Effect of fluoride sustained slow-releasing device on fluoride, phosphate and calcium levels in plaque biofilms over time measured using ion chromatography

Abudiak, Hani; Robinson, C.; Duggal, M. S.; Strafford, S.; Toumba, K. J.

doi:10.1016/j.jdent.2012.04.008

Cited by 5 publications

(9 citation statements)

References 32 publications

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“…These findings were higher at baseline but lower after 3 months with baseline levels of 0.014 ± 0.02 ppm, whereas after 1 month, levels increased to 0.62 ± 1.00 ppm (Kapetania et al, ). The present studys findings appeared to be higher compared with the results after 7 days (0.057 ± 0.019 ppm F) and after 21 days (0.047 ± 0.028 ppm F) in a similar study (Abudiak et al, ). Because the chemical preparation of the samples was identical, the only possible explanation for the differences apart from the fact that the samples were not obtained at identical time points was the use of a different eluent in the IC.…”

Section: Discussioncontrasting

confidence: 58%

“…In this study, the chemical preparation of the saliva sample was identical to previous studies (Abudiak et al, ; Benzo et al, ). The retention time of the F peak was not consistent, and in many cases, there were competing peaks from other ions appearing very close to the F peak; hence, the peak of interest was not identifiable.…”

Section: Discussionmentioning

confidence: 82%

“…In a study investigating blood plasma, it was reported that the separation columns original characteristics did not change; however, they concluded: "scarce information has been given about column integrity after this type of analysis". (Abudiak, Robinson, T A B L E 1 F (ppm) in whole unstimulated saliva in n = 10 volunteers with fluoride slow-release glass devices (Benzo et al, 2002) has been used to analyse F in human saliva (Abudiak et al, 2012;Kapetania et al, 2005).…”

Section: Ion Chromatographymentioning

confidence: 99%

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Effect of fluoride slow‐release glass devices on salivary and gingival crevicular fluid levels of fluoride: A pilot study

Tatsi

Toumba

2019

Clinical & Exp Dental Res

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ObjectivesTo estimate the effect of fluoride slow‐release glass devices on the levels of fluoride in a pooled sample of human gingival crevicular fluid and in human saliva.Materials and MethodsTen healthy adult volunteers wore fluoride slow‐release glass devices for 3 months in a longitudinal experimental clinical pilot study. Whole unstimulated human saliva and gingival crevicular fluid were collected using paper points at baseline, after 2 weeks and at 3 months and analysed for their fluoride levels using ion chromatography and fluoride electrode.ResultsNo adverse effects were reported, and the Löe Plaque and Gingival Index remained low (0.22). The saliva determination of fluoride using the fluoride electrode showed an increase after 3 months from 0.02 ± 0.04 ppm to 0.06 ± 0.12 ppm, whereas the ion chromatography showed an increase from 0.15 ± 0.10 ppm to 0.44 ± 0.36 ppm. The fluoride levels in a pooled sample of gingival crevicular fluid from four intraoral sites were determined using the ion chromatography, and the results showed that after 3 months, the fluoride levels were still low (0.71 ± 0.34 ppb) similar to those at baseline (0.74 ± 0.31 ppb).ConclusionsThe fluoride concentration in a pooled sample of gingival crevicular fluid was reported to be low with a range from 0.46 to 0.75 ppb and was not changed by placement of fluoride slow‐release glass devices. The fluoride concentration in unstimulated human saliva showed an increase after 3 months when the fluoride slow‐release glass devices were attached when determined with both the fluoride electrode (from .02 ± 0.04 ppm to 0.06 ± 0.12 ppm) and ion chromatography (from 0.15 ± 0.10 ppm to 0.44 ± 0.36 ppm).

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Section: Discussioncontrasting

confidence: 58%

Section: Discussionmentioning

confidence: 82%

Section: Ion Chromatographymentioning

confidence: 99%

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Effect of fluoride slow‐release glass devices on salivary and gingival crevicular fluid levels of fluoride: A pilot study

Tatsi

Toumba

2019

Clinical & Exp Dental Res

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“…The environmental and health authorities, as well as modern industrial technologies impose stringer and stringer demands to the water quality and methods for determination at trace levels are highly demanded [5][6][7][8][9]. Ion chromatography appears to be widely studied method for anion determination which successfully addressed this issue [1,2,[7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

“…A line of studies on optimisation and validation of ion chromatographic methods for anions determination have been recently published [7][8][9][10][11][12][13]. The validation procedure was profoundly described in the international legislation to ensure comparable laboratory results [14][15][16][17].The validation should prove that the results obtained by given laboratory were not significantly different from the reference results [16,17].Validation of a method for chloride, nitrate and sulphate ions determination in drinking water was reported [12]; all contributions involved in the analysis were considered in estimation of the uncertainty.…”

Section: Introductionmentioning

confidence: 99%

Validation of Ion Chromatographic Method for Determination of Standard Inorganic Anions in Treated and Untreated Drinking Water

Ivanova

Surleva

Koleva³

2018

IOP Conf. Ser.: Mater. Sci. Eng.

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Abstract. An ion chromatographic method for determination of fluoride, chloride, nitrate and sulphate in untreated and treated drinking waters was described. An automated 850 IC Professional, Metrohm system equipped with conductivity detector and Metrosep A Supp 7-250 (250 x 4 mm) column was used. The validation of the method was performed for simultaneous determination of all studied analytes and the results have showed that the validated method fits the requirements of the current water legislation. The main analytical characteristics were estimated for each of studied analytes: limits of detection, limits of quantification, working and linear ranges, repeatability and intermediate precision, recovery. The trueness of the method was estimated by analysis of certified reference material for soft drinking water. Recovery test was performed on spiked drinking water samples. An uncertainty was estimated. The method was applied for analysis of drinking waters before and after chlorination.

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Intraoral medical devices for sustained drug delivery

Alghanem,

Dziurkowska,

Ordyniec-Kwaśnica

et al. 2023

Clin Oral Invest

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Objectives The oral cavity constitutes an attractive organ for the local and systemic application of drug substances. Oromucosal tablets, gels, or sprays are examples of the formulations applied. Due to the elution through the saliva, the residence time of the formulation at the application site is relatively short. Medical devices placed in the oral cavity, with a reservoir for an active substance, play an important role in solving this problem. Materials and methods In this review, we discuss the devices described in the literature that are designed to be used in the oral cavity, highlighting the advantages, disadvantages, and clinical applications of each of them. Results Among the intraoral medical devices, special types are personalized 3D-printed devices, iontophoretic devices, and microneedle patches. Conclusion We anticipate that with the development of 3D printing and new polymers, the technology of flexible and comfortable devices for prolonged drug delivery in the oral cavity will develop intensively. Clinical relevance The presented review is therefore a useful summary of the current technological state, when in fact none of the existing devices has been widely accepted clinically.

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Effect of fluoride sustained slow-releasing device on fluoride, phosphate and calcium levels in plaque biofilms over time measured using ion chromatography

Cited by 5 publications

References 32 publications

Effect of fluoride slow‐release glass devices on salivary and gingival crevicular fluid levels of fluoride: A pilot study

Effect of fluoride slow‐release glass devices on salivary and gingival crevicular fluid levels of fluoride: A pilot study

Validation of Ion Chromatographic Method for Determination of Standard Inorganic Anions in Treated and Untreated Drinking Water

Intraoral medical devices for sustained drug delivery

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