Effect of flurbiprofen, metoclopramide and droperidol for nausea and emesis during cesarean section under spinal anesthesia

Kimura, Masafumi; Okamoto, Tomonori; Tsukagoshi, Hiroshi; Sato, Jun; Saito, Shigeru

doi:10.1007/s00540-011-1203-7

Cited by 4 publications

(1 citation statement)

References 20 publications

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“…Current studies have suggested that non-steroidal drugs positively affect UCP [14]. For example, flurbiprofen axetil is a non-selective non-steroidal drug, and it is safe for females who are breastfeeding in the early postpartum period [15,16]; thus, it is also safe for cesarean section analgesia.…”

Section: Introductionmentioning

confidence: 99%

Analgesic outcomes of tramadol alone and in combination with Butorphanol or Flurbiprofen Axetil after cesarean section: a retrospective study with propensity score matching analysis

Yang

Deng

et al. 2022

BMC Anesthesiol

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Background The Society for Obstetric Anesthesia and Perinatology recommends a multimodal analgesia regimen for cesarean delivery analgesia. This study aimed to compare the analgesic effects of tramadol alone and combined with butorphanol or flurbiprofen axetil after a cesarean section. Methods We performed a retrospective analysis based on the electronic medical records of a teaching hospital in China from January 2018 to January 2020. We collected data on demographic characteristics, anesthesia, analgesia strategy, and pain intensity postoperatively during the first 48 hours. Inadequate postoperative analgesia during this period was defined as an NRS score ≥ 4. We also collected data regarding off-bed activity and intestinal function recovery. Participants were classified into three groups according to analgesia regimens. Groups T, TF, and TB received tramadol, a mixture of tramadol and flurbiprofen axetil, and a combination of tramadol and butorphanol, respectively. Analgesic outcomes were compared using propensity score matching analysis. Results Data from 2323 cases of caesarean section were included in the analysis, and 521 pairs were matched in each group according to their propensity score. Compared with group T, The inadequate analgesia on pain at rest and pain at movement was lower in group TF (RR: 0.42, 95% CI: 0.36–0.49, P = 0.001 and RR: 0.58, 95% CI: 0.48–0.69, P < 0.001, respectively),and the incidence of inadequate control of pain at movement was higher in group TB (RR: 1.38, 95% CI: 1.22–1.55, P < 0.001). Additionally, the percentage of off-bed activity at 2 days postoperatively was higher in group TB than in groups TF and T (78.7% vs. 68.5 and 78.7% vs. 64.9%, respectively, P < 0.001). The incidence of intestinal function recovery 2 days after cesarean delivery in group TB was higher than that in group TF (73.3% vs. 66.2%, P = 0.013). Conclusions Combining tramadol and flurbiprofen axetil could enhance the analgesic effect and be safely used for analgesia after a cesarean section. However, combining tramadol and butorphanol may produce an antagonistic effect.

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Section: Introductionmentioning

confidence: 99%

Analgesic outcomes of tramadol alone and in combination with Butorphanol or Flurbiprofen Axetil after cesarean section: a retrospective study with propensity score matching analysis

Yang

Deng

et al. 2022

BMC Anesthesiol

View full text Add to dashboard Cite

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Interventions for preventing nausea and vomiting in women undergoing regional anaesthesia for caesarean section

Griffiths

Gyte

Popham

et al. 2021

Cochrane Database of Systematic Reviews

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Gastrointestinal inflammation plays a critical role in chemotherapy-induced nausea and vomiting

Chen

Zhao²,

Dai³

et al. 2022

European Journal of Pharmacology

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Effect of flurbiprofen, metoclopramide and droperidol for nausea and emesis during cesarean section under spinal anesthesia

Abstract: Intravenous flurbiprofen improves nausea and emesis after delivery by cesarean section more effectively than metoclopramide or droperidol.

Cited by 4 publications

References 20 publications

Analgesic outcomes of tramadol alone and in combination with Butorphanol or Flurbiprofen Axetil after cesarean section: a retrospective study with propensity score matching analysis

Analgesic outcomes of tramadol alone and in combination with Butorphanol or Flurbiprofen Axetil after cesarean section: a retrospective study with propensity score matching analysis

Interventions for preventing nausea and vomiting in women undergoing regional anaesthesia for caesarean section

Gastrointestinal inflammation plays a critical role in chemotherapy-induced nausea and vomiting

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