Effect of Fluorosis on Hepatic Enzymes in Human

Abstract

Fluorosis is a major public health problem in India. This cross-sectional observational study has been conducted in the fluoride endemic zones of Bankura district to evaluate the effect of fluorosis on the liver enzymes. This study was carried out in the Simlapal block of Bankura, on 100 subjects by using simple random sampling in which 50 were cases. The serum samples were collected from the subjects and serum fluoride was estimated by Ion-Meter and serum ALT, AST, ALP and LDH levels were determined by auto-analyzer and were compared with age and sex matched controls. The serum fluoride was found to have a statistically significant relationship with AST and ALP and serum LDH has also statistically significant relationship with ALT and AST in the study group. The serum levels of fluoride, ALT, AST, ALP and LDH were higher in the study group compared to the comparison group.

Effect of Moringaoleifera Lam. on haematological and histopathological parameters in sodium flouride induced toxicity in wistar rats

“…Fluoride causes damage not only to hard tissues of teeth and skeleton (Grynpas, 1990; WHO, 2002) but also to soft tissues, such as brain, liver, kidney, spleen and endocrine glands (WHO, 1984;Shanthakumari et al, 2004;Shashi and Thapar, 2001;Shashi et al, 2002;Zhan, 2006). Fluoride induced hepatotoxicity due to the formation of free radicals and decreased activity of the antioxidant system in hepatocytes of animals and humans have been reported (Chatterjee et al, 2016;Guo et al, 2003). Fluoride exposure also induces histopathological changes in liver involving focal necrosis, infiltration of leucocytes, swelling of kupffer cells, extensive vacuolization, hemorrhagic areas, ultrastructural alterations in hepatocytes and increased apoptosis in animals and humans (Chinoy et al, 2004;Basha and Rao, 2014).…”

Molecular Mechanism of Changes in Gene Expression of Cytosolic Cu/Zn SOD, Lipid Peroxidation and Hepatic Function Impairments during Experimental Fluorosis

“…A similar investigation was conducted by some workers on rats [44]. The previous study has demonstrated a significant positive relationship between serum fluoride level and activities of ALT, AST, ALP and LDH in population of fluoride endemic area [14,45]. Mitta et al [46] reported an abnormal increase in the concentrations of aminotransferases and serum ALP level indicate the disruptive functions of the liver in rats given 100 mg NaF for four weeks.…”

Effect of drinking high fluoride water on liver enzymes a comparitive cross-sectional study

“…A study done by Shashi in India among regions where fluorosis was endemic in 2011 also identified changes in liver enzymes, with alkaline phosphatase levels increasing in correlation with serum fluoride levels while AST and ALT were found higher in females affected from fluorosis [20]. Similarly in 2016, a study carried by Suman Chatterjee on the Indian inhabitant living in fluorosis area has also shown the elevated liver enzyme activity among subjects with fluorosis [21]. The observed findings were statistically significant in regards to impairment of gamma GT and Alkaline phosphatase, it is valuable highlighting that the divergent range was not demarcated in the study.…”