A field experiment was conducted during winter season of 2018-2019, at Al-Qurna district (75 km north of Basrah city centre). The aim of experiment was studding the effect of five levels of micronutrients (MN), Fe, Zn, Mn, Cu, B, and Mo: 0, 2 and 4 kg. ha-1 (soil application), 500 and 1000 ppm (foliar application), and three levels of activated yeast extract (AYE): 0, 3 and 6 g. L-1, in the yield and qualitative characteristics of wheat. The experiment was carried out using randomized completely block design in a split arrangement with three replicates. The main plots contained fertilizer levels. While the sub-plot occupied by Yeast levels. The results showed that spraying 1000 ppm from the solution of MN significantly increase the number of spikes per m2 , the number of grains in the spike, grain yield and biological yield with an increase by 15.4%, 18%, 27.5 % and 35% respectively compared to the control treatment, while the concentration of 500 ppm significantly increase protein yield with an increase of 35% compared to the control treatment. The results also showed that spraying 6 g. L- 1 of AYE differ significantly and gave the highest values of spikes number per m2 , number of grains per spike , grain yield , biological yield and protein yield, with an increase by 5.84%, 7.1%, 11.4% , 11.1% and 10.9% respectively compared to the control treatment. The interaction between application of 4 kg. MN ha-1 and the level of 6 g. L-1 AYE gave a significant superiority in the number of spikes (333.9 spike m-2), while the spraying of 1000 ppm + 6 g. L-1 AYE gave the highest grain yield (8.891 ton. ha-1) and biological yield (31.827 ton. ha-1).