Effect of Folic Acid Intake on Infant and Child Allergic Diseases: Systematic Review and Meta-Analysis

Chen, Zekun; Xing, Yan; Yu, Xue; Dou, Yuqi; Ma, Defu

doi:10.3389/fped.2020.615406

Cited by 13 publications

(9 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several studies have demonstrated that the continued FA supplementation after pregnancy may increase the risk of large-for-gestational-age birth [ 48 ], childhood asthma [ 49 ], childhood allergic [ 50 ], negative neurodevelopmental outcomes [ 51 , 52 ]. Thereby, we have an assumption that FA supplementation may not negatively but positively be associated with the risk of CHDs was consistent with the trend of CHD epidemic.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the association between maternal folic acid supplementation and the risk of congenital heart disease: a systematic review and meta-analysis

Cheng

Lian³

et al. 2022

Nutr J

View full text Add to dashboard Cite

Background Folic acid (FA), as a synthetic form of folate, has been widely used for dietary supplementation in pregnant women. The preventive effect of FA supplementation on the occurrence and recurrence of fetal neural tube defects (NTD) has been confirmed. Incidence of congenital heart diseases (CHD), however, has been parallelly increasing worldwide. The present study aimed to evaluate whether FA supplementation is associated with a decreased risk of CHD. Methods We searched the literature using PubMed, Web of Science and Google Scholar, for the peer-reviewed studies which reported CHD and FA and followed with a meta-analysis. The study-specific relative risks were used as summary statistics for the association between maternal FA supplementation and CHD risk. Cochran's Q and I2 statistics were used to test for the heterogeneity. Results Maternal FA supplementation was found to be associated with a decreased risk of CHD (OR = 0.82, 95% CI: 0.72–0.94). However, the heterogeneity of the association was high (P < 0.001, I2 = 92.7%). FA supplementation within 1 month before and after pregnancy correlated positively with CHD (OR 1.10, 95%CI 0.99–1.23), and high-dose FA intake is positively associated with atrial septal defect (OR 1.23, 95%CI 0.64–2.34). Pregnant women with irrational FA use may be at increased risk for CHD. Conclusions Data from the present study indicate that the heterogeneity of the association between maternal FA supplementation and CHD is high and suggest that the real relationship between maternal FA supplementation and CHD may need to be further investigated with well-designed clinical studies and biological experiments.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of the association between maternal folic acid supplementation and the risk of congenital heart disease: a systematic review and meta-analysis

Cheng

Lian³

et al. 2022

Nutr J

View full text Add to dashboard Cite

show abstract

“…•Although several studies have shown that folate was not notably associated with asthma or had protective effects against allergic disease, a recent systemic review and meta-analysis suggested that folic acid affected the development of allergic disease, depending on the ingested dose, timing, and intake mode, such as supplements or fortified foods with folic acid (Chen et al, 2021).…”

Section: Folatementioning

confidence: 99%

Effects of Maternal Diet during Pregnancy or Lactation on the Development or Prevention of Allergic Diseases in Offspring

Kim¹

2022

J Korean Soc Matern Child Health

View full text Add to dashboard Cite

The increasing prevalence of allergic diseases in the past decades has been caused by environmental rather than genetic factors. Recent research has focused on the relationship between the mother’s environmental exposure, especially during pregnancy, and allergic outcomes in the offspring. Intervention studies to prevent allergic diseases have also been conducted. Environmental factors, such as diet induce changes in the mother's intestinal flora, and the signals generated have a permanent effect on the fetal immune development through an epigenetic mechanism, which may be involved in disease development. This review outlines whether dietary patterns in mothers are related to allergic diseases, and it summarizes whether supplementation with micronutrients, such as omega-3 unsaturated fatty acids, vitamin D, and folic acid can prevent allergic diseases. Studies have found that a westernized diet is associated with an increase in the prevalence of allergic diseases; however, intervention studies conducted with micronutrients or probiotics do not provide clear results regarding its preventive effect. A mother’s diet during pregnancy or lactation may affect the health of the child. Well-designed intervention studies are warranted to attempt to prevent allergic diseases. Consequently, good dietary patterns based on high-quality evidence are recommended for pregnant and lactating mothers.

show abstract

“…Specifically, methyl donors such as folate take part in one-carbon metabolism, a process that provides methyl groups for DNA or histones methylation among others [93]. Multiple observational studies reported associations between folic acid supplementation during pregnancy and children proneness to develop allergy [92,94], although properly controlled trials are still needed to demonstrate folic acid transgenerational proallergic effect. Moreover, several studies have shown a correlation between methylation changes in immune cells and FA in infants [29,32,37,43,95].…”

Section: Methyl Group Donors Folic Acidmentioning

confidence: 99%

Epigenetics in Food Allergy and Immunomodulation

et al. 2021

View full text Add to dashboard Cite

Food allergy (FA) is an increasing problem worldwide and, over recent years, its prevalence is rising in developed countries. Nowadays, the immunological and cellular processes that occur in the allergic reactions are not fully understood, which hampers the development of in vitro diagnostic tools and further treatment options. Moreover, allergic diseases could be reinforced by environmental exposure and genetic modifications. Gene expression can be controlled by different epigenetic mechanisms like DNA methylation, histone modifications, and microRNAs. In addition, several environmental factors such as dietary components (vitamin D, butyrate, folic acid) are able to regulate this epigenetic mechanism. All these factors produce modifications in immune genes that could alter the development and function of immune cells, and therefore the etiology of the disease. Furthermore, these epigenetic mechanisms have also an influence on immunomodulation, which could explain sustained responsiveness or unresponsiveness during immunotherapy due to epigenetic modifications in key genes that induce tolerance in several FA. Thus, in this review we focus on the different epigenetic mechanisms that occur in FA and on the influence of several dietary components in these gene modifications.

show abstract

Effect of Folic Acid Intake on Infant and Child Allergic Diseases: Systematic Review and Meta-Analysis

Cited by 13 publications

References 30 publications

Evaluation of the association between maternal folic acid supplementation and the risk of congenital heart disease: a systematic review and meta-analysis

Evaluation of the association between maternal folic acid supplementation and the risk of congenital heart disease: a systematic review and meta-analysis

Effects of Maternal Diet during Pregnancy or Lactation on the Development or Prevention of Allergic Diseases in Offspring

Epigenetics in Food Allergy and Immunomodulation

Contact Info

Product

Resources

About