Effect of fluoxetine at different concentrations on the adsorption behavior of Langmuir monolayers

Xie, Bin; Hao, Changchun; Sun, Run‐Cang

doi:10.1016/j.bbamem.2020.183418

Cited by 6 publications

(2 citation statements)

References 34 publications

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“…The principal difference is that for the second type of experiment, the collapse pressure decreases from 49.41 mN m −1 for pure DSPA to 31.1 mN m −1 . This important decrease can be attributed to the fact that the incorporation of the cationic drug into the film decreases the stability of the monolayer, anticipating the 2D–3D process, as previously reported for other pharmaceutical drugs, such as ibuprofen [ 28 ], paclitaxel [ 35 ] and fluoxetine [ 36 ]. These results also reinforce what was previously mentioned above, that part of DSPA molecules was expelled from the monolayer at higher surface pressure, as represented in Scheme 2 a right.…”

Section: Discussionsupporting

confidence: 66%

Interaction between Pharmaceutical Drugs and Polymer-Coated Fe3O4 Magnetic Nanoparticles with Langmuir Monolayers as Cellular Membrane Models

2023

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Surface modification of magnetic nanoparticles (MNPs) has been reported to play a significant role in determining their interactions with cell membranes. In this research, the interactions between polymer functionalized (chitosan, CHI or diethylamino-ethyl dextran, DEAE-D) Fe3O4 MNPs, pharmaceutical drugs and model cell membranes were investigated by Langmuir isotherms and adsorption measurements. In this study, 1,2-distearoyl-sn-glycerol-3-phosphate (DSPA) phospholipid monolayers were used as cell membrane models. Insertion experiments demonstrate that diclofenac (DCFN) is not absorbed at the air–water interface, whereas triflupromazine (TFPZ) has a MIP (maximum insertion pressure) of 35 m Nm−1. The insertion of composites MNPs:TFPZ or DCFN has larger MIP values, indicating that the MNPs are adsorbed on the monolayer with the drugs. An Fe3O4@CHI:DCFN composite presented an MIP of 39 m Nm−1 and Fe3O4@DEAE-D:DCFN presented an impressive MIP of 67 mNm−1. In the case of TFPZ, the enhancement in the MIP values is also evident, being 42 mNm−1 for Fe3O4@CHI:TFPZ and 40 mNm−1 for Fe3O4@DEAE-D:DCFN composite. All MNPs:drugs composites have MIP values greater than commonly accepted membrane pressure values, indicating that MNPs:drugs can penetrate a cellular membrane. The fact that the composite MNPs:drugs present greater MIP values than separated compounds indicates that polymer-coated MNPs can act as good drug delivery systems.

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Section: Discussionsupporting

confidence: 66%

Interaction between Pharmaceutical Drugs and Polymer-Coated Fe3O4 Magnetic Nanoparticles with Langmuir Monolayers as Cellular Membrane Models

2023

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“…Antidepressant Amitriptyline [318], Fluoxetine [319,320], Thioridazine [321], Sertraline [199], Bupropion [199], Imipramine [199] Antipsychotic Clozapine [318,322], Haloperidol [322], Promazine [199], Chlorpromazine [199], Olanzapine [199], Alprazolam [199],…”

Section: Application and Target Drugs And Pharmaceuticsmentioning

confidence: 99%

Mechanistic Understanding from Molecular Dynamics in Pharmaceutical Research 2: Lipid Membrane in Drug Design

2021

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We review the use of molecular dynamics (MD) simulation as a drug design tool in the context of the role that the lipid membrane can play in drug action, i.e., the interaction between candidate drug molecules and lipid membranes. In the standard “lock and key” paradigm, only the interaction between the drug and a specific active site of a specific protein is considered; the environment in which the drug acts is, from a biophysical perspective, far more complex than this. The possible mechanisms though which a drug can be designed to tinker with physiological processes are significantly broader than merely fitting to a single active site of a single protein. In this paper, we focus on the role of the lipid membrane, arguably the most important element outside the proteins themselves, as a case study. We discuss work that has been carried out, using MD simulation, concerning the transfection of drugs through membranes that act as biological barriers in the path of the drugs, the behavior of drug molecules within membranes, how their collective behavior can affect the structure and properties of the membrane and, finally, the role lipid membranes, to which the vast majority of drug target proteins are associated, can play in mediating the interaction between drug and target protein. This review paper is the second in a two-part series covering MD simulation as a tool in pharmaceutical research; both are designed as pedagogical review papers aimed at both pharmaceutical scientists interested in exploring how the tool of MD simulation can be applied to their research and computational scientists interested in exploring the possibility of a pharmaceutical context for their research.

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The impact of fluoxetine and pH values on relaxation of the ternary lipid monolayers

Xie¹,

Hao

Sun

2021

Biochimica et Biophysica Acta (BBA) - Biomembranes

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Effect of fluoxetine at different concentrations on the adsorption behavior of Langmuir monolayers

Cited by 6 publications

References 34 publications

Interaction between Pharmaceutical Drugs and Polymer-Coated Fe3O4 Magnetic Nanoparticles with Langmuir Monolayers as Cellular Membrane Models

Interaction between Pharmaceutical Drugs and Polymer-Coated Fe3O4 Magnetic Nanoparticles with Langmuir Monolayers as Cellular Membrane Models

Mechanistic Understanding from Molecular Dynamics in Pharmaceutical Research 2: Lipid Membrane in Drug Design

The impact of fluoxetine and pH values on relaxation of the ternary lipid monolayers

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