Effect of fluoxetine on the testes of adult albino rats and the possible protective role of curcumin

Elsedawi, Basma Fathi; Hussein, Youssef; Sabry, Mohamed; Aziz, Joseph Amin

doi:10.1007/s12565-020-00573-9

Cited by 8 publications

(4 citation statements)

References 48 publications

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“…Elsedawi 21 conducted a study that validated this finding by demonstrating that fluoxetine can inhibit steroidogenesis by blocking serotonin reuptake and decrease the release of LH from the anterior pituitary lobe.…”

Section: Discussionmentioning

confidence: 89%

Moringa Oleifera mitigates the Fluoxetine-induced damage to the histological architecture of the seminiferous tubules in adult male rats

Ayesha Ali,

Abdullah Qamar,

Maimoona Khan

et al. 2024

Ann Pak Inst Med Sci

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Objective: To observe the ameliorative changes of Moringa oleifera on the gross and histological architecture of fluoxetine-treated adult rat testis. Methodology: This experimental study was conducted in Department of Anatomy, Army Medical College, Rawalpindi in collaboration with the National Institute of Health (NIH), Islamabad and Pathology Lab Pak Emirates Military Hospital Rawalpindi, Pakistan, from October 22 to April 2023. Thirty male Sprague Dawley rats were randomly divided into three groups (n=10). Rats were kept at the animal house of NIH Islamabad. Group A (control), Groups B and C (experimental) were given doses dissolved in distilled water through oral gavage once daily. The experimental period was 08 weeks. Group B was administered fluoxetine in a dose of 10 mg/kg body weight. Group C rats were treated with two chemicals, same dose of fluoxetine as in group B and concomitantly received 50 mg/30 grams body weight of Moringa Oleifera. After dissection, testes were fixed and staining was done with Hematoxylin & Eosin for histological study. Analysis of data was done on SPSS version 22. A p-value ? 0.05 was considered statistically significant. Results: The present study concluded that amelioration caused by Moringa Oleifera was statistically significant (p-value ?0.05) when compared to the other groups. Conclusion: Moringa Oleifera has ameliorative effects on the testicular toxicity induced by Fluoxetine in male rats by showing improvement in the diameter of the seminiferous tubules.

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Section: Discussionmentioning

confidence: 89%

Moringa Oleifera mitigates the Fluoxetine-induced damage to the histological architecture of the seminiferous tubules in adult male rats

Ayesha Ali,

Abdullah Qamar,

Maimoona Khan

et al. 2024

Ann Pak Inst Med Sci

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“…In the current study, the administration of adult rats with 10 mg/kg BW of fluoxetine for 28 days resulted in structural changes in the seminiferous tubules, including Small sized tubules with widening of peritubular sheath (PS).These results were proved by significant decrease in the diameter of the tubules ,Distorted spermatogenic epithelium with pyknotic and fragmented nuclei, loss of mature sperm from the lumen of some tubules, Separation of adluminal compartment of tubule from basal compartment with subsequent sloughing of germinal epithelium into tubular lumen were also detected on light microscopic examination of group II and were confirmed by electron microscope. Abdalmuhaimn et al [22] , reported considerable reduction in the thickness of its germinal epithelium and the width of its seminiferous tubules. Seminiferous tubules showed signs of deformation, as well as an almost empty lumen and decreased germinal layer.…”

Section: Discussionmentioning

confidence: 99%

Histological Protective Effect of Wheat Germ Oil Versus Zinc on Fluoxetine –Damaged Testes in Albino Rats

Fawzy,

Mahmoud

2023

Ain Shams Medical Journal

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Background: Fluoxetine is anti-depressive drug which induces oxidative stress in different organs, Wheat germ oil and zinc have antiinflammatory and antioxidant effects.Aim of the Study: to assess the histological effect of wheat germ oil (WGO) versus zinc on fluoxetine induced testicular injury in albino rats.Material & Methods: forty male albino rats were divided into four equal groups: group I (Control); group II: were received 10 mg/kg fluoxetine for 28 days; group III: administered fluoxetine + WGO at dose of 68.75 mg/kg; group IV: were received fluoxetine + zinc aspartate at dose of 30 mg/kg. samples of the testes were exposed to histological, ultrastructural and immunostaining examination.Results: fluoxetine significantly altered testicular structure. The seminefrous tubules were widely separated with significant decrease in their diameter. Separation of basal compartment of seminefrous tubules from adluminal compartment with cellular loss. This was confirmed by significant increase in Bax immunostaining. Widening of interstitial space with collagen fiber deposition was noticed. There was improvement of all histological aspects in WGO and zinc treated groups. This improvement was more evident in WGO treated group. The results were confirmed by significant increase in tubular diameter with more or less normal epithelial lining. Significant decrease in Bax immunoreaction was detected. Interstial tissue was normal .These data conclude that WGO augments the protection against fluoxetine induced testicular damage. Conclusion: fluoxetine induced oxidative damage in rat testis. We concluded that both WGO and zinc have protective role in ameliorating fluoxetine -associated testicular injury. However, WGO has better effects on all aspects.

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“…The effects of fluoxetine on the male reproduction have also been examined. Fluoxetine treatment in rat causes significant decrease in the body and testicular weight, activities of antioxidant enzymes, level of serum testosterone, while significant increase in lipid peroxidation in the organ [20,21]. However, other authors [22,23] have reported no alterations in the weight and histopathology of the testis, and in the level of serum testosterone.…”

Section: Centralmentioning

confidence: 99%

Antidepressant-Induced Testicular Alterations in the Normal and Depressed Mice

Kumar,

Tripathi,

Singh

2024

JSM Sexual Med

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Effect of fluoxetine on the testes of adult albino rats and the possible protective role of curcumin

Cited by 8 publications

References 48 publications

Moringa Oleifera mitigates the Fluoxetine-induced damage to the histological architecture of the seminiferous tubules in adult male rats

Moringa Oleifera mitigates the Fluoxetine-induced damage to the histological architecture of the seminiferous tubules in adult male rats

Histological Protective Effect of Wheat Germ Oil Versus Zinc on Fluoxetine –Damaged Testes in Albino Rats

Antidepressant-Induced Testicular Alterations in the Normal and Depressed Mice

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