A field experiment was carried out at Agricultural College farm, Bapatla district, Andhra Pradesh, during the period from March 2023 to June 2023 to assess the performance of Sesame (Sesamum indicum L.) varieties under different fertilizer management practices in rice-based cropping system in Krishna Zone of AP. The experiment was laid out in a randomized block design with the factorial concept and three replications. The results showed that YLM 146 recorded significantly the highest seed yield (748 kg ha-1) at harvest. The yield attributing characters like the number of capsules plant-1 (67) and the number of seeds capsules-1 (45) were found significantly to be the highest in the variety YLM 146. Concerning different fertilizer management practices, 125% RDF + 1% foliar spray of 19:19:19 at the early budding and capsule formation stages recorded significantly higher seed yields (827 kg ha-1). Yield attributes like number of capsules plant-1 (96) and number of seeds capsules-1 (51) were significantly highest in 125% RDF + 1% foliar spray of 19:19:19 at the early budding and capsule formation stages. Overall, the results showed that sowing of YLM 146 variety with 125% RDF + 1% foliar spray of 19:19:19 at the early budding stage and early capsule formation stage seems to be appropriate for getting higher seed yield in Krishna Zone of Andhra Pradesh.