that chronic F exposure enhances plasma insulin levels and promotes insulin resistance in rodents [211,212,213,214,215]. A similar association has also been found in humans chronically exposed to F [216].…”
Section: Molecular Mechanisms Of Fluoride Inhibition Of Iodine Hommentioning
confidence: 77%
“…Conversely, Lombarte et al (2013) demonstrated that in rats given NaF (15 mg/l) in drinking water there was a significant plasma increase in glucose level and insulin resistance. Others have shown an increase of serum insulin and a decrease of serum glucagon in rats treated with NaF (100 mg F/1 l) for 1 year (Hu et al 2012). Summarizing, fluoride affects glucose and insulin levels in a dose and time dependent fashion—an increase or decrease can be observed.…”
Section: Discussionmentioning
confidence: 98%