Effect of folic acid supplementation on congenital malformations due to anticonvulsive drugs

Biale, Y; Lewenthal, H

doi:10.1016/0028-2243(84)90119-9

Cited by 65 publications

(22 citation statements)

References 18 publications

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“…Folic acid supplementation is benefi cial in antagonizing the adverse effects of some chemotherapeutic agents (Biale and Lewenthal, 1984;Roncales et al, 2004;Fei et al, 2006;Moat et al, 2006). Interestingly, folic acid plays an important role in experimental hepatitis and elevated homocysteine (Antelava et al, 2007;Clarke, 2008).…”

Section: Introductionmentioning

confidence: 96%

Grape seed extract prevents azathioprine toxicity in rats

El-Ashmawy

Gad

Salama

2010

Phytotherapy Research

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Azathioprine (Aza) is an important drug commonly used in the therapy of autoimmune system disorders. It induces hepatotoxicity and hazard effects that restrict its use. The effects of administration of grape seed extract and folic acid on Aza toxicity by gavage (simultaneously) daily for 4 weeks were studied by determining the changes in some hematological parameters and liver histology. The glutathione level (GSH) and lipid peroxidation content as malondialdehyde (MDA) in the liver tissue were measured. The repeated intake of Aza (25 mg/kg body weight) induced anemia characterized by decreased erythrocyte and leukocyte counts and reticulocyte and hematocrit percentages, while the prothrombin time was significantly increased. Moreover, Aza caused a significant decrease in phagocytic activity and lymphocyte percentage. Aza induced hepatic damage as indicated by pronounced changes in the histological structure, a significant increase in serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP), and MDA content in the liver tissue. Meanwhile, the GSH activity was significantly decreased. Co-treatment with grape seed extract and Aza minimized the previously mentioned hazard effects of Aza and significantly protected the hepatic tissue by ameliorating the antioxidant activity. Folic acid administration, simultaneously, with Aza only improved the anemia. It may be concluded that grape seed extract is a useful herbal remedy, especially for controlling oxidative damages and is considered as a potent protective agent against Aza hepatotoxicity.

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Section: Introductionmentioning

confidence: 96%

Grape seed extract prevents azathioprine toxicity in rats

El-Ashmawy

Gad

Salama

2010

Phytotherapy Research

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“…The offspring of women who took folate antagonists during pregnancy, for example, methotrexate, aminopterin (4-pteroylglutamic acid), and anticonvulsants, appear to be at higher risk for oral clefts (Biale et al, 1975;Hecht et al, 1989;Hernandez-Diaz et al, 2000;Janz, 1975;Milunsky et al, 1989;Thiersch, 1952), and animal studies have demonstrated a teratogenic effect of antifolate factors and folate deficiency (DePaola and Mandella, 1981;Evans et al, 1951;Jordan et al, 1977). Finally, studies in humans have reported a statistically significant protective association between the use of folic acid and/or multivitamins and the risk for oral clefts Itikala et al, 2001;Loffredo et al, 2001;Mitchell et al, 2003;Shaw et al, 1995;van Rooij et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Folic acid–containing supplement consumption during pregnancy and risk for oral clefts: A meta‐analysis

Badovinac

Werler

Williams

et al. 2006

Birth Defects Research

136

103

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BACKGROUND: There is equivocal evidence in the published literature that folic acid supplementation during pregnancy may protect against the common congenital anomalies cleft lip with or without cleft palate (CLP) and cleft palate alone (CP). We undertook this meta-analysis to test the hypothesis that nonsyndromic oral cleft birth prevalences are different for those whose mothers took folic acid-containing supplements and for those whose mothers did not. METHODS: Human studies published in English were identified through MEDLINE, bibliography reviews, and contacting experts in the field. Within strata of prospective and case-control studies, CLP, CP, and all clefts, respectively, were analyzed using either a fixed or random effects model, as appropriate. We assessed for publication bias using Begg and Mazumdar's rank correlation and Egger's regressionbased tests. RESULTS: Five prospective studies were analyzed, yielding combined relative risks of 0.51 (95% CI: 0.32, 0.95) for CLP, 1.19 (95% CI: 0.43, 3.28) for CP, and 0.55 (95% CI: 0.32, 0.95) for all clefts. Twelve casecontrol studies were assessed, which resulted in combined relative risks of 0.77 (95% CI: 0.65, 0.90) for CLP, 0.80 (95% CI: 0.69, 0.93) for CP, and 0.78 (95% CI: 0.71, 0.85) for all clefts. CONCLUSIONS: In aggregate, our results support the hypothesis of a protective effect of folic acid-containing supplement intake during pregnancy on the risk for oral clefts, although this conclusion is tempered by the potential for bias and uncontrolled confounding. Birth Defects Research (Part A) 79:8-15, 2007.

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“…It is thought that this agent has a high likelihood of causing congenital malformation based primarily on experimental studies. 1,5,7,11,13,16,20 However, despite numerous reports, the concentration at which PTH could become harmful has not yet been clarified.…”

Section: Discussionmentioning

confidence: 96%

“…The teratogenic effects of PTH and carbamazepine are still poorly understood. [1][2][3][4][5][6][7][8][9][10][11][12][13] However, a woman with epilepsy who uses anti-epileptic medication during the early stages of pregnancy faces a high risk of teratogenicity.…”

Section: Introductionmentioning

confidence: 99%