Effect of folic acid supplementation on plasma total homocysteine levels and glycemic control in patients with type 2 diabetes: A systematic review and meta-analysis

Sudchada, Patcharaporn; Saokaew, Surasak; Sridetch, Sorattaya; Incampa, Siriwan; Jaiyen, Sopida; Khaithong, Warangkana

doi:10.1016/j.diabres.2012.05.027

Cited by 68 publications

(51 citation statements)

References 50 publications

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“…However, we cannot exclude the possibility that a part of this effect could be associated only with lifestyle changes such as more proper diet and physical activity. We can exclude a putative effect on blood glucose control of folic acid contained in the supplement, as a systematic review and meta-analysis confirm [30]. …”

Section: Resultsmentioning

confidence: 99%

The Effectiveness of Myo-Inositol and D-Chiro Inositol Treatment in Type 2 Diabetes

Pintaudi

Vieste²,

Bonomo

2016

International Journal of Endocrinology

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Inositol has been used as a supplement in treating several pathologies such as PCOS, metabolic syndrome, and gestational diabetes. Both myo-inositol and its isomer d-chiro-inositol showed insulin mimetic effects in conditions of insulin resistance. Type 2 diabetes (T2DM) is a condition typically caused by insulin resistance. There is a lack of evidence of inositol use in T2DM. We evaluated the effectiveness and safety of myo-inositol and d-chiro-inositol treatment in T2DM. This was a pilot study involving a consecutive sample of patients with T2DM with suboptimal glycemic control (HbA1c 7.0–10.0%) already treated with glucose-lowering agents. Patients (23.1% males, mean age of 60.8 ± 11.7 years) took for three months a combination of myo-inositol (550 mg) and d-chiro-inositol (13.8 mg) orally twice a day as add-on supplement to their glucose-lowering drugs. Possible occurrence of side effects was investigated. After three months of treatment fasting blood glucose (192.6 ± 60.2 versus 160.9 ± 36.4; p = 0.02) and HbA1c levels (8.6 ± 0.9 versus 7.7 ± 0.9; p = 0.02) significantly decreased compared to baseline. There was no significant difference in blood pressure, lipid profile, and BMI levels. None of the participants reported side effects. In conclusion, a supplementation with a combination of myo- and d-chiro-inositol is an effective and safe strategy for improving glycemic control in T2DM.

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Section: Resultsmentioning

confidence: 99%

The Effectiveness of Myo-Inositol and D-Chiro Inositol Treatment in Type 2 Diabetes

Pintaudi

Vieste²,

Bonomo

2016

International Journal of Endocrinology

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“…It plays a critical role in the synthesis of SAM, which serves as the methyl group donor in several methylation reactions involving DNA, RNA, and protein [23]. Folic acid supplementation in patient with type 2 DM can reduce Hcy levels and have a trend to associate with better glycemic control compared with placebo [24]. So, we hypothesized that folic acid may reduce tau phosphorylation by regulating methyl metabolism under diabetic conditions.…”

Section: Introductionmentioning

confidence: 99%

Folic Acid Reduces Tau Phosphorylation by Regulating PP2A Methylation in Streptozotocin-Induced Diabetic Mice

Zheng

Zou

et al. 2017

IJMS

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High incidence rate of Alzheimer’s disease (AD) is observed in patients with type 2 diabetes. Aggregated β-amyloid (Aβ) and hyperphosphorylated tau are the hallmarks of AD. Hyperphosphorylated tau has been detected in diabetic animals as well as in diabetic patients. Folates mediate the transfer of one carbon unit, required in various biochemical reactions. The effect of folate on tau phosphorylation in diabetic models still remains unknown. In this study, we investigated the effect and mechanism of folic acid on hyperphosphorylation of tau in streptozotocin (STZ)-induced diabetic mice. Diabetic mice induced by STZ, at the age of 10 weeks, were administered with three levels of folic acid: folic acid-deficient diet, diet with normal folic acid content, and 120 μg/kg folic acid diet for 8 weeks. Levels of serum folate and blood glucose were monitored. Tau phosphorylation, protein phosphatase 2A (PP2A) methylation, and Glycogen synthase kinase 3β (GSK-3β) phosphorylation were detected using Western blot. The S-adenosyl methionine:S-adenosyl homocysteine ratio (SAM:SAH) in brain tissues was also determined. DNA methyltransferase (DNMT) mRNA expression levels were detected using real-time PCR. Folic acid reduced tau hyperphosphorylation at Ser396 in the brain of diabetes mellitus (DM) mice. In addition, PP2A methylation and DNMT1 mRNA expression were significantly increased in DM mice post folic acid treatment. GSK-3β phosphorylation was not regulated by folic acid administration. Folic acid can reduce tau phosphorylation by regulating PP2A methylation in diabetic mice. These results support that folic acid can serve as a multitarget neuronal therapeutic agent for treating diabetes-associated cognitive dysfunction.

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“…Homocysteinemia is partially correctable with folate supplementation. Subsequent improvement in ED was confirmed in researchs examining changes in clinical indices, including albuminuria [23][24][25][26]. Many MPI indices are associated with myocardial perfusion abnormalities and coronary artery disease.…”

Section: Discussionmentioning

confidence: 83%

Folate therapy improves the stress-to-rest mean LV volume ratio in myocardial perfusion imaging in patients with diabetes

et al. 2015

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Effect of folic acid supplementation on plasma total homocysteine levels and glycemic control in patients with type 2 diabetes: A systematic review and meta-analysis

Cited by 68 publications

References 50 publications

The Effectiveness of Myo-Inositol and D-Chiro Inositol Treatment in Type 2 Diabetes

The Effectiveness of Myo-Inositol and D-Chiro Inositol Treatment in Type 2 Diabetes

Folic Acid Reduces Tau Phosphorylation by Regulating PP2A Methylation in Streptozotocin-Induced Diabetic Mice

Folate therapy improves the stress-to-rest mean LV volume ratio in myocardial perfusion imaging in patients with diabetes

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