2014
DOI: 10.1017/s0029665114000780
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Effect of folic acid supplementation during pregnancy on cognitive development of the child at 6 years: preliminary results from the FASSTT Offspring Trial

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Cited by 3 publications
(3 citation statements)
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“…The only RCT to date to look at the specific effect of 0•4 mg/d FA in isolation was conducted at this centre, namely the FASSTT trial (ISRCTN19917787) (13) and provided a unique opportunity to specifically investigate the effect of FA supplementation in the second and third trimesters on subsequent cognitive performance of the child. The results showed that children of mothers supplemented with FA throughout pregnancy performed better in the cognitive domain at age 3 years (72) and the verbal domain at 7 years (73) . These findings are in agreement with the results of animal studies, whereby continuation of maternal FA supplementation increased serum folate concentrations in pregnant rat dams and improved neurodevelopment in their pups, from newborns to adulthood (74) .…”
Section: Maternal Folate and Offspring Cognitive Performancementioning
confidence: 96%
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“…The only RCT to date to look at the specific effect of 0•4 mg/d FA in isolation was conducted at this centre, namely the FASSTT trial (ISRCTN19917787) (13) and provided a unique opportunity to specifically investigate the effect of FA supplementation in the second and third trimesters on subsequent cognitive performance of the child. The results showed that children of mothers supplemented with FA throughout pregnancy performed better in the cognitive domain at age 3 years (72) and the verbal domain at 7 years (73) . These findings are in agreement with the results of animal studies, whereby continuation of maternal FA supplementation increased serum folate concentrations in pregnant rat dams and improved neurodevelopment in their pups, from newborns to adulthood (74) .…”
Section: Maternal Folate and Offspring Cognitive Performancementioning
confidence: 96%
“…The only RCT to date to look at the specific effect of 0·4 mg/d FA in isolation was conducted at this centre, namely the FASSTT trial (ISRCTN19917787) ( 13 ) and provided a unique opportunity to specifically investigate the effect of FA supplementation in the second and third trimesters on subsequent cognitive performance of the child. The results showed that children of mothers supplemented with FA throughout pregnancy performed better in the cognitive domain at age 3 years ( 72 ) and the verbal domain at 7 years ( 73 ) .…”
Section: Maternal Folate and Offspring Cognitive Performancementioning
confidence: 99%
“…Several observational studies have identified a potential role of maternal folate status during pregnancy on the cognitive performance of offspring (6,7,8). We previously investigated the children of mothers who had participated in a randomized trial in pregnancy of Folic Acid Supplementation in the Second and Third Trimesters (FASSTT) (9) and, in a preliminary publication, found beneficial effects of FA on cognition in children at age 3 and 6 years (10). Although, the precise biological mechanism explaining the effect of FA during pregnancy on neurodevelopment of the child is unknown, it must involve the essential role of folate in onecarbon metabolism, whereby one-carbon units are transferred and utilized in critical pathways involving amino acid metabolism, biosynthesis of purines and pyrimidines and the methylation of biological substrates including DNA.…”
Section: Introductionmentioning
confidence: 99%